Influence of thyroid autoimmunity at various clinical stages of hypothyroidism on the risk of miscarriage before 20 weeks of gestation

Ahmed IZ, Eid YM, El Orabi H, Ibrahim HR (2014) Comparison of universal and targeted screening for thyroid dysfunction in pregnant Egyptian women. Eur J Endocrinol 171(2):285–291. https://doi.org/10.1530/EJE-14-0100

Article  CAS  PubMed  Google Scholar 

Godines-Enriquez MS, Miranda-Velásquez S, Enríquez-Pérez MM, Arce-Sánchez L, Martínez-Cruz N, Flores-Robles CM et al (2021) Prevalence of thyroid autoimmunity in women with recurrent pregnancy loss. Medicina (Kaunas) 57(2):96. https://doi.org/10.3390/medicina57020096

Article  PubMed  Google Scholar 

van den Boogaard E, Vissenberg R, Land JA, van Wely M, van der Post JAM, Goddijn M, Bisschop PH (2011) Significance of (sub)clinical thyroid dysfunction and thyroid autoimmunity before conception and in early pregnancy: a systematic review. Hum Reprod Update 17(5):605–19. https://doi.org/10.1093/humupd/dmr024

Article  PubMed  Google Scholar 

Zhong Y, Ying Y, Wu H, Zhou C, Xu Y, Wang Q et al (2012) Relationship between antithyroid antibody and pregnancy outcome following in vitro fertilization and embryo transfer. Int J Med Sci 9(2):121–125. https://doi.org/10.7150/ijms.3467

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abbassi-Ghanavati M, Casey BM, Spong CY, McIntire DD, Halvorson LM, Cunningham G et al (2010) Pregnancy outcomes in women with thyroid peroxidase antibodies. Obstet Gynecol 116(2):381–386. https://doi.org/10.1097/AOG.0b013e3181e904e5

Article  PubMed  Google Scholar 

Meena A, Nagar P (2016) Pregnancy outcome in euthyroid women with anti-thyroid peroxidase antibodies. J Obstet Gynaecol India 66(3):160–165. https://doi.org/10.1007/s13224-014-0657-6

Article  CAS  PubMed  Google Scholar 

Twig G, Shina A, Amital H, Shoenfeld Y (2012) Pathogenesis of infertility and recurrent pregnancy loss in thyroid autoimmunity. J Autoimmun 38(2–3):J275–J281. https://doi.org/10.1016/j.jaut.2011.11.014

Article  CAS  PubMed  Google Scholar 

Yamamoto J, Benham J, Nerenberg K, Donovan L (2018) Impact of levothyroxine therapy on obstetric, neonatal and childhood outcomes in women with subclinical hypothyroidism diagnosed in pregnancy; a systematic review and meta-analysis of randomized controlled trials. BMJ Open 18:1–10. https://doi.org/10.1136/bmjopen-2018-022837 [PMC free article] [PubMed] [CrossRef] [Google Scholar] [Ref list]

Article  Google Scholar 

Negro R, Formoso G, Mangieri T, Pezzarossa A, Dazzi D, Hassan H et al (2006) Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. J Clin Endocrinol Metab 91(7):2587–2591. https://doi.org/10.1210/jc.2005-1603

Article  CAS  PubMed  Google Scholar 

Kiran Z, Sheikh A, Malik S, Meraj A, Masood M, Ismail S et al (2019) Maternal characteristics and outcomes affected by hypothyroidism during pregnancy (maternal hypothyroidism on pregnancy outcomes, MHPO-1). BMV. 19:2596–2599. https://doi.org/10.1186/s12884-019-2596-9 [PMC free article] [PubMed] [CrossRef] [Google Scholar] [Ref list]

Article  CAS  Google Scholar 

Di Renzo GC (2019) Good clinical practice advice: thyroid and pregnancy. Int J Gynecol Obs 144:347–351 [Google Scholar] [Ref list]

Article  Google Scholar 

Practice Committee of American Society for Reproductive Medicine (2013) Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril.,2012 99(1):63. https://doi.org/10.1016/j.fertnstert.2012.09.023

