Superior sagittal sinus thrombosis in the course of mixed phenotype acute leukaemia treated with acute lymphoblastic leukaemia-like therapy—a case report

Weinberg OK, Arber DA. Mixed-phenotype acute Leukemia: historical overview and a new definition. Leukemia. 2010;24(11):1844–51.

Article  CAS  PubMed  Google Scholar 

Khan M, Siddiqi R, Naqvi K. An update on classification, genetics, and clinical approach to mixed phenotype acute Leukemia (MPAL). Ann Hematol. 2018;97(6):945–53.

Article  CAS  PubMed  Google Scholar 

Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: myeloid and Histiocytic/Dendritic Neoplasms. Leukemia. 2022;36(7):1703–19.

Article  PubMed  PubMed Central  Google Scholar 

George BS, Yohannan B, Gonzalez A, Rios A. Mixed-phenotype Acute Leukemia: clinical diagnosis and therapeutic strategies. Biomedicines. 2022;10(8):1974.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mi X, Griffin G, Lee W, Patel S, Ohgami R, Ok CY, et al. Genomic and clinical characterization of B/T mixed phenotype acute Leukemia reveals recurrent features and T-ALL like mutations. Am J Hematol. 2018;93(11):1358–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bene MC, Castoldi G, Knapp W, Ludwig WD, Matutes E, Orfao A, et al. Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia. 1995;9(10):1783–6.

CAS  PubMed  Google Scholar 

Lazzarotto D, Tanasi I, Vitale A, Piccini M, Dargenio M, Giglio F, et al. Multicenter retrospective analysis of clinical outcome of adult patients with mixed-phenotype acute Leukemia treated with acute myeloid leukemia-like or acute lymphoblastic leukemia-like chemotherapy and impact of allogeneic stem cell transplantation: a campus ALL study. Ann Hematol. 2023;102(5):1099–109.

Article  CAS  PubMed  Google Scholar 

Maruffi M, Sposto R, Oberley MJ, Kysh L, Orgel E. Therapy for children and adults with mixed phenotype acute Leukemia: a systematic review and meta-analysis. Leukemia. 2018;32(7):1515–28.

Article  PubMed  PubMed Central  Google Scholar 

Polska Grupa ds. Leczenia Białaczek u Dorosłych. Protokół leczenia ostrej białaczki limfoblastycznej u dorosłych. Polish Adult Leukemia Group (PALG) guidelines for the treatment of ALL. [Internet]. 2022 [cited 2023 Jul 16]. Available from: www.palg.pl.

Rasekh EO, Osman R, Ibraheem D, Madney Y, Radwan E, Gameel A, et al. Acute lymphoblastic leukemia-like treatment regimen provides better response in mixed phenotype acute Leukemia: a comparative study between adults and pediatric MPAL patients. Ann Hematol. 2021;100(3):699–707.

Article  CAS  PubMed  Google Scholar 

Silverman LB, Supko JG, Stevenson KE, Woodward C, Vrooman LM, Neuberg DS, et al. Intravenous PEG-asparaginase during remission induction in children and adolescents with newly diagnosed acute lymphoblastic Leukemia. Blood. 2010;115(7):1351–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Béné MC, Porwit A. Mixed Phenotype/Lineage Leukemia: has anything changed for 2021 on diagnosis, classification, and treatment? Curr Oncol Rep. 2022;24(8):1015–22.

Article  PubMed  PubMed Central  Google Scholar 

Hongo T, Okada S, Ohzeki T, Ohta H, Nishimura SI, Hamamoto K, et al. Low plasma levels of hemostatic proteins during the induction phase in children with acute lymphoblastic Leukemia: a retrospective study by the JACLS. Japan Association of Childhood Leukemia Study. Pediatr Int off J Jpn Pediatr Soc. 2002;44(3):293–9.

CAS  Google Scholar 

Stock W, Douer D, DeAngelo DJ, Arellano M, Advani A, Damon L, et al. Prevention and management of asparaginase/pegasparaginase-associated toxicities in adults and older adolescents: recommendations of an expert panel. Leuk Lymphoma. 2011;52(12):2237–53.

Article  CAS  PubMed  Google Scholar 

Riley DO, Schlefman JM, Vitzthum Von Eckstaedt VHC, Morris AL, Keng MK, El Chaer F. Pegaspargase in practice: minimizing toxicity, Maximizing Benefit. Curr Hematol Malig Rep. 2021;16(3):314–24.

Article  PubMed  Google Scholar 

Grace RF, Dahlberg SE, Neuberg D, Sallan SE, Connors JM, Neufeld EJ, et al. The frequency and management of asparaginase-related Thrombosis in paediatric and adult patients with acute lymphoblastic Leukaemia treated on Dana-Farber Cancer Institute consortium protocols. Br J Haematol. 2011;152(4):452–9.

Article  PubMed  PubMed Central  Google Scholar 

Payne JH, Vora AJ. Thrombosis and acute lymphoblastic Leukaemia. Br J Haematol. 2007;138(4):430–45.

Article  PubMed  Google Scholar 

De Stefano V, Sorà F, Rossi E, Chiusolo P, Laurenti L, Fianchi L, et al. The risk of Thrombosis in patients with acute Leukemia: occurrence of Thrombosis at diagnosis and during treatment. J Thromb Haemost JTH. 2005;3(9):1985–92.

Article  PubMed  Google Scholar 

Ziegler S, Sperr WR, Knöbl P, Lehr S, Weltermann A, Jäger U, et al. Symptomatic venous thromboembolism in acute Leukemia. Incidence, risk factors, and impact on prognosis. Thromb Res. 2005;115(1–2):59–64.

