Ungaro, R., S. Mehandru, P.B. Allen, et al. 2017. Ulcerative colitis. Lancet 389 (10080): 1756–1770.

Article  PubMed  Google Scholar 

Conrad, K., D. Roggenbuck, and M.W. Laass. 2014. Diagnosis and classification of ulcerative colitis. Autoimmunity Reviews 13 (4–5): 463–466.

Article  PubMed  CAS  Google Scholar 

Ng, S.C., H.Y. Shi, N. Hamidi, et al. 2017. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies. Lancet 390 (10114): 2769–2778.

Article  PubMed  Google Scholar 

Hauso, Ø., T.C. Martinsen, and H. Waldum. 2015. 5-Aminosalicylic acid, a specific drug for ulcerative colitis. Scandinavian Journal of Gastroenterology 50 (8): 933–941.

Article  PubMed  CAS  Google Scholar 

Bonovas, S., K. Pantavou, D. Evripidou, et al. 2018. Safety of biological therapies in ulcerative colitis: An umbrella review of meta-analyses. Best Practice & Research Clinical Gastroenterology 32–33: 43–47.

Article  Google Scholar 

Umehara, Y., M. Kudo, R. Nakaoka, et al. 2006. Serum proinflammatory cytokines and adhesion molecules in ulcerative colitis. Hepato-Gastroenterology 53 (72): 879–882.

PubMed  CAS  Google Scholar 

Neurath, M.F., S. Finotto, I. Fuss, et al. 2001. Regulation of T-cell apoptosis in inflammatory bowel disease: To die or not to die, that is the mucosal question. Trends in Immunology 22 (1): 21–26.

Article  PubMed  CAS  Google Scholar 

Kusugami, K., A. Fukatsu, M. Tanimoto, et al. 1995. Elevation of interleukin-6 in inflammatory bowel disease is macrophage- and epithelial cell-dependent. Digestive Diseases and Sciences 40 (5): 949–959.

Article  PubMed  CAS  Google Scholar 

Olsen, T., R. Goll, G. Cui, et al. 2009. TNF-alpha gene expression in colorectal mucosa as a predictor of remission after induction therapy with infliximab in ulcerative colitis. Cytokine 46 (2): 222–227.

Article  PubMed  CAS  Google Scholar 

Page, M.J., J. Bester, and E. Pretorius. 2018. The inflammatory effects of TNF-α and complement component 3 on coagulation. Science and Reports 8 (1): 1812.

Article  Google Scholar 

Farina, G., R. Lemaire, P. Pancari, et al. 2009. Cartilage oligomeric matrix protein expression in systemic sclerosis reveals heterogeneity of dermal fibroblast responses to transforming growth factor beta. Annals of the Rheumatic Diseases 68 (3): 435–441.

Article  PubMed  CAS  Google Scholar 

Schulz, J.N., J. Nüchel, A. Niehoff, et al. 2016. COMP-assisted collagen secretion–a novel intracellular function required for fibrosis. Journal of Cell Science 129 (4): 706–716.

PubMed  CAS  Google Scholar 

Szondy, Z., and A. Pallai. 2017. Transmembrane TNF-alpha reverse signaling leading to TGF-beta production is selectively activated by TNF targeting molecules: Therapeutic implications. Pharmacological Research 115: 124–132.

Article  PubMed  CAS  Google Scholar 

Xu, H., Q. Li, Y. Zhao, et al. 2016. Intestinal NHE8 is highly expressed in goblet cells and its expression is subject to TNF-α regulation. American Journal of Physiology. Gastrointestinal and Liver Physiology 310 (2): G64-69.

Article  PubMed  Google Scholar 

Musch, M.W., L.L. Clarke, D. Mamah, et al. 2002. T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase. The Journal of Clinical Investigation 110 (11): 1739–1747.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li, X., Z. Wu, X. Fu, et al. 2013. Long Noncoding RNAs: Insights from Biological Features and Functions to Diseases. Medicinal Research Reviews 33 (3): 517–553.

Article  PubMed  Google Scholar 

Ma, Z., Y.Y. Wang, H.W. Xin, et al. 2019. The expanding roles of long non-coding RNAs in the regulation of cancer stem cells. International Journal of Biochemistry & Cell Biology 108: 17–20.

Article  CAS  Google Scholar 

Ashrafizadeh, M., A. Zarrabi, E. Mostafavi, et al. 2022. Non-coding RNA-based regulation of inflammation. Seminars in Immunology 59: 101606.

Article  PubMed  CAS  Google Scholar 

Chew, C.L., S.A. Conos, B. Unal, et al. 2018. Noncoding RNAs: Master Regulators of Inflammatory Signaling. Trends in Molecular Medicine 24 (1): 66–84.

