Younossi Z, Tacke F, Arrese M, Chander Sharma B, Mostafa I, Bugianesi E, et al. Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Hepatology. 2019;69(6):2672–82.

Article  PubMed  Google Scholar 

Paik JM, Golabi P, Younossi Y, Mishra A, Younossi ZM. Changes in the global burden of chronic liver diseases from 2012 to 2017: the growing impact of NAFLD. Hepatology. 2020;72(5):1605–16.

Article  PubMed  Google Scholar 

Eslam M, Newsome PN, Sarin SK, Anstee QM, Targher G, Romero-Gomez M, et al. A new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement. J Hepatol. 2020;73(1):202–9.

Article  PubMed  Google Scholar 

Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, et al. A multi-society Delphi consensus statement on new fatty liver disease nomenclature. J Hepatol. 2023.

Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, Abdelmalek MF, Caldwell S, Barb D, et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797–835.

Article  PubMed  Google Scholar 

Wang J, He W, Tsai P-J, Chen P-H, Ye M, Guo J, et al. Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease. Lipids Health Dis. 2020;19(1):1–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jennison E, Patel J, Scorletti E, Byrne CD. Diagnosis and management of non-alcoholic fatty liver disease. Postgrad Med J. 2019;95(1124):314–22.

Article  PubMed  Google Scholar 

Green CJ, Parry SA, Gunn PJ, Ceresa CD, Rosqvist F, Piché M-E, et al. Studying non-alcoholic fatty liver disease: the ins and outs of in vivo, ex vivo and in vitro human models. Horm Mol Biol Clin Investig. 2020;41(1).

Younossi ZM, Blissett D, Blissett R, Henry L, Stepanova M, Younossi Y, et al. The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe. Hepatology. 2016;64(5):1577–86.

Article  PubMed  Google Scholar 

Charlton M. Nonalcoholic fatty liver disease: a review of current understanding and future impact. Clin Gastroenterol Hepatol. 2004;2(12):1048–58.

Article  PubMed  Google Scholar 

Charlton MR, Burns JM, Pedersen RA, Watt KD, Heimbach JK, Dierkhising RA. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology. 2011;141(4):1249–53.

Article  PubMed  Google Scholar 

Glen J, Floros L, Day C, Pryke R. Non-alcoholic fatty liver disease (NAFLD): summary of NICE guidance. BMJ. 2016;354:i4428.

Article  PubMed  Google Scholar 

Riazi K, Raman M, Taylor L, Swain MG, Shaheen AA. Dietary patterns and components in Nonalcoholic Fatty Liver Disease (NAFLD): what key messages can health care providers offer? Nutrients. 2019;11(12):2878.

Article  PubMed  PubMed Central  Google Scholar 

Lombardi R, Iuculano F, Pallini G, Fargion S, Fracanzani AL. Nutrients, genetic factors, and their interaction in non-alcoholic fatty liver disease and cardiovascular disease. Int J Mol Sci. 2020;21(22):8761.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Umpleby AM, Shojaee-Moradie F, Fielding B, Li X, Marino A, Alsini N, et al. Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets. Clin Sci (Lond). 2017;131(21):2561–73.

Article  CAS  PubMed  Google Scholar 

Gao Y, Hua R, Hu K, Wang Z. Carbohydrates deteriorate fatty liver by activating the inflammatory response. Nutr Res Rev. 2021:1-48.

Yki-Järvinen H, Luukkonen PK, Hodson L, Moore JB. Dietary carbohydrates and fats in non-alcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. 2021:1-17.

Kwon OW, Jun DW, Lee SM, Lee KN, Lee HL, Lee OY, et al. Carbohydrate but not fat is associated with elevated aminotransferases. Aliment Pharmacol Ther. 2012;35(9):1064–72.

CAS  PubMed  Google Scholar 

Tajima R, Kimura T, Enomoto A, Yanoshita K, Saito A, Kobayashi S, et al. Association between rice, bread, and noodle intake and the prevalence of non-alcoholic fatty liver disease in Japanese middle-aged men and women. Clin Nutr. 2017;36(6):1601–8.

Article  PubMed  Google Scholar 

Honarvar B, BagheriLankarani K, Keshani P, Rafiee T. Dietary determinants of non-alcoholic fatty liver disease in lean and non-lean adult patients: a population-based study in Shiraz, Southern Iran. Hepat Mon. 2017;17(4):e12295.

Article  Google Scholar 

Mosallaei Z, Mazidi M, Safariyan M, Norouzy A, Mohajeri SAR, Esmaily H, et al. Dietary intake and its relationship with non-alcoholic fatty liver disease (NAFLD). Med J Nutrition Metab. 2015;8(2):139–48.

Google Scholar 

Georgoulis M, Kontogianni MD, Tileli N, Margariti A, Fragopoulou E, Tiniakos D, et al. The impact of cereal grain consumption on the development and severity of non-alcoholic fatty liver disease. Eur J Nutr. 2014;53(8):1727–35.

Article  CAS  PubMed  Google Scholar 

Rietman A, Sluik D, Feskens EJM, Kok FJ, Mensink M. Associations between dietary factors and markers of NAFLD in a general Dutch adult population. Eur J Clin Nutr. 2018;72(1):117–23.

Article  CAS  PubMed  Google Scholar 

Noureddin M, Zelber-Sagi S, Wilkens LR, Porcel J, Boushey CJ, Le Marchand L, et al. Diet associations with nonalcoholic fatty liver disease in an ethnically diverse population: the multiethnic cohort. Hepatology. 2020;71(6):1940–52.

