Verhoeven F, Totoson P, Marie C, Prigent-Tessier A, Wendling D, Tournier-Nappey M, Prati C, Demougeot C. Diclofenac but not celecoxib improves endothelial function in rheumatoid arthritis: A study in adjuvant-induced arthritis. Atherosclerosis. 2017;266:136–44. https://doi.org/10.1016/j.atherosclerosis.2017.09.033.

Article  CAS  PubMed  Google Scholar 

Wongrakpanich S, Wongrakpanich A, Melhado K, Rangaswami J. A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly. Aging and Disease. 2018;9:143–150. https://doi.org/10.14336/ad.2017.0306.

Tielemans MM, Jaspers Focks J, van Rossum LG, Eikendal T, Jansen JB, Laheij RJ, van Oijen MG. Gastrointestinal symptoms are still prevalent and negatively impact health-related quality of life: a large cross-sectional population based study in The Netherlands. PLoS ONE. 2013;8: e69876. https://doi.org/10.1371/journal.pone.0069876.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang M, Fang L. Percutaneous absorption of diclofenac acid and its salts from emulgel. Asian J Pharm Sci. 2008;3:131–41. https://doi.org/10.1016/0378-5173(85)90149-8.

Article  Google Scholar 

Jaber N, Al-Akayleh F, Abdel-Rahem RA, Al-Remawi M. Characterization ex vivo skin permeation and pharmacological studies of ibuprofen lysinate-chitosan-gold nanoparticles. J Drug Deliv. 2021;62: 102399. https://doi.org/10.1016/j.jddst.2021.102399.

Article  CAS  Google Scholar 

Lu Y, Fan L, Yang L-Y, Huang F, Ouyang X-K. PEI-modified core-shell/bead-like amino silica enhanced poly (vinyl alcohol)/chitosan for diclofenac sodium efficient adsorption. Carbohydr Polym. 2020;229:115459. https://doi.org/10.1016/j.carbpol.2019.115459.

Hajjar B, Zier K-I, Khalid N, Azarmi S, Löbenberg R. Evaluation of a microemulsion-based gel formulation for topical drug delivery of diclofenac sodium. J Pharm Investig. 2018;48:351–62. https://doi.org/10.1007/s40005-017-0327-7.

Article  CAS  Google Scholar 

Pedro SN, Mendes MSM, Neves BM, Almeida IF, Costa P, Correia-Sá I, Vilela C, Freire MG, Silvestre AJD, Freire CSR. Deep Eutectic Solvent Formulations and Alginate-Based Hydrogels as a New Partnership for the Transdermal Administration of Anti-Inflammatory Drugs. Pharmaceutics. 2022. [Epub ahead of print] https://doi.org/10.3390/pharmaceutics14040827.

Jesus AR, Meneses L, Duarte ARC, Paiva A. Natural deep eutectic systems, an emerging class of cryoprotectant agents. Cryobiology. 2021;101:95–104. https://doi.org/10.1016/j.cryobiol.2021.05.002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Earle MJ, Seddon KR. Ionic liquids. Green solvents for the future. Pure Appl Chem. 2000;72:1391–1398. https://doi.org/10.1351/pac200072071391.

Al-Akayleh F, Khalid RM, Hawash D, Al-Kaissi E, Al-Adham ISI, Al-Muhtaseb N, Jaber N, Al-Remawi M, Collier PJ. Antimicrobial potential of natural deep eutectic solvents. Lett Appl Microbiol. 2022;75:607–15. https://doi.org/10.1111/lam.13699.

Article  CAS  PubMed  Google Scholar 

Al-Akayleh F, Adwan S, Khanfar M, Idkaidek N, Al-Remawi M. A Novel Eutectic-Based Transdermal Delivery System for Risperidone. AAPS PharmSciTech. 2020;22:4. https://doi.org/10.1208/s12249-020-01844-4.

Article  CAS  PubMed  Google Scholar 

Daadoue S, Al-Remawi MD, Al-Mawla L, Idkaidek NM, Khalid RM, Al-Akayleh F. Deep Eutectic Liquid as Transdermal Delivery Vehicle of Risperidone. J Mol Liq. 2021. https://doi.org/10.1016/j.molliq.2021.117347.

