aan het Rot M, Mathew SJ, Charney DS (2009) Neurobiological mechanisms in major depressive disorder. CMAJ 180:305–313
Article PubMed PubMed Central Google Scholar
Adrian M, Kiff C, Glazner C, Kohen R, Tracy JH, Zhou C, Vander Stoep A (2015) Examining gene-environment interactions in comorbid depressive and disruptive behavior disorders using a Bayesian approach. J Psychiatr Res 68:125–133
Article PubMed PubMed Central Google Scholar
Aleem S, Huda N, Amin R, Khalid S, Alshamrani SS, Alshehri A (2022) Machine learning algorithms for depression: diagnosis, insights, and research directions. Electronics 11(7):1111. https://doi.org/10.3390/electronics11071111
Bell AF, Carter CS, Steer CD et al (2015) Interaction between oxytocin receptor DNA methylation and genotype is associated with risk of postpartum depression in women without depression in pregnancy. Front Genet 6:243. https://doi.org/10.3389/fgene.2015.00243
Article CAS PubMed PubMed Central Google Scholar
Burmester V, Nicholls D, Buckle A, Stanojevic B, Crous-Bou M (2021) Review of eating disorders and oxytocin receptor polymorphisms. J Eat Disord 9(1):85. https://doi.org/10.1186/s40337-021-00438-0
Article PubMed PubMed Central Google Scholar
Butovskaya M, Rostovtseva V, Butovskaya P, Burkova V, Dronova D, Filatova V, Sukhodolskaya E, Vasiliev V, Mesa T, Rosa A, Lazebny O (2020) Oxytocin receptor gene polymorphism (rs53576) and digit ratio associates with aggression: comparison in seven ethnic groups. J Physiol Anthropol 39(1):20. https://doi.org/10.1186/s40101-020-00232-y
Article PubMed PubMed Central Google Scholar
Chagnon YC, Potvin O, Hudon C, Préville M (2015) DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women. Front Genet 6:230. https://doi.org/10.3389/fgene.2015.00230
Article CAS PubMed PubMed Central Google Scholar
Chang WH, Lee IH, Chen KC, Chi MH, Chiu NT, Yao WJ, Lu RB, Yang YK, Chen PS (2014) Oxytocin receptor gene rs53576 polymorphism modulates oxytocin-dopamine interaction and neuroticism traits–a SPECT study. Psychoneuroendocrinology 47:212–220. https://doi.org/10.1016/j.psyneuen.2014.05.020
Article CAS PubMed Google Scholar
Cicchetti D, Rogosch FA, Hecht KF, Crick NR, Hetzel S (2014) Moderation of maltreatment effects on childhood borderline personality symptoms by gender and oxytocin receptor and FK506 binding protein 5 genes. Dev Psychopathol 26(3):831–849
Article PubMed PubMed Central Google Scholar
Cleveland HH, Griffin AM, Wolf PSA, Wiebe RP, Schlomer GL, Feinberg ME, Vandenbergh DJ (2018) Transactions between substance use intervention, the oxytocin receptor (OXTR) gene, and peer substance use predicting youth alcohol use. Prev Sci 19(1):15–26
Article PubMed PubMed Central Google Scholar
Costa B, Pini S, Baldwin DS et al (2017) Oxytocin receptor and G-protein polymorphisms in patients with depression and separation anxiety. J Affect Disord 218:365–373. https://doi.org/10.1016/j.jad.2017.03.056
Article CAS PubMed Google Scholar
Costa B, Pini S, Gabelloni P et al (2009) Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology 34(10):1506–1514. https://doi.org/10.1016/j.psyneuen.2009.05.006
Article CAS PubMed Google Scholar
Dumais KM, Veenema AH (2015) Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior. Front Neuroendocrinol. https://doi.org/10.1016/j.yfrne.2015.04.003
Article PubMed PubMed Central Google Scholar
Gong P, Fan H, Liu J, Yang X, Zhang K, Zhou X (2017) Revisiting the impact of OXTR rs53576 on empathy: a population-based study and a meta-analysis. Psychoneuroendocrinology 80:131–136. https://doi.org/10.1016/j.psyneuen.2017.03.005
Article CAS PubMed Google Scholar
Grippo AJ, Gerena D, Huang J, Kumar N, Shah M, Ughreja R, Carter CS (2007) Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles. Psychoneuroendocrinology 32:966–980
Article CAS PubMed PubMed Central Google Scholar
He J, Buil JM, Koot HM, van Lier PAC (2018) Associations between Oxytocin receptor (OXTR) genotype and elementary school children’s likability, dis-likability and friendship among classroom peers: a longitudinal study. J Youth Adolesc 47(9):1799–1812
