Sniecinski RM, Levy JH (2011) Bleeding and management of coagulopathy. J Thorac Cardiovasc Surg 142:662–667. https://doi.org/10.1016/j.jtcvs.2011.03.015
Dai Z, Chu H, Wang S, Liang Y (2018) The effect of tranexamic acid to reduce blood loss and transfusion on off-pump coronary artery bypass surgery: a systematic review and cumulative meta-analysis. J Clin Anesth 44:23–31. https://doi.org/10.1016/j.jclinane.2017.10.004
Article CAS PubMed Google Scholar
Klein A, Agarwal S, Cholley B, Fassl J, Griffin M, Kaakinen T et al (2022) A review of European guidelines for patient blood management with a particular emphasis on antifibrinolytic drug administration for cardiac surgery. J Clin Anesth 78:110654. https://doi.org/10.1016/j.jclinane.2022.110654
Article CAS PubMed Google Scholar
Pasrija C, Ghoreishi M, Whitman G, Ad N, Alejo DE, Holmes SD et al (2019) Mitigating the risk: transfusion or reoperation for bleeding after cardiac surgery. Ann Thorac Surg 110:457–463. https://doi.org/10.1016/j.athoracsur.2019.10.076
Corredor C, Wasowicz M, Karkouti K, Sharma V (2015) The role of point-of-care platelet function testing in predicting postoperative bleeding following cardiac surgery: a systematic review and meta-analysis. Anaesthesia 70:715–731. https://doi.org/10.1111/anae.13083
Article CAS PubMed Google Scholar
Kestin AS, Valeri CR, Khuri SF, Loscalzo J, Ellis PA, MacGregor H et al (1993) The platelet function defect of cardiopulmonary bypass. Blood 82:107–117
Article CAS PubMed Google Scholar
Hamid M, Akhtar MI, Naqvi HI, Ahsan K (2017) Incidence and pattern of thrombocytopenia in cardiac surgery patients. Pak Med Assoc 67:1019–1023
Nazy I, Clare R, Staibano P, Warkentin TE, Larché M, Moore JC et al (2018) Cellular immune responses to platelet factor 4 and heparin complexes in patients with heparin-induced thrombocytopenia. J Thromb Haemost 16:1402–1412. https://doi.org/10.1111/jth.14132
Article CAS PubMed Google Scholar
Kumar PD (2007) Prevention and treatment of major blood loss. T N Engl J Med 357:1260–1261. https://doi.org/10.1111/jth.14132
Faught C, Wells P, Fergusson D, Laupacis A (1998) Adverse effects of methods for minimizing perioperative allogeneic transfusion: a critical review of the literature. Transfus Med Rev 12:206–225. https://doi.org/10.1016/s0887-7963(98)80061-8
Article CAS PubMed Google Scholar
Weber CF, Görlinger K, Byhahn C, Moritz A, Hanke AA, Zacharowski K et al (2011) Tranexamic acid partially improves platelet function in patients treated with dual antiplatelet therapy. Eur J Anaesthesiol 28:57–62. https://doi.org/10.1159/000505714
Mezzano D, Panes O, Muñoz B, Pais E, Tagle R, González F et al (1999) Tranexamic acid inhibits fibrinolysis, shortens the bleeding time and improves platelet function in patients with chronic renal failure. Thromb Haemost 82:1250–1254
Article CAS PubMed Google Scholar
Mengistu AM, Röhm KD, Boldt J, Mayer J, Suttner SW, Piper SN (2008) The influence of aprotinin and tranexamic acid on platelet function and postoperative blood loss in cardiac surgery. Anesth Analg 107:391–397. https://doi.org/10.1213/ane.0b013e31817b7732
Article CAS PubMed Google Scholar
Amara U, Rittirsch D, Flierl M, Bruckner U, Klos A, Gebhard F (2008) Interaction between the coagulation and complement system. Adv Exp Med Biol 632:71–79. https://doi.org/10.1007/978-0-387-78952-1_6
Article CAS PubMed PubMed Central Google Scholar
Mao Y, Jin J, Daniel JL, Kunapuli SP (2009) Regulation of plasmin-induced protease-activated receptor 4 activation in platelets. Platelets 20:191–198. https://doi.org/10.1080/09537100902803635
Article CAS PubMed Google Scholar
Blauhut B, Harringer W, Bettelheim P, Doran JE, Späth P, Lundsgaard-Hansen P (1994) Comparison of the effects of aprotinin and tranexamic acid on blood loss and related variables after cardiopulmonary bypass. J Thorac Cardiovasc Surg 108:1083–1091
Article CAS PubMed Google Scholar
Haley KM (2020) Platelet disorders. Pediatr Rev 41:224–235. https://doi.org/10.1542/pir.2018-0359
Lv H, Zhang Y, Zhao W, Lv HR, Zhou Y, Tian LJ, Shi J (2019) Effect of tranexamie acid on thromboxane B2 in patients receiving cardiac surgery with cardiopulmonarybypass. Natl Med J China 38:499–503. https://doi.org/10.3969/j.issn.1007-5062.2019.05.013
Xie XX (2019) Application of two different doses of tranexamic acid in cardiac surgery with cardiopulmonary bypass. CDDB, pp 3–10
Zhang L, Wang Y (2018) Effect of tranexamic acid on coagulation function and postoperative bleeding in cardiac surgery under extracorporeal circulation. Modern J Integrated Tradit China Western Med 27:559–561. https://doi.org/10.3969/j.issn.1008-8849.2018.05.032