Article  Google Scholar 

Al-Akayleh F, Mohammed Ali HH, Ghareeb MM, Al-Remawi M. Therapeutic deep eutectic system of capric acid and menthol: Characterization and pharmaceutical application. J Drug Deliv Sci Technol. 2019;53: 101159. https://doi.org/10.1016/j.jddst.2019.101159.

Article  CAS  Google Scholar 

Ali HH, Ghareeb MM, Al-Remawi M, Al-Akayleh FT. New insight into single phase formation of capric acid/menthol eutectic mixtures by Fourier-transform infrared spectroscopy and differential scanning calorimetry. Trop J Pharm Res. 2020;19:361–9. https://doi.org/10.4314/tjpr.v19i2.19.

Article  CAS  Google Scholar 

Luhaibi DK, Ali HHM, Al-Ani I, Shalan N, Al-Akayleh F, Al-Remawi M, Nasereddin J, Qinna NA, Al-Adham I, Khanfar M. The Formulation and Evaluation of Deep Eutectic Vehicles for the Topical Delivery of Azelaic Acid for Acne Treatment. Molecules. 2023;28:6927. https://doi.org/10.3390/molecules28196927.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alkhawaja B, Al-Akayleh F, Al-Khateeb A, Nasereddin J, Ghanim BY, Bolhuis A, Qinna NA. Deep Eutectic Liquids as a Topical Vehicle for Tadalafil: Characterisation and Potential Wound Healing and Antimicrobial Activity. Molecules. 2023;28(5):2402.‏ https://doi.org/10.3390/molecules28052402.

Kang L, Jun HW, McCall JW. Physicochemical studies of lidocaine–menthol binary systems for enhanced membrane transport. Int J Pharm. 2000;206:35–42. https://doi.org/10.1016/S0378-5173(00)00505-6.

Article  CAS  PubMed  Google Scholar 

Kaplun-Frischoff Y, Touitou E. Testosterone Skin Permeation Enhancement by Menthol through Formation of Eutectic with Drug and Interaction with Skin Lipids. J Pharm Sci. 1997;86:1394–9. https://doi.org/10.1021/js9701465.

Article  CAS  PubMed  Google Scholar 

Stott PW, Williams AC, Barry BW. Transdermal delivery from eutectic systems: enhanced permeation of a model drug, ibuprofen. J Control Release. 1998;50:297–308. https://doi.org/10.1016/S0168-3659(97)00153-3.

Article  CAS  PubMed  Google Scholar 

Stott PW, Williams AC, Barry BW. Mechanistic study into the enhanced transdermal permeation of a model β-blocker, propranolol, by fatty acids: a melting point depression effect. Int J Pharm. 2001;219:161–76. https://doi.org/10.1016/S0378-5173(01)00645-7.

Article  CAS  PubMed  Google Scholar 

Parakh D. SELF MICRO-EMULSIFYING DRUG DELIVERY SYSTEM: APPROACH TO IMPROVE SOLUBILITY AND PERMEABILITY. Int j inst pharm. 2015;5:21–37. https://doi.org/10.3109/10717544.2014.896058.

Article  CAS  Google Scholar 

Ibrahim MA, El-Badry M. Formulation of immediate release pellets containing famotidine solid dispersions. Saudi Pharm J. 2014;22:149–56. https://doi.org/10.1016/j.jsps.2013.01.011.

Article  PubMed  Google Scholar 

Dutok Sánchez C, Berenguer Rivas C, Rodríguez-Leblanch E, Pérez-Jackson L, Chil I, Escalona Arranz J, Reyes-Tur B, Queiroz M. Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of “Zapote” Pouteria mammosa (L.) Cronquist. Sci World J. 2015;1. https://doi.org/10.1155/2015/642906.

Kim S-H, Heo Y, Choi S-J, Kim Y-J, Kim M-S, Kim H, Jo E, Song C-W, Lee K. Safety evaluation of zinc oxide nanoparticles in terms of acute dermal toxicity, dermal irritation and corrosion, and skin sensitization. Mol Cell Toxicol. 2016;12:93–9. https://doi.org/10.1007/s13273-016-0012-3.

Article  CAS  Google Scholar 

Kligman AM, Christophers E. Preparation of isolated sheets of human stratum corneum. Arch Dermatol. 1963;88:702–5. https://doi.org/10.1001/archderm.1963.01590240026005.

Article  CAS  PubMed  Google Scholar 

Al-Akayleh F, Jaber N, Al-Remawi M, Al Odwan G, Qinna N. Chitosan-biotin topical film: Preparation and evaluation of burn wound healing activity. Pharm Dev Technol. 2022;27:479–89. https://doi.org/10.1080/10837450.2022.2079132.

