Madersbacher H, van Ophoven A, van Kerrebroeck PE. GAG layer replenishment therapy for chronic forms of cystitis with intravesical glycosaminoglycans—a review. Neurourol Urodyn. 2013;32(1):9–18.

Article  CAS  PubMed  Google Scholar 

Lazzeri M, Hurle R, Casale P, Buffi N, Lughezzani G, Fiorini G, Peschechera R, Pasini L, Zandegiacomo S, Benetti A, Taverna G, Guazzoni G, Barbagli G. Managing chronic bladder diseases with the administration of exogenous glycosaminoglycans: an update on the evidence. Ther Adv Urol. 2016;8(2):91–9.

Article  CAS  PubMed  Google Scholar 

Damiano R, Cicione A. The role of sodium hyaluronate and sodium chondroitin sulphate in the management of bladder disease. Ther Adv Urol. 2011;3(5):223–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanai AJ. Afferent mechanism in the urinary tract. Handb Exp Pharmacol. 2011;202:171–205.

Article  CAS  Google Scholar 

Arms L, Vizzard MA. Neuropeptides in lower urinary tract function. Handb Exp Pharmacol. 2011;202:395–423.

Article  CAS  Google Scholar 

Lilly JD, Parsons CL. Bladder surface glycosaminoglycans is a human epithelial permeability barrier. Surg Gynecol Obstet. 1990;171(6):493–6.

CAS  PubMed  Google Scholar 

Geppetti P, Nassini R, Materazzi S, Benemei S. The concept of neurogenic inflammation. BJU Int. 2008;101(Suppl 3):2–6.

Article  CAS  PubMed  Google Scholar 

Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am J Med. 2002;8(113 Suppl 1A):5S-13S.

Article  Google Scholar 

Ikäheimo R, Siitonen A, Heiskanen T, Kärkkäinen U, Kuosmanen P, Lipponen P, Mäkelä PH. Recurrence of urinary tract infection in a primary care setting: analysis of a 1-year follow-up of 179 women. Clin Infect Dis. 1996;22(1):91–9.

Article  PubMed  Google Scholar 

Foxman B. The epidemiology of urinary tract infection. Nat Rev Urol. 2010;7(12):653–60.

Article  PubMed  Google Scholar 

Vahlensieck W, Perepanova T, Bjerklund Johansen TE, Tenke P, Naber KG, Wagenlehner FE. Management of Uncomplicated Recurrent Urinary Tract Infections. Eur Urol Suppl. 2016;15(4):95–101.

Article  Google Scholar 

Stamey TA. Recurrent urinary tract infections in female patients: an overview of management and treatment. Rev Infect Dis. 1987;9(2):S195-210.

Article  PubMed  Google Scholar 

Schaeffer AJ. Recurrent urinary tract infections in women. Pathogenesis Manag Postgrad Med. 1987;81(3):51–8.

Article  CAS  Google Scholar 

Fowler JE Jr. Urinary tract infections in women. Urol Clin North Am. 1986;13(4):673–83.

Article  PubMed  Google Scholar 

Rosen DA, Hooton TM, Stamm WE, Humphrey PA, Hultgren SJ. Detection of intracellular bacterial communities in human urinary tract infection. PLoS Med. 2007;4(12): e329.

Article  PubMed  PubMed Central  Google Scholar 

Poggi MM, Johnstone PA, Conner RJ. Glycosaminoglycan content of human bladders. A method of analysis using cold-cup biopsies. Urol Oncol. 2000;5(5):234–7.

Article  CAS  PubMed  Google Scholar 

Morales A, Emerson L, Nickel JC. Intravesical hyaluronic acid in the treatment of refractory interstitial cystitis. Urology. 1997;49(5A Suppl):111–3.

Article  CAS  PubMed  Google Scholar 

Parsons CL. Epithelial coating techniques in the treatment of interstitial cystitis. Urology. 1997;49(5A Suppl):100–4.

Article  CAS  PubMed  Google Scholar 

Cicione A, Cantiello F, Ucciero G, Salonia A, Madeo I, Bava I, Aliberti A, Damiano R. Restoring the glycosaminoglycans layer in recurrent cystitis: experimental and clinical foundations. Int J Urol. 2014;21(8):763–8.

Article  PubMed  Google Scholar 

Neugent ML, Hulyalkar NV, Kumar A, Xing C, Zimmern PE, Shulaev V, De Nisco NJ. Urinary Glycosaminoglycans Are Associated with Recurrent UTI and Urobiome Ecology in Postmenopausal Women. ACS Infect Dis. 2023;9(4):1022–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Naber KG, Bonkat G, Wagenlehner FME. The EAU and AUA/CUA/SUFU Guidelines on Recurrent Urinary Tract Infections: What is the Difference? Eur Urol. 2020;78(5):645–6.

Article  PubMed  Google Scholar 

Tasdemir S, Tasdemir C, Vardi N, Yakupogullari Y, Duman Y, Parlakpinar H, Sagir M, Acet A. Intravesical hyaluronic acid and chondroitin sulfate alone and in combination for urinary tract infection: assessment of protective effects in a rat model. Int J Urol. 2012;19(12):1108–12.

Article  CAS  PubMed  Google Scholar 

Damiano R, Quarto G, Bava I, Ucciero G, De Domenico R, Palumbo MI, Autorino R. Prevention of recurrent urinary tract infections by intravesical administration of hyaluronic acid and chondroitin sulphate: a placebo-controlled randomised trial. Eur Urol. 2011;59(4):645–51.