Article  Google Scholar 

Kwak-Kim J, Yang KM, Gilman-Sachs A (2009) Recurrent pregnancy loss: a disease of inflammation and coagulation. J Obs Gynaecol Res 35:609–622. https://doi.org/10.1111/j.1447-0756.2009.01079.x [PubMed] [CrossRef] [Google Scholar] [Ref list]

Article  CAS  Google Scholar 

Jaslow CR, Carney JL, Kutteh WH (2010) Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses. Fertil. Steril. 93:1234–1243. https://doi.org/10.1016/j.fertnstert.2009.01.166 [PubMed] [CrossRef] [Google Scholar] [Ref list]

Article  CAS  PubMed  Google Scholar 

Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C et al (2017) 2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid 27(3):315–389

Article  PubMed  Google Scholar 

Chen L, Hu R (2011) Thyroid autoimmunity and miscarriage: a meta-analysis. Clin. Endocrinol 74:513–519. https://doi.org/10.1111/j.1365-2265.2010.03974.x [PubMed] [CrossRef] [Google Scholar] [Ref list]

Article  Google Scholar 

Dhillon-Smith RK, Tobias A, Smith PP, Middleton LJ, Sunner KK, Baker K et al (2020) The prevalence of thyroid dysfunction and autoimmunity in women with history of miscarriage or subfertility. J Clin Endocrinol Metab 105(8):dgaa302. https://doi.org/10.1210/clinem/dgaa302

Article  PubMed  Google Scholar 

Bliddal S, Derakhshan A, Xiao Y, Chen LM, Männistö T, Ashoor G et al (2022 Jul) (2022). Association of thyroid peroxidase antibodies and thyroglobulin antibodies with thyroid function in pregnancy: an individual participant data meta-analysis. Thyroid 32(7):828–840

Article  CAS  PubMed  Google Scholar 

Lata K, Dutta P, Sridhar S, Rohilla M, Srinivasan A, Prashad G et al (2013) Thyroid autoimmunity and obstetric outcomes in women with recurrent miscarriage: a case–control study. Endocr Connect 2(2):118–124. https://doi.org/10.1530/ec-13-0012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmad S, Geraci SA, Koch CA (2013) Thyroid disease in pregnancy: (Women's Health Series). South Med J 106(9):532–538

Article  CAS  PubMed  Google Scholar 

Abalovich M, Amino N, Barbour LA, Cobin RH, De Groot LJ, Glinoer D et al (2007) Management of thyroid dysfunction during pregnancy and postpartum: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 92:S1–S7. https://doi.org/10.1210/jc.2007-0141 [PubMed] [CrossRef] [Google Scholar] [Ref list]

Article  CAS  PubMed  Google Scholar 

Saki F, Dabbaghmanesh MH, Ghaemi SZ, Forouhari S, Omrani GR, Bakhshayeshkaram M (2015) Thyroid autoimmunity in pregnancy and its influences on maternal and fetal outcome in. Iran (a prospective study) Endocr Res 40(3):139–145. https://doi.org/10.3109/07435800.2014.966384

Article  CAS  PubMed  Google Scholar 

Prummel MF, Wiersinga WM (2004) Thyroid autoimmunity and miscarriage. Eur J Endocrinol 150:751–755. https://doi.org/10.1530/eje.0.1500751 [PubMed] [CrossRef] [Google Scholar]

Article  CAS  PubMed  Google Scholar 

Osinga JAJ, Derakhshan A, Palomaki GE, Ashoor G, Männistö T, Maraka S et al (2022 Sep 28) (2022). TSH and FT4 reference intervals in pregnancy: a systematic review and individual participant data meta-analysis. J Clin Endocrinol Metab. 107(10):2925–2933

Article  PubMed  PubMed Central  Google Scholar 

Dong AC, Morgan J, Kane M, Stagnaro-Green A, Stephenson MD (2020) Subclinical hypothyroidism and thyroid autoimmunity in recurrent pregnancy loss: a systematic review and meta-analysis. Fertil. Steril 113:587–600. https://doi.org/10.1016/j.fertnstert.2019.11.003 [PubMed] [CrossRef] [Google Scholar] [Ref list]

