SLAMF7 Promotes Foam Cell Formation of Macrophage by Suppressing NR4A1 Expression During Carotid Atherosclerosis

Bonati L. H., O. Jansen, G. J. de Borst, M. M. Brown. 2022. Management of atherosclerotic extracranial carotid artery stenosis. Lancet Neurology 21 (3):273–283. https://doi.org/10.1016/S1474-4422(21)00359-8.

Tzoulaki I., R. Castagné, C. L. Boulangé, I. Karaman, E. Chekmeneva, E. Evangelou, T. M. D. Ebbels, M. R. Kaluarachchi, M. Chadeau-Hyam, D. Mosen, A. Dehghan, A. Moayyeri, D. L. S. Ferreira, X. Guo, J. I. Rotter, K. D. Taylor, M. Kavousi, P. S. de Vries, B. Lehne, M. Loh, A. Hofman, J. K. Nicholson, J. Chambers, C. Gieger, E. Holmes, R. Tracy, J. Kooner, P. Greenland, O. H. Franco, D. Herrington, J. C. Lindon, P. Elliott. 2019. Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease. European Heart Journal 40 (34):2883–2896. https://doi.org/10.1093/eurheartj/ehz235.

Liu Z., H. Zhu, X. Dai, C. Wang, Y. Ding, P. Song, M. H. Zou. 2017. Macrophage liver kinase B1 inhibits foam cell formation and atherosclerosis. Circulation Research 121 (9):1047–1057. https://doi.org/10.1161/CIRCRESAHA.117.311546.

Libby P., J. E. Buring, L. Badimon, G. K. Hansson, J. Deanfield, M. S. Bittencourt, L. Tokgozoglu, E. F. Lewis. 2019. Atherosclerosis. Nature Reviews Disease Primers 5 (1):56. https://doi.org/10.1038/s41572-019-0106-z.

Summerhill V. I., A. V. Grechko, S. F. Yet, I. A. Sobenin, A. N. Orekhov. 2019. The atherogenic role of circulating modified lipids in atherosclerosis. International Journal of Molecular Sciences 20 (14). https://doi.org/10.3390/ijms20143561.

Hartley A., D. Haskard, R. Khamis. 2019. Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis - novel insights and future directions in diagnosis and therapy<sup/>. Trends in Cardiovascular Medicine 29 (1):22–26. https://doi.org/10.1016/j.tcm.2018.05.010.

Tabas I., K. E. Bornfeldt. 2020. Intracellular and intercellular aspects of macrophage immunometabolism in atherosclerosis. Circulation Research 126 (9):1209–1227. https://doi.org/10.1161/CIRCRESAHA.119.315939.

Back M., A. Yurdagul, Jr., I. Tabas, K. Oorni, P. T. Kovanen. 2019. Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities. Nature Reviews Cardiology 16 (7):389–406. https://doi.org/10.1038/s41569-019-0169-2.

Libby P., G. Pasterkamp, F. Crea, I. K. Jang. 2019. Reassessing the mechanisms of acute coronary syndromes. Circulation Research 124 (1):150–160. https://doi.org/10.1161/CIRCRESAHA.118.311098.

Doddapattar P., R. Dev, M. Ghatge, R. B. Patel, M. Jain, N. Dhanesha, S. R. Lentz, A. K. Chauhan. 2022. Myeloid cell PKM2 deletion enhances efferocytosis and reduces atherosclerosis. Circulation Research 130 (9):1289–1305. https://doi.org/10.1161/CIRCRESAHA.121.320704.

Malaer J. D., A. M. Marrufo, P. A. Mathew. 2019. 2B4 (CD244, SLAMF4) and CS1 (CD319, SLAMF7) in systemic lupus erythematosus and cancer. Clinical Immunology 204:50–56. https://doi.org/10.1016/j.clim.2018.10.009.

Cannons J. L., S. G. Tangye, P. L. Schwartzberg. 2011. SLAM family receptors and SAP adaptors in immunity. Annual Review of Immunology 29:665–705. https://doi.org/10.1146/annurev-immunol-030409-101302.

