Characteristics of esophageal refluxate and symptoms in infants compared between pre-treatment and on treatment with proton pump inhibitors

Vandenplas Y, Rudolph CD, Di Lorenzo C, Hassall E, Liptak G, Mazur L, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr. 2009;49:498–547.

Article  PubMed  Google Scholar 

Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for pediatric gastroenterology, hepatology, and nutrition and the european society for pediatric gastroenterology, hepatology, and nutrition. J Pediatr Gastroenterol Nutr. 2018;66:516–54.

Article  PubMed  PubMed Central  Google Scholar 

Orenstein SR, McGowan JD. Efficacy of conservative therapy as taught in the primary care setting for symptoms suggesting infant gastroesophageal reflux. J Pediatr. 2008;152:310–4.

Article  PubMed  Google Scholar 

Sultana Z, Hasenstab KA, Moore RK, Osborn EK, Yildiz VO, Wei L, et al. Symptom scores and pH-Impedance: secondary analysis of a randomized controlled trial in infants treated for gastroesophageal reflux. Gastro Hep Adv. 2022;1:869–81.

Article  PubMed  PubMed Central  Google Scholar 

Levy EI, Salvatore S, Vandenplas Y, de Winter JP. Prescription of acid inhibitors in infants: an addiction hard to break. Eur J Pediatr. 2020;179:1957–61.

Article  PubMed  Google Scholar 

Jadcherla SR, Sultana Z, Hasenstab-Kenney KA, Prabhakar V, Gulati IK, Di Lorenzo C. Differentiating esophageal sensitivity phenotypes using pH-impedance in intensive care unit infants referred for gastroesophageal reflux symptoms. Pediatr Res. 2021;89:636–44.

Article  PubMed  Google Scholar 

Jadcherla SR, Slaughter JL, Stenger MR, Klebanoff M, Kelleher K, Gardner W. practice variance, prevalence, and economic burden of premature infants diagnosed with GERD. Hosp Pediatr. 2013;3:335–41.

Article  PubMed  PubMed Central  Google Scholar 

Corsonello A, Lattanzio F, Bustacchini S, Garasto S, Cozza A, Schepisi R, et al. Adverse events of proton pump inhibitors: potential mechanisms. Curr Drug Metab. 2018;19:142–54.

Article  PubMed  Google Scholar 

Slaughter JL, Stenger MR, Reagan PB, Jadcherla SR. Neonatal Histamine-2 receptor antagonist and proton pump inhibitor treatment at United States Children’s Hospitals. J Pediatr. 2016;174:63–70.e3.

Article  PubMed  PubMed Central  Google Scholar 

Davidson G, Wenzl TG, Thomson M, Omari T, Barker P, Lundborg P, et al. Efficacy and safety of once-daily esomeprazole for the treatment of gastroesophageal reflux disease in neonatal patients. J Pediatr. 2013;163:692–8.e1-2.

Article  PubMed  Google Scholar 

Loots CM, Benninga MA, Davidson GP, Omari TI. Addition of pH-impedance monitoring to standard pH monitoring increases the yield of symptom association analysis in infants and children with gastroesophageal reflux. J Pediatr. 2009;154:248–52.

Article  PubMed  Google Scholar 

Woodley FW, Moore-Clingenpeel M, Machado RS, Nemastil CJ, Jadcherla SR, Hayes D Jr, et al. Not all children with cystic fibrosis have abnormal esophageal neutralization during chemical clearance of acid reflux. Pediatr Gastroenterol Hepatol Nutr. 2017;20:153–9.

Article  PubMed  PubMed Central  Google Scholar 

Gyawali CP, Kahrilas PJ, Savarino E, Zerbib F, Mion F, Smout A, et al. Modern diagnosis of GERD: the Lyon Consensus. Gut. 2018;67:1351–62.

Article  PubMed  Google Scholar 

Sivalingam M, Sitaram S, Hasenstab KA, Wei L, Woodley FW, Jadcherla SR. Effects of esophageal acidification on troublesome symptoms: an approach to characterize true acid GERD in dysphagic neonates. Dysphagia. 2017;32:509–19.

Article  PubMed  PubMed Central  Google Scholar 

Jadcherla SR, Hanandeh N, Hasenstab KA, Nawaz S. Differentiation of esophageal pH-impedance characteristics classified by the mucosal integrity marker in human neonates. Pediatr Res. 2019;85:355–60.

Article  PubMed  Google Scholar 

Jadcherla SR, Peng J, Chan CY, Moore R, Wei L, Fernandez S, et al. Significance of gastroesophageal refluxate in relation to physical, chemical, and spatiotemporal characteristics in symptomatic intensive care unit neonates. Pediatr Res. 2011;70:192–8.

Article  PubMed  PubMed Central  Google Scholar 

Weusten BL, Roelofs JM, Akkermans LM, Van Berge-Henegouwen GP, Smout AJ. The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data. Gastroenterology. 1994;107:1741–5.

Article  PubMed  Google Scholar 

Frazzoni M, Savarino E, de Bortoli N, Martinucci I, Furnari M, Frazzoni L, et al. Analyses of the post-reflux swallow-induced peristaltic wave index and nocturnal baseline impedance parameters increase the diagnostic yield of impedance-pH monitoring of patients with reflux disease. Clin Gastroenterol Hepatol. 2016;14:40–6.

Article  PubMed  Google Scholar 

Frazzoni M, de Bortoli N, Frazzoni L, Tolone S, Furnari M, Martinucci I, et al. The added diagnostic value of postreflux swallow-induced peristaltic wave index and nocturnal baseline impedance in refractory reflux disease studied with on-therapy impedance-pH monitoring. Neurogastroenterol Motil. 2017;29:e12947.

