Catapol attenuates the aseptic inflammatory response to hepatic I/R injury in vivo and in vitro by inhibiting the HMGB1/TLR-4/NF-κB signaling pathway via the microRNA-410–3p

AbbreviationsALT

alanine aminotransferase

AST

aspartate aminotransferase CAT, Catalpol

HMGB1

high-mobility group protein B1

IL-1β

Interleukin – 1β

IκB-α

inhibitor of NF-kappa B-α

MyD88

myeloid differentiation factor 88

p-NF-κB

Phospho-Nuclear factor κB

p-IκB-α

Phospho-Inhibitor of NF-kappa B-a

ROS

reactive oxygen species

TNF-α

tumor necrosis factor α

TLR-4

toll like receptor-4

KeyWords

Catalpol

Hepatic ischaemia-reperfusion injury

HMGB1

Sterile inflammatory response

MicroRNA

Data availability

I have put the experimental data link address in the supplementary materials section of the manuscript.

View original article

0 0 0 0 0 0 0

留言 (0)