Article  CAS  PubMed  Google Scholar 

Goletzke J, Buyken AE, Gopinath B, Rochtchina E, Barclay AW, Cheng G, et al. Carbohydrate quality is not associated with liver enzyme activity and plasma TAG and HDL concentrations over 5 years in an older population. Br J Nutr. 2012;110(5):918–25.

Article  Google Scholar 

Cantoral A, Contreras-Manzano A, Luna-Villa L, Batis C, Roldán-Valadez EA, Ettinger AS, et al. Dietary sources of fructose and its association with fatty liver in mexican young adults. nutrients. 2019;11(3):522.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li C, Guo P, Okekunle AP, Ji X, Huang M, Qi J, et al. Lean non-alcoholic fatty liver disease patients had comparable total caloric, carbohydrate, protein, fat, iron, sleep duration and overtime work as obese non-alcoholic fatty liver disease patients. J Gastroenterol Hepatol. 2019;34(1):256–62.

Article  CAS  PubMed  Google Scholar 

Bhatt SP, Misra A, Nigam P. Nutrition and physical activity in Asian Indians with non-alcoholic fatty liver: a case control study. Diabetes Metab Syndr  Clin Res Rev. 2019;13(2):1271–4.

Article  Google Scholar 

Alferink LJM, Kiefte-De Jong JC, Erler NS, Veldt BJ, Schoufour JD, De Knegt RJ, et al. Association of dietary macronutrient composition and non-alcoholic fatty liver disease in an ageing population: The Rotterdam Study. Gut. 2019;68(6):1088–98.

Article  CAS  PubMed  Google Scholar 

Tsompanaki E, Thanapirom K, Papatheodoridi M, Parikh P, de Lima YC, Tsochatzis EA. Systematic review and meta-analysis: the role of diet in the development of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2021.

Starekova J, Hernando D, Pickhardt PJ, Reeder SB. Quantification of liver fat content with CT and MRI: state of the art. Radiology. 2021;301(2):250–62.

Article  PubMed  Google Scholar 

Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12(3):e1001779.

Article  PubMed  PubMed Central  Google Scholar 

UK Biobank Resource 100227: Blood sampling procedures using ACE 2011. Available from: https://biobank.ndph.ox.ac.uk/showcase/refer.cgi?id=100227.

Littlejohns TJ, Holliday J, Gibson LM, Garratt S, Oesingmann N, Alfaro-Almagro F, et al. The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions. Nat Commun. 2020;11(1):1–12.

Article  Google Scholar 

UK Biobank Study Protocol. Protocol for a large-scale prospective epidemiological resource. Available from: https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/about-us.

UK Biobank Resource 118240: 24-hour dietary recall questionnaire 2012. Available from: https://biobank.ndph.ox.ac.uk/showcase/refer.cgi?id=118240.

Liu B, Young H, Crowe FL, Benson VS, Spencer EA, Key TJ, et al. Development and evaluation of the Oxford WebQ, a low-cost, web-based method for assessment of previous 24 h dietary intakes in large-scale prospective studies. Public Health Nutr. 2011;14(11):1998–2005.

Article  PubMed  Google Scholar 

Greenwood DC, Hardie LJ, Frost GS, Alwan NA, Bradbury KE, Carter M, et al. Validation of the Oxford WebQ online 24-hour dietary questionnaire using biomarkers. Am J Epidemiol. 2019;188(10):1858–67.

Article  PubMed  PubMed Central  Google Scholar 

Perez-Cornago A, Pollard Z, Young H, van Uden M, Andrews C, Piernas C, et al. Description of the updated nutrition calculation of the Oxford WebQ questionnaire and comparison with the previous version among 207,144 participants in UK Biobank. Eur J Nutr. 2021:1-12.

Swan GE, Powell NA, Knowles BL, Bush MT, Levy LB. A definition of free sugars for the UK. Public Health Nutr. 2018;21(9):1636–8.

Article  PubMed  PubMed Central  Google Scholar 

Public Health England SACN Carbohydrates and Health Report 2015. Available from: https://www.gov.uk/government/publications/sacn-carbohydrates-and-health-report.

Lee J-H, Kim D, Kim HJ, Lee C-H, Yang JI, Kim W, et al. Hepatic steatosis index: a simple screening tool reflecting nonalcoholic fatty liver disease. Dig Liver Dis. 2010;42(7):503–8.

Article  CAS  PubMed  Google Scholar 

Chen L-D, Huang J-F, Chen Q-S, Lin G-F, Zeng H-X, Lin X-F, et al. Validation of fatty liver index and hepatic steatosis index for screening of non-alcoholic fatty liver disease in adults with obstructive sleep apnea hypopnea syndrome. Chin Med J. 2019;132(22):2670–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sviklāne L, Olmane E, Dzērve Z, Kupčs K, Pīrāgs V, Sokolovska J. Fatty liver index and hepatic steatosis index for prediction of non-alcoholic fatty liver disease in type 1 diabetes. J Gastroenterol Hepatol. 2018;33(1):270–6.

Article  PubMed  Google Scholar 

Fennoun H, El Mansouri S, Tahiri M, Haraj NE, El Aziz S, Hadad F, et al. Interest of hepatic steatosis index (HSI) in screening for metabolic steatopathy in patients with type 2 diabetes. Pan Afr Med J. 2020;37:270.

PubMed  PubMed Central  Google Scholar