HMG-CoA reductase inhibitors and the attenuation of risk for disseminated intravascular coagulation in patients with sepsis

Gando S, Shiraishi A, Yamakawa K et al (2019) Japanese Association for Acute Medicine [JAAM) focused Outcomes Research in Emergency Care in Acute Respiratory Distress Syndrome, Sepsis and Trauma (FORECAST) Study Group. Role of disseminated intravascular coagulation in severe sepsis. Thromb Res 178:182–188. https://doi.org/10.1016/j.thromres.2019.04.025

Article  CAS  PubMed  Google Scholar 

Levi M, Scully M (2018) How I treat disseminated intravascular coagulation. Blood 131:845–854. https://doi.org/10.1182/blood-2017-10-804096

Article  CAS  PubMed  Google Scholar 

Iba T, Watanabe E, Umemura Y, Wada T, Hayashida K, Kushimoto S (2019) Japanese surviving Sepsis Campaign Guideline Working Group for disseminated intravascular coagulation. Sepsis-associated disseminated intravascular coagulation and its differential diagnoses. J Intensive Care 7:32. https://doi.org/10.1002/ams2.411

Article  PubMed  PubMed Central  Google Scholar 

Okamoto K, Tamura T, Sawatsubashi Y (2016) Sepsis and disseminated intravascular coagulation. J Intensive Care 23:4–23. https://doi.org/10.1186/s40560-016-0149-0

Article  Google Scholar 

Cohen J (2002) The immunopathogenesis of sepsis. Nature. https://doi.org/10.1038/nature01326. 420:885 – 91

Article  PubMed  PubMed Central  Google Scholar 

Liao JK, Laufs U (2005) Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol 45:89–118. https://doi.org/10.1146/annurev.pharmtox.45.120403.095748

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diamantis E, Kyriakos G, Quiles-Sanchez LV, Farmaki P, Troupis T (2017) The anti-inflammatory effects of statins on Coronary Artery Disease: an updated review of the literature. Curr Cardiol Rev 13:209–216. https://doi.org/10.2174/1573403X13666170426104611

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bakhtiari K, Meijers JC, de Jonge E, Levi M (2004) Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med 32:2416–2421. https://doi.org/10.1097/01.ccm.0000147769.07699.e3

Article  PubMed  Google Scholar 

Singer M, Deutschman CS, Seymour CW et al (2016) The Third International Consensus definitions for Sepsis and septic shock (Sepsis-3). JAMA 315:801. https://doi.org/10.1001/jama.2016.0287

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sidebottom AC, Vacquier MC, Jensen JC et al (2020) Trends in prevalence of guideline-based use of lipid-lowering therapy in a large health system. Clin Cardiol 43(6):560–567. https://doi.org/10.1002/clc.23347

Article  PubMed  PubMed Central  Google Scholar 

Roy AM, Konda M, Goel A, Sasapu A (2019) Epidemiology and factors affecting mortality of hospitalized patients with disseminated intravascular coagulation in the United States. Blood 134:2404. https://doi.org/10.1182/blood-2019-132071

Article  Google Scholar 

Falanga A, Marchetti M, Vignoli A (2013) Coagulation and cancer: biological and clinical aspects. J Thromb Haemost 11:223–233. https://doi.org/10.1111/jth.12075

Article  CAS  PubMed  Google Scholar 

Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, Rubenfeld G, Kahn JM, Shankar-Hari M, Singer M, Deutschman CS, Escobar GJ, Angus DC (2013) Assessment of Clinical Criteria for Sepsis: for the Third International Consensus definitions for Sepsis and septic shock (Sepsis-3). JAMA 315:762–774. https://doi.org/10.1001/jama.2016.0288

Article  CAS  Google Scholar 

Yamazaki M, Aoshima K, Mizutani T, Ontachi Y, Saito M, Morishita E, Asakura H, Matsuda T, Triplett DA (1999) Prednisolone inhibits endotoxin-induced disseminated intravascular coagulation and improves mortality in rats: importance of inflammatory cytokine suppression. Blood Coagul Fibrinolysis 10:321–330. https://doi.org/10.1097/00001721-199909000-00002

Article  CAS  PubMed  Google Scholar 

Liu XL, Wang XZ, Liu XX, Hao D, Jaladat Y, Lu F, Sun T, Lv CJ (2014) Low-dose heparin as treatment for early disseminated intravascular coagulation during sepsis: a prospective clinical study. Exp Ther Med 7:604–608. https://doi.org/10.3892/etm.2013.1466

Article  CAS  PubMed  Google Scholar 

Sakuragawa N, Hasegawa H, Maki M, Nakagawa M, Nakashima M (1993) Clinical evaluation of low-molecular-weight heparin (FR-860) on disseminated intravascular coagulation (DIC)--a multicenter co-operative double-blind trial in comparison with heparin. Thromb Res 72:475–500. https://doi.org/10.1016/0049-3848(93)90109-2

Article  CAS  PubMed  Google Scholar 

Papageorgiou C, Jourdi G, Adjambri E, Walborn A, Patel P, Fareed J, Elalamy I, Hoppensteadt D, Gerotziafas GT (2018) Disseminated intravascular coagulation: an update on Pathogenesis, diagnosis, and therapeutic strategies. Clin Appl Thromb Hemost 24:8S28S. https://doi.org/10.1177/1076029618806424