Article PubMed PubMed Central Google Scholar
Hong EP, Park JW (2012) Sample size and statistical power calculation in genetic association studies. Genomics Inform 10:117–122
Article PubMed PubMed Central Google Scholar
Hovey D, Lindstedt M, Zettergren A, Jonsson L, Johansson A, Melke J, Westberg L (2016) Antisocial behavior and polymorphisms in the oxytocin receptor gene: findings in two independent samples. Mol Psychiatry 21(7):983–988
Article CAS PubMed Google Scholar
Inoue T, Kimura T, Azuma C, Inazawa J, Takemura M, Kikuchi T et al (1994) Structural organization of the human oxytocin receptor gene. J Biol Chem 269:32451–32456
Article CAS PubMed Google Scholar
Kantor BN, Kantor J (2020) Mental health outcomes and associations during the COVID-19 pandemic: a cross-sectional population-based study in the United States. Front Psychiatry 11:569083. https://doi.org/10.3389/fpsyt.2020.569083
Article PubMed PubMed Central Google Scholar
Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H (1992) Structure and expression of a human oxytocin receptor. Nature 356(6369):526–529
Article CAS PubMed Google Scholar
Kohlhoff J, Cibralic S, Hawes DJ, Eapen V (2022) Oxytocin receptor gene (OXTR) polymorphisms and social, emotional and behavioral functioning in children and adolescents: a systematic narrative review. Neurosci Biobehav Rev 135:104573. https://doi.org/10.1016/j.neubiorev.2022.104573
Article CAS PubMed Google Scholar
Lee KW, Ching SM, Ramachandran V et al (2019) Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus. Genes (Basel) 10(12):988. https://doi.org/10.3390/genes10120988
Article CAS PubMed PubMed Central Google Scholar
Li J, Zhao Y, Li R, Broster LS, Zhou C, Yang S (2015) Association of oxytocin receptor gene (OXTR) rs53576 polymorphism with sociality: a meta-analysis. PLoS ONE 10(6):e0131820. https://doi.org/10.1371/journal.pone.0131820
Article CAS PubMed PubMed Central Google Scholar
Liu CH, Zhang E, Wong GTF, Hyun S, Hahm HC (2020) Factors associated with depression, anxiety, and PTSD symptomatology during the COVID-19 pandemic: clinical implications for U.S. young adult mental health. Psychiatry Res 290:113172. https://doi.org/10.1016/j.psychres.2020.113172
Article CAS PubMed PubMed Central Google Scholar
Martinowich K, Schloesser RJ, Manji HK (2009) Bipolar disorder: from genes to behavior pathways. J Clin Invest 119:726–736
Article CAS PubMed PubMed Central Google Scholar
Mazza MG, Palladini M, Poletti S et al (2022) Post-COVID-19 depressive symptoms: epidemiology, pathophysiology, and pharmacological treatment. CNS Drugs 36:681–702. https://doi.org/10.1007/s40263-022-00931-3
Article CAS PubMed PubMed Central Google Scholar
Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7):e1000097. https://doi.org/10.1371/journal.pmed.1000097
Article PubMed PubMed Central Google Scholar
Na KS, Won E, Kang J et al (2018) Interaction effects of oxytocin receptor gene polymorphism and depression on hippocampal volume. Psychiatry Res Neuroimaging 282:18–23. https://doi.org/10.1016/j.pscychresns.2018.10.004
Park J, Willmott M, Vetuz G, Toye C, Kirley A, Hawi Z, Kent L (2010) Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD. Prog NeuroPsychopharmacol Biol Psychiatry 34(4):697–702
Article CAS PubMed Google Scholar
Poore HE, Waldman ID (2020) The association of oxytocin receptor gene (OXTR) polymorphisms with antisocial behavior: a meta-analysis. Behav Genet 50(3):161–173. https://doi.org/10.1007/s10519-020-09996-6
Saphire-Bernstein S, Way BM, Kim HS, Sherman DK, Taylor SE (2011) Oxytocin receptor gene (OXTR) is related to psychological resources. Proc Natl Acad Sci U S A 108(37):15118–15122. https://doi.org/10.1073/pnas.1113137108
Article PubMed PubMed Central Google Scholar
Smarius LJCA, Strieder TGA, Doreleijers TAH, Vrijkotte TGM, Zafarmand MH, de Rooij SR (2019) Common oxytocin polymorphisms interact with maternal verbal aggression in early infancy impacting blood pressure at age 5–6: the ABCD study. PLoS One 14(6):e0216035. https://doi.org/10.1371/journal.pone.0216035
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