Lonial S., M. Dimopoulos, A. Palumbo, D. White, S. Grosicki, I. Spicka, A. Walter-Croneck, P. Moreau, M. V. Mateos, H. Magen, A. Belch, D. Reece, M. Beksac, A. Spencer, H. Oakervee, R. Z. Orlowski, M. Taniwaki, C. Rollig, H. Einsele, K. L. Wu, A. Singhal, J. San-Miguel, M. Matsumoto, J. Katz, E. Bleickardt, V. Poulart, K. C. Anderson, P. Richardson, E.-. Investigators. 2015. Elotuzumab therapy for relapsed or refractory multiple myeloma. The New England Journal of Medicine 373 (7):621–631. https://doi.org/10.1056/NEJMoa1505654.

O’Neal J., J. K. Ritchey, M. L. Cooper, J. Niswonger, L. Sofia Gonzalez, E. Street, M. P. Rettig, S. W. Gladney, L. Gehrs, R. Abboud, J. L. Prior, G. J. Haas, R. G. Jayasinghe, L. Ding, A. Ghobadi, R. Vij, J. F. DiPersio. 2022. CS1 CAR-T targeting the distal domain of CS1 (SLAMF7) shows efficacy in high tumor burden myeloma model despite fratricide of CD8+CS1 expressing CAR-T cells. Leukemia 36 (6):1625–1634. https://doi.org/10.1038/s41375-022-01559-4.

O’Connell P., M. K. Blake, S. Godbehere, A. Amalfitano, Y. A. Aldhamen. 2022. SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity. Journal of Neuroinflammation 19 (1):241. https://doi.org/10.1186/s12974-022-02594-9.

Comte D., M. P. Karampetsou, N. Yoshida, K. Kis-Toth, V. C. Kyttaris, G. C. Tsokos. 2017. Signaling lymphocytic activation molecule family member 7 engagement restores defective effector CD8+ T cell function in systemic lupus erythematosus. Arthritis Rheumatology 69 (5):1035–1044. https://doi.org/10.1002/art.40038.

O’Connell P., Y. Pepelyayeva, M. K. Blake, S. Hyslop, R. B. Crawford, M. D. Rizzo, C. Pereira-Hicks, S. Godbehere, L. Dale, P. Gulick, N. E. Kaminski, A. Amalfitano, Y. A. Aldhamen. 2019. SLAMF7 is a critical negative regulator of IFN-alpha-mediated CXCL10 production in chronic HIV infection. The Journal of Immunology 202 (1):228–238. https://doi.org/10.4049/jimmunol.1800847.

Wu Y., Q. Wang, M. Li, J. Lao, H. Tang, S. Ming, M. Wu, S. Gong, L. Li, L. Liu, X. Huang. 2023. SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis. The Journal of Clinical Investigation 133 (6). https://doi.org/10.1172/jci150224.

Zhu S., Y. Chen, J. Lao, C. Wu, X. Zhan, Y. Wu, Y. Shang, Z. Zou, J. Zhou, X. Ji, X. Huang, X. Shi, M. Wu. 2021. Signaling lymphocytic activation molecule family-7 alleviates corneal inflammation by promoting M2 polarization. The Journal of Infectious Diseases 223 (5):854–865. https://doi.org/10.1093/infdis/jiaa445.

Simmons D. P., H. N. Nguyen, E. Gomez-Rivas, Y. Jeong, A. H. Jonsson, A. F. Chen, J. K. Lange, G. S. Dyer, P. Blazar, B. E. Earp, J. S. Coblyn, E. M. Massarotti, J. A. Sparks, D. J. Todd, R. A. S. L. E. N. Accelerating Medicines Partnership, D. A. Rao, E. Y. Kim, M. B. Brenner. 2022. SLAMF7 engagement superactivates macrophages in acute and chronic inflammation. Science Immunology 7 (68):eabf2846. https://doi.org/10.1126/sciimmunol.abf2846.

