Musallam KM, Tamim HM, Richards T, et al. Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. Lancet 2011; 378: 1396–407. https://doi.org/10.1016/s0140-6736(11)61381-0

Article  PubMed  Google Scholar 

Hung M, Besser M, Sharples LD, Nair SK, Klein AA. The prevalence and association with transfusion, intensive care unit stay and mortality of pre-operative anaemia in a cohort of cardiac surgery patients. Anaesthesia 2011; 66: 812–8. https://doi.org/10.1111/j.1365-2044.2011.06819.x

Article  CAS  PubMed  Google Scholar 

Gómez-Ramirez S, Jericó C, Muñoz M. Perioperative anemia: prevalence, consequences and pathophysiology. Transfus Apher Sci 2019; 58: 369–74. https://doi.org/10.1016/j.transci.2019.06.011

Article  PubMed  Google Scholar 

Kulier A, Levin J, Moser R, et al. Impact of preoperative anemia on outcome in patients undergoing coronary artery bypass graft surgery. Circulation 2007; 116: 471–9. https://doi.org/10.1161/circulationaha.106.653501

Article  PubMed  Google Scholar 

Padmanabhan H, Brookes MJ, Nevill AM, Luckraz H. Association between anemia and blood transfusion with long-term mortality after cardiac surgery. Ann Thorac Surg 2019; 108: 687–92. https://doi.org/10.1016/j.athoracsur.2019.04.044

Article  PubMed  Google Scholar 

Dunkelgrun M, Hoeks SE, Welten GM, et al. Anemia as an independent predictor of perioperative and long-term cardiovascular outcome in patients scheduled for elective vascular surgery. Am J Cardiol 2008; 101: 1196–200. https://doi.org/10.1016/j.amjcard.2007.11.072

Article  PubMed  Google Scholar 

Ripoll JG, Smith MM, Hanson AC, et al. Sex-specific associations between preoperative anemia and postoperative clinical outcomes in patients undergoing cardiac surgery. Anesth Analg 2021; 132: 1101–11. https://doi.org/10.1213/ane.0000000000005392

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gupta PK, Sundaram A, MacTaggart JN, et al. Preoperative anemia is an independent predictor of postoperative mortality and adverse cardiac events in elderly patients undergoing elective vascular operations. Ann Surg 2013; 258: 1096–102. https://doi.org/10.1097/sla.0b013e318288e957

Article  PubMed  Google Scholar 

Padmanabhan H, Aktuerk D, Brookes MJ, et al. Anemia in cardiac surgery: next target for mortality and morbidity improvement? Asian Cardiovasc Thorac Ann 2016; 24: 12–7. https://doi.org/10.1177/0218492315618032

Article  PubMed  Google Scholar 

Fowler AJ, Ahmad T, Phull MK, Allard S, Gillies MA, Pearse RM. Meta-analysis of the association between preoperative anaemia and mortality after surgery. Br J Surg 2015; 102: 1314–24. https://doi.org/10.1002/bjs.9861

Article  CAS  PubMed  Google Scholar 

Baron DM, Hochrieser H, Posch M, et al. Preoperative anaemia is associated with poor clinical outcome in non-cardiac surgery patients. Br J Anaesth 2014; 113: 416–23. https://doi.org/10.1093/bja/aeu098

Article  CAS  PubMed  Google Scholar 

Greenky M, Gandhi K, Pulido L, Restrepo C, Parvizi J. Preoperative Anemia in total joint arthroplasty: is it associated with periprosthetic joint infection? Clin Orthop Relat Res 2012; 470: 2695–701. https://doi.org/10.1007/s11999-012-2435-z

Article  PubMed  PubMed Central  Google Scholar 

De Santo L, Romano G, Della Corte A, et al. Preoperative anemia in patients undergoing coronary artery bypass grafting predicts acute kidney injury. J Thorac Cardiovasc Surg 2009; 138: 965–70. https://doi.org/10.1016/j.jtcvs.2009.05.013

Article  PubMed  Google Scholar 

Saager L, Turan A, Reynolds LF, Dalton JE, Mascha EJ, Kurz A. The association between preoperative anemia and 30-day mortality and morbidity in noncardiac surgical patients. Anesth Analg 2013; 117: 909–15. https://doi.org/10.1213/ane.0b013e31828b347d

Article  PubMed  Google Scholar 

Sakr Y, Lobo S, Knuepfer S, et al. Anemia and blood transfusion in a surgical intensive care unit. Crit Care 2010; 14: R92. https://doi.org/10.1186/cc9026

Article  PubMed  PubMed Central  Google Scholar 

Joshi SS, George A, Manasa D, Savita HM, Krishna PT, Jagadeesh AM. Propensity-matched analysis of association between preoperative anemia and in-hospital mortality in cardiac surgical patients undergoing valvular heart surgeries. Ann Card Anaesth 2015; 18: 373–9. https://doi.org/10.4103/0971-9784.159808

Article  PubMed  PubMed Central  Google Scholar 

Ranucci M, Di Dedda U, Castelvecchio S, Menicanti L, Frigiola A, Pelissero G. Impact of preoperative anemia on outcome in adult cardiac surgery: a propensity-matched analysis. Ann Thorac Surg 2012; 94: 1134–41. https://doi.org/10.1016/j.athoracsur.2012.04.042

