Icen, M. et al. Trends in incidence of adult-onset psoriasis over three decades: a population-based study. J. Am. Acad. Dermatol. 60, 394–401 (2009).

Article  PubMed  PubMed Central  Google Scholar 

Damiani, G. et al. The global, regional, and national burden of psoriasis: results and insights from the global burden of disease 2019 study. Front. Med. 8, 743180 (2021).

Article  Google Scholar 

Parisi, R. et al. National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study. BMJ 369, m1590 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Meyer, N. et al. Psoriasis: an epidemiological evaluation of disease burden in 590 patients. J. Eur. Acad. Dermatol. Venereol. 24, 1075–1082 (2010).

Article  CAS  PubMed  Google Scholar 

Villacorta, R. et al. A multinational assessment of work-related productivity loss and indirect costs from a survey of patients with psoriasis. Br. J. Dermatol. 183, 548–558 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao, F. et al. Global burden and cross-country inequalities in autoimmune diseases from 1990 to 2019. Autoimmun. Rev. 22, 103326 (2023).

Article  PubMed  Google Scholar 

Wang, H. M., Xu, J. M. & Jin, H. Z. Characteristics and burdens of disease in patients from beijing with generalized pustular psoriasis and palmoplantar pustulosis: multicenter retrospective cohort study using a regional database. Am. J. Clin. Dermatol. https://doi.org/10.1007/s40257-023-00807-2 (2023).

Pilon, D. et al. The economic burden of psoriasis with high comorbidity among privately insured patients in the United States. J. Med Econ. 22, 196–203 (2019).

Article  PubMed  Google Scholar 

Singh, S., Taylor, C., Kornmehl, H. & Armstrong, A. W. Psoriasis and suicidality: a systematic review and meta-analysis. J. Am. Acad. Dermatol. 77, 425–440.e422 (2017).

Article  PubMed  Google Scholar 

Matterne, U., Baumeister, S. E. & Apfelbacher, C. J. Suicidality and risk of suicidality in psoriasis: a critical appraisal of two systematic reviews and meta-analyses. Br. J. Dermatol. 181, 717–721 (2019).

Article  CAS  PubMed  Google Scholar 

Armstrong, A. W. & Read, C. Pathophysiology, clinical presentation, and treatment of psoriasis: a review. JAMA 323, 1945–1960 (2020).

Article  CAS  PubMed  Google Scholar 

Griffiths, C. E. M., Armstrong, A. W., Gudjonsson, J. E. & Barker, J. Psoriasis. Lancet 397, 1301–1315 (2021).

Article  CAS  PubMed  Google Scholar 

Patrick, M. T. et al. Shared genetic risk factors and causal association between psoriasis and coronary artery disease. Nat. Commun. 13, 6565 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Veale, D. J. & Fearon, U. The pathogenesis of psoriatic arthritis. Lancet 391, 2273–2284 (2018).

Article  CAS  PubMed  Google Scholar 

Yan, D., Afifi, L., Jeon, C., Cordoro, K. M. & Liao, W. A cross-sectional study of psoriasis triggers among different ethno-racial groups. J. Am. Acad. Dermatol. 77, 756–758.e751 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Twelves, S. et al. Clinical and genetic differences between pustular psoriasis subtypes. J. Allergy Clin. Immunol. 143, 1021–1026 (2019).

Article  PubMed  PubMed Central  Google Scholar 

FitzGerald, O. et al. Psoriatic arthritis. Nat. Rev. Dis. Prim. 7, 59 (2021).

Article  PubMed  Google Scholar 

Chalmers, R., O’Sullivan, T., Owen, C. M. & Griffiths, C. E. WITHDRAWN: interventions for guttate psoriasis. Cochrane Database Syst. Rev. 4, Cd001213 (2019).

PubMed  Google Scholar 

Carrasquillo, O. Y. et al. Treatment of erythrodermic psoriasis with biologics: a systematic review. J. Am. Acad. Dermatol. 83, 151–158 (2020).

Article  CAS  PubMed  Google Scholar 

Elmets, C. A. et al. Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities. J. Am. Acad. Dermatol. 80, 1073–1113 (2019).