Article  CAS  PubMed  Google Scholar 

Damiano R, Quarto G, Bava I, Ucciero G, De Domenico R, Palumbo MI, Autorino R. Corrigendum to "Prevention of Recurrent Urinary Tract Infections by Intravesical Administration of Hyaluronic Acid and Chondroitin Sulphate: A Placebo-Controlled Randomised Trial [Eur Urol 2011;59:645–51]. Eur Urol. 2011;60(1):193.

Article  CAS  PubMed  Google Scholar 

De Vita D, Giordano S. Effectiveness of intravesical hyaluronic acid/chondroitin sulfate in recurrent bacterial cystitis: a randomized study. Int Urogynecol J. 2012;23(12):1707–13.

Article  PubMed  Google Scholar 

Torella M, Schettino MT, Salvatore S, Serati M, De Franciscis P, Colacurci N. Intravesical therapy in recurrent cystitis: a multi-center experience. J Infect Chemother. 2013;19(5):920–5.

Article  CAS  PubMed  Google Scholar 

Cicione A, Cantiello F, Ucciero G, Salonia A, Torella M, De Sio M, Autorino R, Carbone A, Romancik M, Tomaskin R, Damiano R. Intravesical treatment with highly-concentrated hyaluronic acid and chondroitin sulphate in patients with recurrent urinary tract infections: Results from a multicentre survey. Can Urol Assoc J. 2014;8(9–10):E721–7.

Article  PubMed  PubMed Central  Google Scholar 

Gugliotta G, Calagna G, Adile G, Polito S, Saitta S, Speciale P, Palomba S, Perino A, Granese R, Adile B. Is intravesical instillation of hyaluronic acid and chondroitin sulfate useful in preventing recurrent bacterial cystitis? A multicenter case control analysis. Taiwan J Obstet Gynecol. 2015;54(5):537–40.

Article  PubMed  Google Scholar 

Ciani O, Arendsen E, Romancik M, Lunik R, Costantini E, Di Biase M, Morgia G, Fragalà E, Roman T, Bernat M, Guazzoni G, Tarricone R, Lazzeri M. Intravesical administration of combined hyaluronic acid (HA) and chondroitin sulfate (CS) for the treatment of female recurrent urinary tract infections: a European multicentre nested case-control study. BMJ Open. 2016;6(3): e009669.

Article  PubMed  PubMed Central  Google Scholar 

De Vita D, Antell H, Giordano S. Effectiveness of intravesical hyaluronic acid with or without chondroitin sulfate for recurrent bacterial cystitis in adult women: a meta-analysis. Int Urogynecol J. 2013;24(4):545–52.

Article  PubMed  Google Scholar 

Goddard JC, Janssen DAW. Intravesical hyaluronic acid and chondroitin sulfate for recurrent urinary tract infections: systematic review and meta-analysis. Int Urogynecol J. 2018;29(7):933–42.

Article  PubMed  Google Scholar 

EAU Guidelines. Edn. presented at the EAU Annual Congress Milan 2021. ISBN 978-94-92671-13-4.

EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam, the Netherlands 2022. ISBN 978-94-92671-16-5

Fall M, Baranowski AP, Elneil S, Engeler D, Hughes J, Messelink EJ, Oberpenning F, de C Williams AC; European Association of Urology. EAU guidelines on chronic pelvic pain. Eur Urol. 2010;57(1):35–48

Konkle KS, Berry SH, Elliott MN, Hilton L, Suttorp MJ, Clauw DJ, Clemens JQ. Comparison of an interstitial cystitis/bladder pain syndrome clinical cohort with symptomatic community women from the RAND Interstitial Cystitis Epidemiology study. J Urol. 2012;187(2):508–12.

Article  PubMed  Google Scholar 

Berry SH, Elliott MN, Suttorp M, Bogart LM, Stoto MA, Eggers P, Nyberg L, Clemens JQ. Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States. J Urol. 2011;186(2):540–4.

Article  PubMed  PubMed Central  Google Scholar 

Han XM, Wu XH, Li B, Pan F, Li WC, Liu SL, Zeng FQ, Chen M. The effects of intravesical therapy with hyaluronic acid for painful bladder syndrome: Preliminary Chinese experience and systematic review. Taiwan J Obstet Gynecol. 2015;54(3):240–7.

Article  PubMed  Google Scholar 

Parsons CL. The role of a leaky epithelium and potassium in the generation of bladder symptoms in interstitial cystitis/overactive bladder, urethral syndrome, prostatitis and gynaecological chronic pelvic pain. BJU Int. 2011;107(3):370–5.

Article  PubMed  Google Scholar 

Hurst RE. Structure, function, and pathology of proteoglycans and glycosaminoglycans in the urinary tract. World J Urol. 1994;12(1):3–10.

Article  CAS  PubMed  Google Scholar 

Danacioglu YO, Erol B, Ozkanli S, Yildirim A, Atis RG, Silay MS, Caskurlu T. Comparison of Intravesical Hyaluronic Acid, Chondroitin Sulfate, and Combination of Hyaluronic Acid-Chondroitin Sulfate Therapies in Animal Model of Interstitial Cystitis. Int Neurourol J. 2021;25(1):42–50.

Article  PubMed  PubMed Central