Article  CAS  PubMed  Google Scholar 

Ribeiro BD, Florindo C, Iff LdC, Coelho MAZ, Marrucho IM. Menthol-based Eutectic Mixtures: Hydrophobic Low Viscosity Solvents. ACS Sustain Chem Eng. 2015;3:2469–2477. https://doi.org/10.1021/acssuschemeng.5b00532.

Prahlada Rao S, Sunkada S. Making sense of boiling points and melting points. Resonance. 2007;12:43–57. https://doi.org/10.1007/s12045-007-0059-5.

Article  Google Scholar 

Roberts JD, Caserio MC. Basic principles of organic chemistry: WA Benjamin, Inc. 1977.

Xu G-C, Ding J-C, Han R-Z, Dong J-J, Ni Y. Enhancing cellulose accessibility of corn stover by deep eutectic solvent pretreatment for butanol fermentation. Bioresour Technol. 2016;203:364–9. https://doi.org/10.1016/j.biortech.2015.11.002.

Article  CAS  PubMed  Google Scholar 

Lynch ML, Wireko F, Tarek M, Klein M. Intermolecular interactions and the structure of fatty acid− soap crystals. J Phys Chem B. 2001;105:552–61. https://doi.org/10.1021/jp002602a.

Article  CAS  Google Scholar 

Abo-Hamad A, Hayyan M, AlSaadi MA, Hashim MA. Potential applications of deep eutectic solvents in nanotechnology. J Chem Eng. 2015;273:551–67. https://doi.org/10.1016/j.cej.2015.03.091.

Article  CAS  Google Scholar 

Luo J, Conrad O, Vankelecom IFJ. Physicochemical properties of phosphonium-based and ammonium-based protic ionic liquids. J Mater. 2012;22:20574–9. https://doi.org/10.1039/C2JM34359B.

Article  CAS  Google Scholar 

Bratož S, Hadži D, Sheppard N. The infra-red absorption bands associated with the COOH and COOD groups in dimeric carboxylic acid—II: The region from 3700 to 1500 cm−1. Spectrochim. 1956;8:249–61. https://doi.org/10.1016/0371-1951(56)80031-3.

Article  Google Scholar 

Beare-Rogers JL, Dieffenbacher A, Holm JV. Lexicon of lipid nutrition (IUPAC Technical Report). Pure Appl Chem. 2001;73:685–744. https://doi.org/10.1351/pac200173040685.

Article  CAS  Google Scholar 

Song W, Zhao Z, Zheng H, Wang G. Gamma-irradiation synthesis of quaternary phosphonium cationic starch flocculants. Water science and technology : a journal of the International Association on Water Pollution Research. 2013;68:1778–84. https://doi.org/10.2166/wst.2013.351.

Article  CAS  PubMed  Google Scholar 

Socrates G. Infrared characteristic group frequencies: tables and charts. (No Title) 1995.

Phaechamud T, Tuntarawongsa S, Charoensuksai P. Evaporation Behavior and Characterization of Eutectic Solvent and Ibuprofen Eutectic Solution. AAPS PharmSciTech. 2016;17:1213–20. https://doi.org/10.1208/s12249-015-0459-x.

Article  CAS  PubMed  Google Scholar 

Martín-Acebes MA, Vázquez-Calvo Á, Caridi F, Saiz J-C, Sobrino F. Lipid involvement in viral infections: present and future perspectives for the design of antiviral strategies. Lipid Metabolism. 2013;291–322. https://doi.org/10.5772/51068.

ten Grotenhuis E, van Aken GA, van Malssen KF, Schenk H. Polymorphism of milk fat studied by differential scanning calorimetry and real-time X-ray powder diffraction. JAOCS. 1999;76:1031–9. https://doi.org/10.1007/s11746-999-0201-5.

Article  Google Scholar 

Aroso IM, Silva JC, Mano F, Ferreira ASD, Dionísio M, Sá-Nogueira I, Barreiros S, Reis RL, Paiva A, Duarte ARC. Dissolution enhancement of active pharmaceutical ingredients by therapeutic deep eutectic systems. Eur J Pharm Biopharm. 2016;98:57–66. https://doi.org/10.1016/j.ejpb.2015.11.002.

Article  CAS  PubMed