Xia, Z.G.M., X. Jia, X. Wang, C. Wu, J. Guo, L. Zhang, Y. Du, and J. Wang. 2018. Integrated DNA methylation and gene expression analysis identifies SLAMF7 as a key regulator of atherosclerosis. Aging 10 (6): 1324–1337.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang C., W. Yang, X. Liang, W. Song, J. Lin, Y. Sun, X. Guan. 2020. MicroRNA-761 modulates foam cell formation and inflammation through autophagy in the progression of atherosclerosis. Molecular and Cellular Biochemistry 474 (1–2):135–146. https://doi.org/10.1007/s11010-020-03839-y.

Fang S., X. Wan, X. Zou, S. Sun, X. Hao, C. Liang, Z. Zhang, F. Zhang, B. Sun, H. Li, B. Yu. 2021. Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway. Cell Death & Disease 12 (1):88. https://doi.org/10.1038/s41419-020-03357-1.

Fu X., X. Yu, J. Jiang, J. Yang, L. Chen, Z. Yang, C. Yu. 2022. Small molecule-assisted assembly of multifunctional ceria nanozymes for synergistic treatment of atherosclerosis. Nature Communications 13 (1):6528. https://doi.org/10.1038/s41467-022-34248-y.

Yang Z., Y. Huang, L. Zhu, K. Yang, K. Liang, J. Tan, B. Yu. 2021. SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1alpha and reactive oxygen species. Cell Death & Disease 12 (1):77. https://doi.org/10.1038/s41419-020-03372-2.

Zhang K., J. Zheng, Y. Chen, J. Dong, Z. Li, Y. P. Chiang, M. He, Q. Huang, H. Tang, X. C. Jiang. 2021. Inducible phospholipid transfer protein deficiency ameliorates atherosclerosis. Atherosclerosis 324:9–17. https://doi.org/10.1016/j.atherosclerosis.2021.03.011.

Andrews S. 2010. FastQC: a quality control tool for high throughput sequence data. Babraham Bioinformatics, Babraham Institute, Cambridge, United Kingdom,

Liao Y., G. K. Smyth, W. Shi. 2014. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics (Oxford, England) 30 (7):923–930. https://doi.org/10.1093/bioinformatics/btt656.

Love M. I., W. Huber, S. Anders. 2014. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology 15 (12):550. https://doi.org/10.1186/s13059-014-0550-8.

Benjamini Y., Y. J. J. o. t. R. s. s. s. B. Hochberg. 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing. 57 (1):289–300.

Johnston JM A. A., Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M; Cardiogenics Consortium; Wilson HL, Goodall AH, Rader DJ, Shoulders CC, Francis SE, Kiss-Toth E. 2019. Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion. Science Advances 5 (10):eaax9183.

Li H., Z. Cao, L. Wang, C. Liu, H. Lin, Y. Tang, P. Yao. 2022. Macrophage subsets and death are responsible for atherosclerotic plaque formation. Front Immunology 13:843712. https://doi.org/10.3389/fimmu.2022.843712.

Schwarz N., S. Fernando, Y. C. Chen, T. Salagaras, S. R. Rao, S. Liyanage, A. E. Williamson, D. Toledo-Flores, C. Dimasi, T. J. Sargeant, J. Manavis, E. Eddy, P. Kanellakis, P. L. Thompson, J. T. M. Tan, M. F. Snel, C. A. Bursill, S. J. Nicholls, K. Peter, P. J. Psaltis. 2023. Colchicine exerts anti-atherosclerotic and -plaque-stabilizing effects targeting foam cell formation. FASEB Journal 37 (4):e22846. https://doi.org/10.1096/fj.202201469R.

Hanna R. N., I. Shaked, H. G. Hubbeling, J. A. Punt, R. Wu, E. Herrley, C. Zaugg, H. Pei, F. Geissmann, K. Ley, C. C. Hedrick. 2012. NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis. Circulation Research 110 (3):416–427. https://doi.org/10.1161/CIRCRESAHA.111.253377.