Article  CAS  PubMed  Google Scholar 

Hunault-Berger M, Chevallier P, Delain M, Bulabois CE, Bologna S, Bernard M, et al. Changes in antithrombin and fibrinogen levels during induction chemotherapy with L-asparaginase in adult patients with acute lymphoblastic Leukemia or lymphoblastic Lymphoma. Use of supportive coagulation therapy and clinical outcome: the CAPELAL study. Haematologica. 2008;93(10):1488–94.

Article  CAS  PubMed  Google Scholar 

Chen R, Atenafu EG, Seki J, Liu X, Chan S, Gupta V, et al. Venous thromboembolism incidence associated with pegylated asparaginase (ASP) compared to the native L-ASP: a retrospective analysis with an ASP-based protocol in adult patients with acute lymphoblastic Leukaemia. Br J Haematol. 2023;201(4):645–52.

Article  CAS  PubMed  Google Scholar 

Hoelzer D, Bassan R, Dombret H, Fielding A, Ribera JM, Buske C, et al. Acute lymphoblastic Leukaemia in adult patients: ESMO Clinical Practice guidelines for diagnosis, treatment and follow-up. Ann Oncol off J Eur Soc Med Oncol. 2016;27(suppl 5):v69–82.

Article  CAS  Google Scholar 

Underwood B, Zhao Q, Walker AR, Mims AS, Vasu S, Long M, et al. Incidence of venous Thrombosis after peg-asparaginase in adolescent and young adults with acute lymphoblastic Leukemia. Int J Hematol Oncol. 2020;9(3):IJH28.

CAS  PubMed  PubMed Central  Google Scholar 

Elliott MA, Wolf RC, Hook CC, Pruthi RK, Heit JA, Letendre LL, et al. Thromboembolism in adults with acute lymphoblastic Leukemia during induction with L-asparaginase-containing multi-agent regimens: incidence, risk factors, and possible role of antithrombin. Leuk Lymphoma. 2004;45(8):1545–9.

Article  PubMed  Google Scholar 

Gugliotta L, Mazzucconi MG, Leone G, Mattioli-Belmonte M, Defazio D, Annino L, et al. Incidence of thrombotic Complications in adult patients with acute lymphoblastic Leukaemia receiving L-asparaginase during induction therapy: a retrospective study. The GIMEMA Group. Eur J Haematol. 1992;49(2):63–6.

Article  CAS  PubMed  Google Scholar 

Aldoss I, Douer D, Behrendt CE, Chaudhary P, Mohrbacher A, Vrona J, et al. Toxicity profile of repeated doses of PEG-asparaginase incorporated into a pediatric-type regimen for adult acute lymphoblastic Leukemia. Eur J Haematol. 2016;96(4):375–80.

Article  CAS  PubMed  Google Scholar 

Tuckuviene R, Bjerg CL, Jonsson OG, Langstrom S, Rank CU, Ranta S, et al. Pulmonary Embolism in acute lymphoblastic Leukemia — an observational study of 1685 patients treated according to the NOPHO ALL2008 protocol. Res Pract Thromb Haemost. 2020;4(5):866–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuhle S, Spavor M, Massicotte P, Halton J, Cherrick I, Dix D, et al. Prevalence of post-thrombotic syndrome following asymptomatic Thrombosis in survivors of acute lymphoblastic Leukemia. J Thromb Haemost. 2008;6(4):589–94.

Article  CAS  PubMed  Google Scholar 

Silvis SM, de Sousa DA, Ferro JM, Coutinho JM. Cerebral venous Thrombosis. Nat Rev Neurol. 2017;13(9):555–65.

Article  PubMed  Google Scholar 

Kristoffersen ES, Harper CE, Vetvik KG, Zarnovicky S, Hansen JM, Faiz KW. Incidence and mortality of cerebral venous Thrombosis in a Norwegian Population. Stroke. 2020;51(10):3023–9.

Article  PubMed  Google Scholar 

Couturier MA, Huguet F, Chevallier P, Suarez F, Thomas X, Escoffre-Barbe M, et al. Cerebral venous Thrombosis in adult patients with acute lymphoblastic Leukemia or lymphoblastic Lymphoma during induction chemotherapy with l-asparaginase: the GRAALL experience. Am J Hematol. 2015;90(11):986–91.

Article  CAS  PubMed  Google Scholar 

Dentali F, Gianni M, Crowther MA, Ageno W. Natural history of cerebral vein Thrombosis: a systematic review. Blood. 2006;108(4):1129–34.

Article  CAS  PubMed  Google Scholar 

Coutinho JM, Zuurbier SM, Stam J. Declining mortality in cerebral venous Thrombosis: a systematic review. Stroke. 2014;45(5):1338–41.

Article  PubMed  Google Scholar 

Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F, Investigators ISCVT. Prognosis of cerebral vein and dural sinus Thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke. 2004;35(3):664–70.

Article  PubMed  Google Scholar 

Zuurbier SM, Lauw MN, Coutinho JM, Majoie CBLM, van der Holt B, Cornelissen JJ, et al. Clinical course of cerebral venous Thrombosis in adult Acute Lymphoblastic Leukemia. J Stroke Cerebrovasc Dis off J Natl Stroke Assoc. 2015;24(7):1679–84.

Article  Google Scholar 

Wani NA, Kosar T, Pala NA, Qureshi UA. Sagittal sinus Thrombosis due to L-asparaginase. J Pediatr Neurosci. 2010;5(1):32–5.

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