Article  CAS  Google Scholar 

Jain MK, Ridker PM (2005) Anti-inflammatory effects of statins: clinical evidence and basic mechanisms. Nat Rev Drug Discov. https://doi.org/10.1038/nrd1901. 4:977 – 87

Article  PubMed  Google Scholar 

Undas A, Brummel-Ziedins KE, Mann KG (2005) Statins and blood coagulation. Arterioscler Thromb Vasc Biol. https://doi.org/10.1161/01.ATV.0000151647.14923.ec. 25:287 – 94

Article  PubMed  PubMed Central  Google Scholar 

Greenwood J, Mason JC (2007) Statins and the vascular endothelial inflammatory response. Trends Immunol 28:88–98. https://doi.org/10.1016/j.it.2006.12.003

Article  CAS  PubMed  Google Scholar 

Badimon L, Vilahur G (2014) Thrombosis formation on atherosclerotic lesions and plaque rupture. J Intern Med 276:618–632. https://doi.org/10.1111/joim.12296

Article  CAS  PubMed  Google Scholar 

Diomede L, Albani D, Sottocorno M, Donati MB, Bianchi M, Fruscella P, Salmona M (2001) In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products. Arterioscler Thromb Vasc Biol 21:1327–1332. https://doi.org/10.1161/hq0801.094222

Article  CAS  PubMed  Google Scholar 

Sukhova GK, Williams JK, Libby P (2002) Statins reduce inflammation in atheroma of nonhuman primates Independent of effects on serum cholesterol. Arterioscler Thromb Vasc Biol 22:1452–1458. https://doi.org/10.1161/01.atv.0000030360.72503.56

Article  CAS  PubMed  Google Scholar 

Monetti M, Canavesi M, Camera M, Parente R, Paoletti R, Tremoli E, Corsini A, Bellosta S (2007) Rosuvastatin displays anti-atherothrombotic and anti-inflammatory properties in apoe-deficient mice. Pharmacol Res 55:441–449. https://doi.org/10.1016/j.phrs.2007.02.001

Article  CAS  PubMed  Google Scholar 

Yoshida M, Sawada T, Ishii H, Gerszten RE, Rosenzweig A, Gimbrone MA Jr, Yasukochi Y, Numano F (2001) Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of rho GTPase-dependent mechanism. Arterioscler Thromb Vasc Biol 21:1165–1171. https://doi.org/10.1161/hq0701.092143

Article  CAS  PubMed  Google Scholar 

Colli S, Eligini S, Lalli M, Camera M, Paoletti R, Tremoli E (1997) Vastatins inhibit tissue factor in cultured human macrophages. A novel mechanism of protection against atherothrombosis. Arterioscler Thromb Vasc Biol 17:265–272. https://doi.org/10.1161/01.atv.17.2.265

Article  CAS  PubMed  Google Scholar 

Baetta R, Camera M, Comparato C, Altana C, Ezekowitz MD, Tremoli E (2002) Fluvastatin reduces tissue factor expression and macrophage accumulation in carotid lesions of cholesterol-fed rabbits in the absence of lipid lowering. Arterioscler Thromb Vasc Biol 22:692–698. https://doi.org/10.1161/01.atv.0000012802.69414.a8

Article  CAS  PubMed  Google Scholar 

Lopez S, Peiretti F, Bonardo B, Deprez-Beauclair P, Laouenan H, Juhan-Vague I, Nalbone G (2001) Effect of atorvastatin on plasminogen activator inhibitor type-1 synthesis in human monocytes/macrophages. J Cardiovasc Pharmacol 37:762–768. https://doi.org/10.1097/00005344-200106000-00014

Article  CAS  PubMed  Google Scholar 

Bourcier T, Libby P (2000) HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells. Arterioscler Thromb Vasc Biol 20:556–562. https://doi.org/10.1161/01.atv.20.2.556

Article  CAS  PubMed  Google Scholar 

Guven GS, Atalar E, Yavuz B, Beyazit Y, Kekilli M, Kilicarslan A, Sahiner L, Oz G, Ozer N, Aksoyek S, Haznedaroglu IC, Sozen T (2006) Simvastatin treatment improves endothelial function and increases fibrinolysis in patients with hypercholestrolemia. J Natl Med Assoc 98:627–630

PubMed  PubMed Central  Google Scholar 

Bruni F, Pasqui AL, Pastorelli M, Bova G, Di Renzo M, Cercigani M, Leo A, Auteri A, Puccetti L (2004) Effect of atorvastatin on different fibrinolyis mechanisms in hypercholesterolemic subjects. Int J Cardiol 95:269–274. https://doi.org/10.1016/j.ijcard.2003.08.003

Article  CAS  PubMed  Google Scholar 

Shi J, Wang J, Zheng H, Ling W, Joseph J, Li D, Mehta JL, Ponnappan U, Lin P, Fink LM, Hauer-Jensen M (2003) Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract Tumor necrosis factor alpha-induced thrombomodulin downregulation. Blood Coagul Fibrinolysis 14:575–585. https://doi.org/10.1097/00001721-200309000-00010

Article  CAS  PubMed  Google Scholar 

Masamura K, Oida K, Kanehara H, Suzuki J, Horie S, Ishii H, Miyamori I (2003) Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the rho family. Arterio

留言 (0)

沒有登入
gif