Hamers A. A., M. Vos, F. Rassam, G. Marinkovic, K. Kurakula, P. J. van Gorp, M. P. de Winther, M. J. Gijbels, V. de Waard, C. J. de Vries. 2012. Bone marrow-specific deficiency of nuclear receptor Nur77 enhances atherosclerosis. Circulation Research 110 (3):428–438. https://doi.org/10.1161/CIRCRESAHA.111.260760.

Koenis D. S., L. Medzikovic, P. B. van Loenen, M. van Weeghel, S. Huveneers, M. Vos, I. J. Evers-van Gogh, J. Van den Bossche, D. Speijer, Y. Kim, L. Wessels, N. Zelcer, W. Zwart, E. Kalkhoven, C. J. de Vries. 2018. Nuclear receptor Nur77 limits the macrophage inflammatory response through transcriptional reprogramming of mitochondrial metabolism. Cell Reports 24 (8):2127–2140 e2127. https://doi.org/10.1016/j.celrep.2018.07.065.

Nowyhed H. N., T. R. Huynh, A. Blatchley, R. Wu, G. D. Thomas, C. C. Hedrick. 2015. The nuclear receptor nr4a1 controls CD8 T cell development through transcriptional suppression of runx3. Scientific Reports 5:9059. https://doi.org/10.1038/srep09059.

Song P., Z. Fang, H. Wang, Y. Cai, K. Rahimi, Y. Zhu, F. G. R. Fowkes, F. J. I. Fowkes, I. Rudan. 2020. Global and regional prevalence, burden, and risk factors for carotid atherosclerosis: a systematic review, meta-analysis, and modelling study. Lancet Global Health 8 (5):e721-e729. https://doi.org/10.1016/S2214-109X(20)30117-0.

Lin H. P., B. Singla, W. Ahn, P. Ghoshal, M. Blahove, M. Cherian-Shaw, A. Chen, A. Haller, D. Y. Hui, K. Dong, J. Zhou, J. White, A. M. Stranahan, A. Jasztal, R. Lucas, B. K. Stansfield, D. Fulton, S. Chlopicki, G. Csanyi. 2022. Receptor-independent fluid-phase macropinocytosis promotes arterial foam cell formation and atherosclerosis. Science Translational Medicine 14 (663):eadd2376. https://doi.org/10.1126/scitranslmed.add2376.

Liu X., J. W. Guo, X. C. Lin, Y. H. Tuo, W. L. Peng, S. Y. He, Z. Q. Li, Y. C. Ye, J. Yu, F. R. Zhang, M. M. Ma, J. Y. Shang, X. F. Lv, A. D. Zhou, Y. Ouyang, C. Wang, R. P. Pang, J. X. Sun, J. S. Ou, J. G. Zhou, S. J. Liang. 2021. Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms. European Heart Journal 42 (47):4847–4861. https://doi.org/10.1093/eurheartj/ehab660.

Wang D., Y. Yang, Y. Lei, N. T. Tzvetkov, X. Liu, A. W. K. Yeung, S. Xu, A. G. Atanasov. 2019. Targeting foam cell formation in atherosclerosis: therapeutic potential of natural products. Pharmacological Reviews 71 (4):596–670. https://doi.org/10.1124/pr.118.017178.

Wang B., X. Tang, L. Yao, Y. Wang, Z. Chen, M. Li, N. Wu, D. Wu, X. Dai, H. Jiang, D. Ai. 2022. Disruption of USP9X in macrophages promotes foam cell formation and atherosclerosis. Journal of Clinical Investigation 132 (10). https://doi.org/10.1172/JCI154217.

Pi S., L. Mao, J. Chen, H. Shi, Y. Liu, X. Guo, Y. Li, L. Zhou, H. He, C. Yu, J. Liu, Y. Dang, Y. Xia, Q. He, H. Jin, Y. Li, Y. Hu, Y. Miao, Z. Yue, B. Hu. 2021. The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis. Autophagy 17 (4):980–1000. https://doi.org/10.1080/15548627.2020.1741202.