Article  PubMed  Google Scholar 

Kaushik, S. B. & Lebwohl, M. G. Psoriasis: which therapy for which patient: psoriasis comorbidities and preferred systemic agents. J. Am. Acad. Dermatol. 80, 27–40 (2019).

Article  PubMed  Google Scholar 

Korman, N. J. Management of psoriasis as a systemic disease: what is the evidence? Br. J. Dermatol. 182, 840–848 (2020).

Article  CAS  PubMed  Google Scholar 

Kim, W. B., Jerome, D. & Yeung, J. Diagnosis and management of psoriasis. Can. Fam. Phys. 63, 278–285 (2017).

Google Scholar 

Boehncke, W. H. & Schön, M. P. Psoriasis. Lancet 386, 983–994 (2015).

Article  CAS  PubMed  Google Scholar 

Bronckers, I. M., Paller, A. S., van Geel, M. J., van de Kerkhof, P. C. & Seyger, M. M. Psoriasis in children and adolescents: diagnosis, management and comorbidities. Paediatr. Drugs 17, 373–384 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

van de Kerkhof, P. C. From empirical to pathogenesis-based treatments for psoriasis. J. Invest. Dermatol. 142, 1778–1785 (2022).

Article  PubMed  Google Scholar 

Rendon, A. & Schäkel, K. Psoriasis pathogenesis and treatment. Int J. Mol. Sci. 20, 1475 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raychaudhuri, S. P., Wilken, R., Sukhov, A. C., Raychaudhuri, S. K. & Maverakis, E. Management of psoriatic arthritis: early diagnosis, monitoring of disease severity and cutting edge therapies. J. Autoimmun. 76, 21–37 (2017).

Article  PubMed  Google Scholar 

Coates, L. C. et al. Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021. Nat. Rev. Rheumatol. 18, 465–479 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Ghoreschi, K., Balato, A., Enerbäck, C. & Sabat, R. Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis. Lancet 397, 754–766 (2021).

Article  CAS  PubMed  Google Scholar 

Kumar, R., Theiss, A. L. & Venuprasad, K. RORγt protein modifications and IL-17-mediated inflammation. Trends Immunol. 42, 1037–1050 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conrad, C. & Gilliet, M. Psoriasis: from pathogenesis to targeted therapies. Clin. Rev. Allergy Immunol. 54, 102–113 (2018).

Article  CAS  PubMed  Google Scholar 

Deng, Y., Chang, C. & Lu, Q. The inflammatory response in psoriasis: a comprehensive review. Clin. Rev. Allergy Immunol. 50, 377–389 (2016).

Article  CAS  PubMed  Google Scholar 

Vičić, M., Kaštelan, M., Brajac, I., Sotošek, V. & Massari, L. P. Current concepts of psoriasis immunopathogenesis. Int J. Mol. Sci. 22, 11574 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Chandra, A., Ray, A., Senapati, S. & Chatterjee, R. Genetic and epigenetic basis of psoriasis pathogenesis. Mol. Immunol. 64, 313–323 (2015).

Article  CAS  PubMed  Google Scholar 

Trowbridge, R. M. & Pittelkow, M. R. Epigenetics in the pathogenesis and pathophysiology of psoriasis vulgaris. J. Drugs Dermatol 13, 111–118 (2014).

CAS  PubMed  Google Scholar 

Blunder, S., Pavel, P., Minzaghi, D. & Dubrac, S. PPARdelta in affected atopic dermatitis and psoriasis: a possible role in metabolic reprograming. Int J. Mol. Sci. 22, 7354 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lian, N., Shi, L. Q., Hao, Z. M. & Chen, M. Research progress and perspective in metabolism and metabolomics of psoriasis. Chin. Med. J. 133, 2976–2986 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang, B., Zhang, H., Wu, Y. & Shen, Y. Single-cell immune ecosystem and metabolism reprogramming imprinted by psoriasis niche. Ann. Transl. Med. 10, 837 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nair, R. P. et al. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat. Genet. 41, 199–204 (2009).

Article  CAS