Li HX (2018) Clinical observation of ulinastatin and tranexamic acid in cardiovascular anesthesia and extracorporeal circulation. J Clin Rational Drug Use 11:71–72
Xu GP, Li T (2018) Effect of tranexamic acid combined with ulinastatin on coagulation function in patients undergoing off-cardiopulmonary bypass grafting. China Med 13:1811–1814. https://doi.org/10.3760/j.issn.1673-4777.2018.12.012
Li Y, Zhang S, Zhou Y, Qi Y, Guo JR (2017) Tranexamic acid combined with acute isovolumic hemodilution in off-cardiopulmonary bypass grafting. Clin Pharmacol Therap China 22:584–588
Wang JX (2017) Blood protective effect of tranexamic acid on patients undergoing off-cardiopulmonary bypass coronary artery transplantation. China Med Clin 17:1360–1362. https://doi.org/10.11655/zgywylc2017.09.047
Yang JM (2017) Application of tranexamic acid in open heart valve replacement. China J Modern Surg 07:117–120. https://doi.org/10.16260/j.cnki.1009-2188.2017.02.010
Zhang ZB, Xi JF, Jiang ZX, Wei XQ (2016) Effects of tranexamic acid on blood loss, blood transfusion volume and complications in patients undergoing Sun’s surgery for acute Stanford Type A aortic dissection. J Clin Res 33:1249–1252. https://doi.org/10.3969/j.issn.1671-7171.2016.07.001
Shou XM, Yu LL (2016) Blood protective effect of tranexamic acid on adult congenital heart disease surgery. China J Clin Thorac Cardiovasc Surg 23:1139–1141. https://doi.org/10.7507/1007-4848.20160268
Liu YQ, Bao WJ, Jiang YN, Jiang YL (2015) Protective effect of tranexamic acid and ulinastatin on coagulation function in children with tetralogy of Fallot after cardiopulmonary bypass surgery. Shandong Med J 55:48–49. https://doi.org/10.3969/j.issn.1002-266X.2015.39.019
Guo T, Han Z, Xin YT (2015) Effect of tranexamic acid on off -pump coronary artery bypass grafting. J Aerospace Med 26:678–680. https://doi.org/10.3969/j.issn.2095-1434.2015.06.009
Zhang Y, Zhang WL, Mu CF (2014) Protective effect of tranexamic acid combined with ulinastatin on blood in patients undergoing cardiac valve replacement. J Hainan Medical College 20:1217–1222. https://doi.org/10.13210/j.cnki.jhmu.20140522.017
Qi J, Dai SB (2013) Blood-saving effect of different doses of tranexamic acid in patients undergoing cardiac valve replacement cardiopulmonary bypass. China J Anesthesiol 33:1195–1197. https://doi.org/10.3760/cma.j.issn.0254-1416.2013.10.010
Zhao P, Yang C, Wen DG, Meng CY, Luo B (2012) Clinical observation of tranexamic acid in reducing bleeding after extracorporeal circulation. J Clin Surg 20:495–497. https://doi.org/10.3969/j.issn.1005-6483.2012.07.021
Wang G, Xie G, Jiang T, Wang Y, Wang W, Ji H et al (2012) Tranexamic acid reduces blood loss after off-pump coronary surgery: a prospective, randomized, double-blind, placebo-controlled study. Anesth Analg 115:239–243. https://doi.org/10.1213/ANE.0b013e3182264a11
Article CAS PubMed Google Scholar
Pan X, Tang CZ, Sun WT, Xie SB, Li H, Zhao Z et al (2012) Application of tranexamic acid in cardiac valve replacement surgery. Beijing Medical 34:580–581
Tu J, Zhang BD, Lv J, Liang DK (2011) Blood conservative effects of tranexamic acid on children with cyanotic congenital heart disease. J Appl Clin Pediatr 26:1793–1795. https://doi.org/10.3969/j.issn.1003-515X.2011.23.011
Xiao JB, Wang WB, Zhou X, Wang SB, Fang C (2011) Application of tranexamic acid in anesthesia for open heart surgery under cardiopulmonary bypass. Anhui Medical Pharm J 15:615–617. https://doi.org/10.3969/j.issn.1009-6469.2011.05.040
Liao F, XiaHou GL, Zhong LL (2011) Effect of tranexamic acid on blood loss during cardiopulmonary bypass heart valve replacement. China Medical Guide 09:229–230. https://doi.org/10.3969/j.issn.1671-8194.2011.26.175
Zhang Y, Song JP, Chen ZQ, Zhang H, Zhao Y, Ye S et al (2010) The optimal application time of tranexamic acid in the cardiac valve replacement with cardiopulmonary bypass to reduce postoperative bleeding. Acta Universitatis Medicinalis Aanjing (Nat Sci) 30:1448–1051
Zhang SJ, Zhu DM, Shen J, Wang W (2010) The effects of tranexamic acid in pediatric extracorporeal circulation. China J ECC 08:166–168. https://doi.org/10.3969/j.issn.1672-1403.2010.03.011
Wang LH, Zhou SJ, Wang X (2010) Effect of tranexamic acid on postoperative hemostasis and inflammatory mediators in infants with congenital heart disease: a randomized controlled trial. China J Evid Pediatr 06:420–424. https://doi.org/10.3969/j.issn.1008-6358.2010.01.043
留言 (0)