Spann N. J., L. X. Garmire, J. G. McDonald, D. S. Myers, S. B. Milne, N. Shibata, D. Reichart, J. N. Fox, I. Shaked, D. Heudobler, C. R. Raetz, E. W. Wang, S. L. Kelly, M. C. Sullards, R. C. Murphy, A. H. Merrill, Jr., H. A. Brown, E. A. Dennis, A. C. Li, K. Ley, S. Tsimikas, E. Fahy, S. Subramaniam, O. Quehenberger, D. W. Russell, C. K. Glass. 2012. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell 151 (1):138–152. https://doi.org/10.1016/j.cell.2012.06.054.

Engelen S. E., A. J. B. Robinson, Y. X. Zurke, C. Monaco. 2022. Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed? Nature Reviews Cardiology 19 (8):522–542. https://doi.org/10.1038/s41569-021-00668-4.

Jinnouchi H., L. Guo, A. Sakamoto, S. Torii, Y. Sato, A. Cornelissen, S. Kuntz, K. H. Paek, R. Fernandez, D. Fuller, N. Gadhoke, D. Surve, M. Romero, F. D. Kolodgie, R. Virmani, A. V. Finn. 2020. Diversity of macrophage phenotypes and responses in atherosclerosis. Cellular and Molecular Life Sciences 77 (10):1919–1932. https://doi.org/10.1007/s00018-019-03371-3.

Ruosen Y., W. Zhang, P. Nie, K. Lan, X. Yang, A. Yin, Q. Xiao, Y. Shen, K. Xu, X. Wang, X. Pan, L. Shen, B. He. 2022. Nur77 deficiency exacerbates macrophage NLRP3 inflammasome-mediated inflammation and accelerates atherosclerosis. Oxidative Medicine and Cellular Longevity 2022:2017815. https://doi.org/10.1155/2022/2017815.

Nus M., G. Basatemur, M. Galan, L. Cros-Brunso, T. X. Zhao, L. Masters, J. Harrison, N. Figg, D. Tsiantoulas, F. Geissmann, C. J. Binder, A. P. Sage, Z. Mallat. 2020. NR4A1 deletion in marginal zone B cells exacerbates atherosclerosis in mice-brief report. Arteriosclerosis, Thrombosis, and Vascular Biology 40 (11):2598–2604. https://doi.org/10.1161/ATVBAHA.120.314607.

Bao M. H., H. Q. Luo, L. H. Chen, L. Tang, K. F. Ma, J. Xiang, L. P. Dong, J. Zeng, G. Y. Li, J. M. Li. 2016. Impact of high fat diet on long non-coding RNAs and messenger RNAs expression in the aortas of ApoE(-/-) mice. Scientific Reports 6:34161. https://doi.org/10.1038/srep34161.

Su Z., H. Lu, H. Jiang, H. Zhu, Z. Li, P. Zhang, P. Ni, H. Shen, W. Xu, H. Xu. 2015. IFN-gamma-producing Th17 cells bias by HMGB1-T-bet/RUNX3 axis might contribute to progression of coronary artery atherosclerosis. Atherosclerosis 243 (2):421–428. https://doi.org/10.1016/j.atherosclerosis.2015.09.037.

Shao Y., F. Saaoud, W. Cornwell, K. Xu, A. Kirchhoff, Y. Lu, X. Jiang, H. Wang, T. J. Rogers, X. Yang. 2022. Cigarette smoke and morphine promote treg plasticity to Th17 via enhancing trained immunity. Cells 11 (18). https://doi.org/10.3390/cells11182810.

Dybska E., J. K. Nowak, J. Walkowiak. 2023. Transcriptomic context of RUNX3 expression in monocytes: a cross-sectional analysis. Biomedicines 11 (6). https://doi.org/10.3390/biomedicines11061698.

留言 (0)

沒有登入
gif