Article  CAS  PubMed  Google Scholar 

Plowden TC, Schisterman EF, Sjaarda LA, Zarek SM, Perkins NJ, Silver R et al (2016) Subclinical hypothyroidism and thyroid autoimmunity are not associated with fecundity, pregnancy loss, or live birth. J Clin Endocrinol Metab 101(6):2358–2365

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sitoris G, Veltri F, Kleynen P, Cogan A, Belhomme J, Rozenberg S et al (2019) The impact of thyroid disorders on clinical pregnancy outcomes in a real-world study setting. Thyroid. 30(1):106–115

Article  Google Scholar 

Rao M, Zeng Z, Zhou F, Wang H, Liu J, Wang R et al (2019) Effect of levothyroxine supplementation on pregnancy loss and preterm birth in women with subclinical hypothyroidism and thyroid autoimmunity: a systematic review and meta-analysis Hum Reprod Update. 25(3):344–361. https://doi.org/10.1093/humupd/dmz003

Negro R (2021) Outcomes in pregnant patients with subclinical hypothyroidism and thyroid autoimmunity: a critical appraisal of recent randomized controlled trials Endocr Metab Immune Disord Drug Targets. 21(8):1387–1391. https://doi.org/10.2174/1871530320999201116200153

Liu H, Shan Z, Li C, Mao J, Xie X, Wang W et al (2014) Maternal subclinical hypothyroidism, thyroid autoimmunity, and the risk of miscarriage: a prospective cohort study. Thyroid 24(11):1642–1649. https://doi.org/10.1089/thy.2014.0029

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beneventi F, De Maggio I, Bellingeri C, Cavagnoli C, Spada C, Boschetti A et al (2022) Thyroid autoimmunity and adverse pregnancy outcomes: a prospective cohort study Endocrine. 76(1):198–207. https://doi.org/10.1007/s12020-021-02958-w

Yuan N, Sun J, Li Z, Chai S, Zhang X, Linong J (2020) Relationship between anti-thyroid peroxidase antibody positivity and pregnancy-related and fetal outcomes in Euthyroid women: a single-center cohort study BMC Pregnancy Childbirth. 20:491.Published online 2020 Aug 26. https://doi.org/10.1186/s12884-020-03176-4

Negro R, Schwartz A, Gismondi R, Tinelli A, Mangieri T, Stagnaro-Green A et al (2011) Thyroid antibody positivity in the first trimester of pregnancy is associated with negative pregnancy outcomes. J Clin Endocrinol Metab 96(6):E920–E924. https://doi.org/10.1210/jc.2011-0026

Article  CAS  PubMed  Google Scholar 

Chen LM, Zhang Q, Si GX, Chen QS, Ye E-l, Yu L-C et al (2015) Associations between thyroid autoantibody status and abnormal pregnancy outcomes in euthyroid women. Endocrine 48(3):924–928

Article  CAS  PubMed  Google Scholar 

Rajput R, Yadav T, Seth S, Nanda S (2017) Prevalence of thyroid peroxidase antibody and pregnancy outcome in euthyroid autoimmune positive pregnant women from a tertiary care center in Haryana. Indian J Endocrinol Metab 21(4):577. https://doi.org/10.4103/ijem.IJEM_397_16

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stricker R, Echenard M, Eberhart R, Chevailler MC, Perez V, Quinn FA et al (2007) Evaluation of maternal thyroid function during pregnancy: the importance of using gestational age-specific reference intervals. Eur J Endocrinol 157(4):509–514. https://doi.org/10.1530/EJE-07-0249

Article  CAS  PubMed  Google Scholar 

Zhou M, Wang M, Juming L, Xiaohui L, Minxianf L (2019) Effects of thyroid diseases on pregnancy outcomes. Exp Ther Med 18:1807–1815. https://doi.org/10.3892/etm.2019.7739 [PMC free article] [PubMed] [CrossRef] [Google Scholar] [Ref list]

Article 

Comments (0)

No login
gif