Arvanil induces ferroptosis of hepatocellular carcinoma by binding to MICU1

Forner A, Reig M, Bruix J. Hepatocellular carcinoma. Lancet. 2018;391:1301–14.

Article  PubMed  Google Scholar 

Anwanwan D, Singh K, Singh S, Saikam V, Singh R. Challenges in liver cancer and possible treatment approaches. Biochim Biophys Acta Rev Cancer. 2020;1873:188314.

Article  CAS  PubMed  Google Scholar 

Llovet M, De Baere T, Kulik L, Haber K, Greten F, Meyer T, et al. Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 2021;18:293–313.

Article  CAS  PubMed  Google Scholar 

Llovet M, Montal R, Sia D, Finn S. Molecular therapies and precision medicine for hepatocellular carcinoma. Nat Rev Clin Oncol. 2018;15:599–616.

Article  PubMed  Google Scholar 

Kastan B, Bartek J. Cell-cycle checkpoints and cancer. Nature. 2004;432:316–23.

Article  CAS  PubMed  Google Scholar 

Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–74.

Article  CAS  PubMed  Google Scholar 

Talmadge E, Fidler J. AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res. 2010;70:5649–69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clark R, Lee H. Anticancer properties of capsaicin against human cancer. Anticancer Res. 2016;36:837–43.

CAS  PubMed  Google Scholar 

Chen C, Ko C, Yen C, Chen Y, Lin C, Ma F, et al. Capsaicin enhances erlotinib-induced cytotoxicity via AKT inactivation and excision repair cross-complementary 1 (ERCC1) down-regulation in human lung cancer cells. Toxicol Res. 2019;8:459–70.

Article  CAS  Google Scholar 

Han H, Park K, Nakamura H, Ban S. Capsaicin inhibits HIF-1alpha accumulation through suppression of mitochondrial respiration in lung cancer cells. Biomed Pharmacother. 2022;146:112500.

Article  CAS  PubMed  Google Scholar 

Hurley D, Akers T, Friedman R, Nolan A, Brown C, Dasgupta P. Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers. Cell Adh Migr. 2017;11:80–97.

Article  CAS  PubMed  Google Scholar 

Dixon J, Lemberg M, Lamprecht R, Skouta R, Zaitsev M, Gleason E, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li P, Jiang M, Li K, Li H, Zhou Y, Xiao X, et al. Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity. Nat Immunol. 2021;22:1107–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vasan K, Werner M, Chandel S. Mitochondrial metabolism as a target for cancer therapy. Cell Metabol. 2020;32:341–52.

Article  CAS  Google Scholar 

Zhao L, Tang M, Bode M, Liao W, Cao Y. ANTs and cancer: emerging pathogenesis, mechanisms, and perspectives. Biochim Biophys Acta. 2021;1875:188485.

CAS  Google Scholar 

Bonora M, Giorgi C, Pinton P. Molecular mechanisms and consequences of mitochondrial permeability transition. Nat Rev. Mol Cell Biol. 2022;23:266–85.

Article  CAS  PubMed  Google Scholar 

Zhao L, Deng X, Li Y, Hu J, Xie L, Shi F, et al. Conformational change of adenine nucleotide translocase-1 mediates cisplatin resistance induced by EBV-LMP1. EMBO Mol Med. 2021;13:e14072.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morciano G, Naumova N, Koprowski P, Valente S, Sardão VA, Potes Y, et al. The mitochondrial permeability transition pore: an evolving concept critical for cell life and death. Biol Rev Camb Philos Soc. 2021;96:2489–521.

Article  CAS  PubMed  Google Scholar 

Garbincius F, Elrod W. Mitochondrial calcium exchange in physiology and disease. Physiol Rev. 2022;102:893–992.

Article  CAS  PubMed  Google Scholar 

Gao Y, Hou R, Fei Q, Fang L, Han Y, Cai R, et al. The Three-Herb Formula Shuang-Huang-Lian stabilizes mast cells through activation of mitochondrial calcium uniporter. Sci Rep. 2017;7:38736.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bermont F, Hermant A, Benninga R, Chabert C, Jacot G, Santo-Domingo J, et al. Targeting mitochondrial calcium uptake with the natural flavonol kaempferol, to promote metabolism/secretion coupling in pancreatic β-cells. Nutrients. 2020;12:538.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee S, Kang S, Lee S, Nicolova S, Kim A. Involvement of NADPH oxidase-mediated generation of reactive oxygen species in the apototic cell death by capsaicin in HepG2 human hepatoma cells. Free Radic Res. 2004;38:405–12.

Article  CAS  PubMed  Google Scholar 

Vendrely V, Peuchant E, Buscail E, Moranvillier I, Rousseau B, Bedel A, et al. Resveratrol and capsaicin used together as food complements reduce tumor growth and rescue full efficiency of low dose gemcitabine in a pancreatic cancer model. Cancer Lett. 2017;390:91–102.

Article  CAS  PubMed  Google Scholar 

Vendrely V, Amintas S, Noel C, Moranvillier I, Lamrissi I, Rousseau B, et al. Combination treatment of resveratrol and capsaicin radiosensitizes pancreatic tumor cells by unbalancing DNA repair response to radiotherapy towards cell death. Cancer Lett. 2019;451:1–10.

Article  CAS  PubMed  Google Scholar 

Thoennissen H, O’Kelly J, Lu D, Iwanski B, La T, Abbassi S, et al. Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene. 2010;29:285–96.

Article  CAS  PubMed  Google Scholar 

Lv L, Zhuang X, Zhang W, Tian N, Dang Z, Wu Y. Capsaicin-loaded folic acid-conjugated lipid nanoparticles for enhanced therapeutic efficacy in ovarian cancers. Biomed Pharmacother. 2017;91:999–1005.

Article  CAS  PubMed  Google Scholar 

Liu Y, Wei G, Li S. Capsaicin induces ferroptosis of NSCLC by regulating SLC7A11/GPX4 signaling in vitro. Sci Rep. 2022;12:11996.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang P, Chen C, Wu C, Chen T, Tang Y, Ho T, et al. Capsaicin-induced apoptosis in human hepatoma HepG2 cells. Anticancer Res. 2009;29:165–74.

CAS  PubMed  Google Scholar 

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