Article  PubMed  CAS  Google Scholar 

Chen, S.W., P.Y. Wang, Y.C. Liu, et al. 2016. Effect of Long Noncoding RNA H19 Overexpression on Intestinal Barrier Function and Its Potential Role in the Pathogenesis of Ulcerative Colitis. Inflammatory Bowel Diseases 22 (11): 2582–2592.

Article  PubMed  Google Scholar 

Padua, D., S. Mahurkar-Joshi, I.K. Law, et al. 2016. A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation. American Journal of Physiology. Gastrointestinal and Liver Physiology 311 (3): G446-457.

Article  PubMed  PubMed Central  Google Scholar 

Akıncılar, S.C., L. Wu, Q.F. Ng, et al. 2021. NAIL: An evolutionarily conserved lncRNA essential for licensing coordinated activation of p38 and NFκB in colitis. Gut 70 (10): 1857–1871.

Article  PubMed  Google Scholar 

Congrains, A., K. Kamide, M. Ohishi, et al. 2013. ANRIL: Molecular mechanisms and implications in human health. International Journal of Molecular Sciences 14 (1): 1278–1292.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang, D., G. Sun, H. Zhang, et al. 2017. Long non-coding RNA ANRIL indicates a poor prognosis of cervical cancer and promotes carcinogenesis via PI3K/Akt pathways. Biomedicine & Pharmacotherapy 85: 511–516.

Article  CAS  Google Scholar 

Royds, J.A., A.P. Pilbrow, A. Ahn, et al. 2015. The rs11515 Polymorphism Is More Frequent and Associated With Aggressive Breast Tumors with Increased ANRIL and Decreased p16 (INK4a) Expression. Frontiers in Oncology 5: 306.

PubMed  Google Scholar 

Mirza, A.H., C.H. Berthelsen, S.E. Seemann, et al. 2015. Transcriptomic landscape of lncRNAs in inflammatory bowel disease. Genome Med 7 (1): 39.

Article  PubMed  PubMed Central  Google Scholar 

Olsen, J., T.A. Gerds, J.B. Seidelin, et al. 2009. Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling of genome-wide gene expression data. Inflammatory Bowel Diseases 15 (7): 1032–1038.

Article  PubMed  Google Scholar 

Funakoshi, T., K. Yamashita, N. Ichikawa, et al. 2012. A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice. Journal of Crohn’s & Colitis 6 (2): 215–225.

Article  Google Scholar 

Dieleman, L.A., M.J. Palmen, H. Akol, et al. 1998. Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clinical and Experimental Immunology 114 (3): 385–391.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lu, J.W., A. Rouzigu, L.H. Teng, et al. 2021. The Construction and Comprehensive Analysis of Inflammation-Related ceRNA Networks and Tissue-Infiltrating Immune Cells in Ulcerative Progression. BioMed Research International 2021: 6633442.

Article  PubMed  PubMed Central  Google Scholar 

Beyer, M., Y. Thabet, R.U. Müller, et al. 2011. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nature Immunology 12 (9): 898–907.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kondo, M., Y. Tanaka, T. Kuwabara, et al. 2016. SATB1 Plays a Critical Role in Establishment of Immune Tolerance. The Journal of Immunology 196 (2): 563–572.

Article  PubMed  CAS  Google Scholar 

Yarani, R., A.H. Mirza, S. Kaur, et al. 2018. The emerging role of lncRNAs in inflammatory bowel disease. Experimental & Molecular Medicine 50 (12): 1–14.

Article  Google Scholar 

Chapman, C.G., and J. Pekow. 2015. The emerging role of miRNAs in inflammatory bowel disease: A review. Therap Adv Gastroenterol 8 (1): 4–22.

Article  PubMed  PubMed Central  Google Scholar 

Fernandes, J.C.R., S.M., Acuña, J.I. Aoki, et al. (2019). Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease. Noncoding RNA, 5(1).

Makeyev, E.V., and T. Maniatis. 2008. Multilevel regulation of gene expression by microRNAs. Science 319 (5871): 1789–1790.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Godnic, I., M. Zorc, D. Jevsinek Skok, et al. 2013. Genome-wide and species-wide in silico screening for intragenic MicroRNAs in human, mouse and chicken. PLoS ONE 8 (6): e65165.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zacharopoulou, E., M. Gazouli, M. Tzouvala, et al. 2017. The contribution of long non-coding RNAs in Inflammatory Bowel Diseases. Digestive and Liver Disease 49 (10): 1067–1072.

Article  PubMed  CAS  Google Scholar 

Xia, H., S. Li, Y. He, et al. 2022. Long non-coding RNA ANRIL serves as a potential marker of disease risk, inflammation, and disease activity of pediatric inflammatory bowel disease. Clinics and Research in Hepatology and Gastroenterology 46 (4): 101895.

Article  PubMed  CAS