Castellani C, Huber-Zeyringer A, Bachmaier G, Saxena AK, Hollwarth ME. Proton pump inhibitors for reflux therapy in infants: effectiveness determined by impedance pH monitoring. Pediatr Surg Int. 2014;30:381–5.

Article  PubMed  Google Scholar 

Hemmink GJ, Bredenoord AJ, Weusten BL, Monkelbaan JF, Timmer R, Smout AJ. Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: ‘on’ or ‘off’ proton pump inhibitor? Am J Gastroenterol. 2008;103:2446–53.

Article  PubMed  Google Scholar 

Turk H, Hauser B, Brecelj J, Vandenplas Y, Orel R. Effect of proton pump inhibition on acid, weakly acid and weakly alkaline gastro-esophageal reflux in children. World J Pediatr. 2013;9:36–41.

Article  PubMed  Google Scholar 

Gibbons TE, Gold BD. The use of proton pump inhibitors in children: a comprehensive review. Paediatr Drugs. 2003;5:25–40.

Article  PubMed  Google Scholar 

Welsh C, Kasirer MY, Pan J, Shifrin Y, Belik J. Pantoprazole decreases gastroesophageal muscle tone in newborn rats via rho-kinase inhibition. Am J Physiol Gastrointest Liver Physiol. 2014;307:G390–6.

Article  PubMed  Google Scholar 

Mitchell DJ, McClure BG, Tubman TR. Simultaneous monitoring of gastric and oesophageal pH reveals limitations of conventional oesophageal pH monitoring in milk fed infants. Arch Dis Child. 2001;84:273–6.

Article  PubMed  PubMed Central  Google Scholar 

Borrelli O, Salvatore S, Mancini V, Ribolsi M, Gentile M, Bizzarri B, et al. Relationship between baseline impedance levels and esophageal mucosal integrity in children with erosive and non-erosive reflux disease. Neurogastroenterol Motil. 2012;24:828–e394.

Article  PubMed  Google Scholar 

Jadcherla SR, Helmick R, Hasenstab KA, Njeh M, Alshaikh E. Impact of esophageal mucosal permeability markers on provocation-induced esophageal reflexes in high-risk infants. Physiol Rep. 2022;10:e15366.

Article  PubMed  PubMed Central  Google Scholar 

Cohen Sabban J, Bertoldi GD, Ussher F, Christiansen S, Lifschitz C, Orsi M. Low-impedance baseline values predict severe esophagitis. J Pediatr Gastroenterol Nutr. 2017;65:278–80.

Article  PubMed  Google Scholar 

Xu H, Ye B, Ding Y, Wang M, Lin L, Jiang L. Factors of reflux episodes with post-reflux swallow-induced peristaltic wave in gastroesophageal reflux disease. J Neurogastroenterol Motil. 2020;26:378–83.

Article  PubMed  PubMed Central  Google Scholar 

Frazzoni M, Manta R, Mirante VG, Conigliaro R, Frazzoni L, Melotti G. Esophageal chemical clearance is impaired in gastro-esophageal reflux disease-a 24-h impedance-pH monitoring assessment. Neurogastroenterol Motil. 2013;25:399–406.e295.

Article  PubMed  Google Scholar 

Gupta A, Gulati P, Kim W, Fernandez S, Shaker R, Jadcherla SR. Effect of postnatal maturation on the mechanisms of esophageal propulsion in preterm human neonates: primary and secondary peristalsis. Am J Gastroenterol. 2009;104:411–9.

Article  PubMed  PubMed Central  Google Scholar 

Jadcherla SR, Duong HQ, Hoffmann RG, Shaker R. Esophageal body and upper esophageal sphincter motor responses to esophageal provocation during maturation in preterm newborns. J Pediatr. 2003;143:31–8.

Article  PubMed  Google Scholar 

Collins CR, Hasenstab KA, Nawaz S, Jadcherla SR. Mechanisms of aerodigestive symptoms in infants with varying acid reflux index determined by esophageal manometry. J Pediatr. 2019;206:240–7.

Article  PubMed  Google Scholar 

Zerbib F, Duriez A, Roman S, Capdepont M, Mion F. Determinants of gastro-oesophageal reflux perception in patients with persistent symptoms despite proton pump inhibitors. Gut. 2008;57:156–60.

Article  PubMed  Google Scholar 

Herregods TV, Bredenoord AJ, Smout AJ. Pathophysiology of gastroesophageal reflux disease: new understanding in a new era. Neurogastroenterol Motil. 2015;27:1202–13.

Article  PubMed  Google Scholar 

Zoizner-Agar G, Rotsides JM, Shao Q, Rickert S, Ward R, Greifer M, et al. Proton pump inhibitor administration in neonates and infants. Lack of consensus - An ASPO survey. Int J Pediatr Otorhinolaryngol. 2020;137:110200.

Article  PubMed  Google Scholar 

Safe M, Chan WH, Leach ST, Sutton L, Lui K, Krishnan U. Widespread use of gastric acid inhibitors in infants: Are they needed? Are they safe? World J Gastrointest Pharm Ther. 2016;7:531–9.

Article  Google Scholar 

Eichenwald EC, Committee On F, Newborn. Diagnosis and Management of Gastroesophageal Reflux in Preterm Infants. Pediatrics. 2018;142:e20181061.

Jadcherla SR, Hasenstab KA, Gulati IK, Helmick R, Ipek H, Yildiz V, et al. Impact of feeding strategies with acid suppression on esophageal reflexes in human neonates with gastroesophageal reflux disease: a single-blinded randomized clinical trial. Clin Transl Gastroenterol. 2020;11:e00249.

Article  PubMed  PubMed Central 

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