Article  PubMed  Google Scholar 

Hazen YJ, Noordzij PG, Gerritse BM, et al. Preoperative anaemia and outcome after elective cardiac surgery: a Dutch national registry analysis. Br J Anaesth 2022; 128: 636–43. https://doi.org/10.1016/j.bja.2021.12.016

Article  PubMed  Google Scholar 

Dunne JR, Malone D, Tracy JK, Gannon C, Napolitano LM. Perioperative anemia: an independent risk factor for infection, mortality, and resource utilization in surgery. J Surg Res 2002; 102: 237–44. https://doi.org/10.1006/jsre.2001.6330

Article  PubMed  Google Scholar 

Carrascal Y, Maroto L, Rey J, et al. Impact of preoperative anemia on cardiac surgery in octogenarians. Interact Cardiovasc Thorac Surg 2010; 10: 249–55. https://doi.org/10.1510/icvts.2009.220160

Article  PubMed  Google Scholar 

Miceli A, Romeo F, Glauber M, de Siena PM, Caputo M, Angelini GD. Preoperative anemia increases mortality and postoperative morbidity after cardiac surgery. J Cardiothorac Surg 2014; 9: 137. https://doi.org/10.1186/1749-8090-9-137

Article  PubMed  PubMed Central  Google Scholar 

Jabagi H, Boodhwani M, Tran DT, Sun L, Wells G, Rubens FD. The effect of preoperative anemia on patients undergoing cardiac surgery: a propensity-matched analysis. Semin Thorac Cardiovasc Surg 2019; 31: 157–63. https://doi.org/10.1053/j.semtcvs.2018.09.015

Article  PubMed  Google Scholar 

Padmanabhan H, Siau K, Curtis J, et al. Preoperative anemia and outcomes in cardiovascular surgery: systematic review and meta-analysis. Ann Thorac Surg 2019; 108: 1840–8. https://doi.org/10.1016/j.athoracsur.2019.04.108

Article  PubMed  Google Scholar 

Hogervorst EK, Rosseel PM, van de Watering LM, et al. Intraoperative anemia and single red blood cell transfusion during cardiac surgery: an assessment of postoperative outcome including patients refusing blood transfusion. J Cardiothorac Vasc Anesth 2016; 30: 363–72. https://doi.org/10.1053/j.jvca.2015.10.021

Article  PubMed  Google Scholar 

Baethge C, Goldbeck-Wood S, Mertens S. SANRA—a scale for the quality assessment of narrative review articles. Res Integr Peer Rev 2019; 4: 5. https://doi.org/10.1186/s41073-019-0064-8

Article  PubMed  PubMed Central  Google Scholar 

Cui R, Li F, Shao J, et al. Postoperative anemia is a risk factor for acute kidney injury after open aorta and vena cava surgeries. PLoS One 2020; 15: e0240243. https://doi.org/10.1371/journal.pone.0240243

Article  CAS  PubMed  PubMed Central  Google Scholar 

Westenbrink BD, Kleijn L, de Boer RA, et al. Sustained postoperative anaemia is associated with an impaired outcome after coronary artery bypass graft surgery: insights from the IMAGINE trial. Heart 2011; 97: 1590–6. https://doi.org/10.1136/heartjnl-2011-300118

Article  CAS  PubMed  Google Scholar 

Vlot EA, Verwijmeren L, van de Garde EM, Kloppenburg GT, van Dongen EP, Noordzij PG. Intra-operative red blood cell transfusion and mortality after cardiac surgery. BMC Anesthesiol 2019; 19: 65. https://doi.org/10.1186/s12871-019-0738-2

Article  PubMed  PubMed Central  Google Scholar 

Muñoz M, Acheson AG, Bisbe E, et al. An international consensus statement on the management of postoperative anaemia after major surgical procedures. Anaesthesia 2018; 73: 1418–31. https://doi.org/10.1111/anae.14358

Article  PubMed  PubMed Central  Google Scholar 

Muñoz M, García-Erce JA, Remacha ÁF. Disorders of iron metabolism. Part II: iron deficiency and iron overload. J Clin Pathol 2011; 64: 287–96. https://doi.org/10.1136/jcp.2010.086991

Article  CAS  PubMed  Google Scholar 

van Iperen CE, Gaillard CA, Kraaijenhagen RJ, Braam BG, Marx JJ, van de Wiel A. Response of erythropoiesis and iron metabolism to recombinant human erythropoietin in intensive care unit patients. Crit Care Med 2000; 28: 2773–8. https://doi.org/10.1097/00003246-200008000-00015

Article  PubMed  Google Scholar 

van Iperen CE, Kraaijenhagen RJ, Biesma DH, Beguin Y, Marx JJ, van de Wiel A. Iron metabolism and erythropoiesis after surgery. Br J Surg 2003; 85: 41–5. https://doi.org/10.1046/j.1365-2168.1998.00571.x

Article  Google Scholar 

World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Available from URL: WHO_NMH_NHD_MNM_11.1_eng.pdf (accessed August 2023).

Smoor RM, Rettig TC, Vernooij LM, et al. Postoperative anaemia and disability-free survival in older cardiac surgery patients. Br J Anaesth 2022; 129: e27–9. https://doi.org/10.1016/j.bja.2022.04.017

Article  PubMed  Google Scholar 

Oprea AD, Del Rio JM, Cooter M, et al. Pre- and postoperative anemia, acute kidney injury, and mortality after coronary artery bypass grafting surgery: a retrospective observational study. Can J Anesth 2018; 65: 46–59. https://doi.org/10.1007/s12630-017-0991-0

Article  PubMed