L. Gong, D.L. Kwong, W. Dai, P. Wu, Y. Wang, A.W. Lee, X.Y. Guan, The stromal and immune landscape of nasopharyngeal carcinoma and its implications for precision medicine targeting the tumor microenvironment. Front. Oncol. 11, 744889 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Y.P. Chen, J.H. Yin, W.F. Li, H.J. Li, D.P. Chen, C.J. Zhang, J.W. Lv, Y.Q. Wang, X.M. Li, J.Y. Li, P.P. Zhang, Y.Q. Li, Q.M. He, X.J. Yang, Y. Lei, L.L. Tang, G.Q. Zhou, Y.P. Mao, C. Wei, K.X. Xiong, H.B. Zhang, S.D. Zhu, Y. Hou, Y. Sun, M. Dean, I. Amit, K. Wu, D.M. Kuang, G.B. Li, N. Liu, J. Ma, Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma. Cell Res. 30, 1024–1042 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M. Yi, J. Cai, J. Li, S. Chen, Z. Zeng, Q. Peng, Y. Ban, Y. Zhou, X. Li, W. Xiong, G. Li, B. Xiang, Rediscovery of NF-kappaB signaling in nasopharyngeal carcinoma: How genetic defects of NF-kappaB pathway interplay with EBV in driving oncogenesis? J. Cell. Physiol. 233, 5537–5549 (2018)

Article  CAS  PubMed  Google Scholar 

W. Wang, M. Yi, R. Zhang, J. Li, S. Chen, J. Cai, Z. Zeng, X. Li, W. Xiong, L. Wang, G. Li, B. Xiang, Vimentin is a crucial target for anti-metastasis therapy of nasopharyngeal carcinoma. Mol. Cell. Biochem. 438, 47–57 (2018)

Article  CAS  Google Scholar 

X. Shi, J. Pan, F. Qiu, L. Wu, X. Zhang, Y. Feng, X. Gu, J. Zhao, W. Zheng, Multiscale transcriptomic integration reveals B-Cell depletion and T-Cell mistrafficking in nasopharyngeal carcinoma progression. Front. Cell Dev. Biol. 10, 857137 (2022)

Article  PubMed  PubMed Central  Google Scholar 

Y. Mo, Y. Wang, Y. Wang, X. Deng, Q. Yan, C. Fan, S. Zhang, S. Zhang, Z. Gong, L. Shi, Q. Liao, C. Guo, Y. Li, G. Li, Z. Zeng, W. Jiang, W. Xiong, B. Xiang, Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the beta-TrCP/c-Myc/SRSF1 positive feedback loop. Mol. Cancer 21, 192 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

R. Miao, C.C. Dai, L. Mei, J. Xu, S.W. Sun, Y.L. Xing, L.S. Wu, M.H. Wang, J.F. Wei, KIAA1429 regulates cell proliferation by targeting c-Jun messenger RNA directly in gastric cancer. J. Cell. Physiol. 235, 7420–7432 (2020)

Article  CAS  PubMed  Google Scholar 

B.J. Gentil, C. Delphin, C. Benaud, J. Baudier, Expression of the giant protein AHNAK (desmoyokin) in muscle and lining epithelial cells. J. Histochem. Cytochem. 51, 339–348 (2003)

Article  CAS  PubMed  Google Scholar 

K. Tezuka, M. Suzuki, R. Sato, S. Kawarada, T. Terasaki, Y. Uchida, Activation of Annexin A2 signaling at the blood-brain barrier in a mouse model of multiple sclerosis. J. Neurochem. 160, 662–674 (2022)

Article  CAS  PubMed  Google Scholar 

T. Mirzapoiazova, F.E. Lennon, B. Mambetsariev, M. Allen, J. Riehm, V.A. Poroyko, P.A. Singleton, Extracellular vesicles from caveolin-enriched microdomains regulate hyaluronan-mediated sustained vascular integrity. Int. J. Cell Biol. 2015, 481493 (2015)

Article  PubMed  PubMed Central  Google Scholar 

A. Rezvanpour, L. Santamaria-Kisiel, G.S. Shaw, The S100A10-annexin A2 complex provides a novel asymmetric platform for membrane repair. J. Biol. Chem. 286, 40174–40183 (2011)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A. Lorusso, C. Covino, G. Priori, A. Bachi, J. Meldolesi, E. Chieregatti, Annexin2 coating the surface of enlargeosomes is needed for their regulated exocytosis. EMBO J. 25, 5443–5456 (2006)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A. Diaz-Diaz, D. Roca-Lema, A. Casas-Pais, G. Romay, G. Colombo, A. Concha, B. Grana, A. Figueroa, Heat shock protein 90 chaperone regulates the E3 Ubiquitin-Ligase Hakai protein stability. Cancers (Basel) 12, 215 (2020)

Article  CAS  PubMed  Google Scholar 

S. Jin, Y. Mi, J. Song, P. Zhang, Y. Liu, PRMT1-RBM15 axis regulates megakaryocytic differentiation of human umbilical cord blood CD34(+) cells. Exp. Ther. Med. 15, 2563–2568 (2018)

CAS  PubMed  PubMed Central  Google Scholar 

A. Pascal, E. Gallaud, R. Giet, C. Benaud, Annexin A2 and Ahnak control cortical NuMA-dynein localization and mitotic spindle orientation. J. Cell Sci. 135, 259344 (2022)

I. Prada, E. Cocucci, G. Racchetti, J. Meldolesi, The Ca2+-dependent exocytosis of enlargeosomes is greatly reinforced by genistein via a non-tyrosine kinase-dependent mechanism. FEBS Lett. 581, 4932–4936 (2007)

Article  CAS  PubMed  Google Scholar 

E. Cocucci, G. Racchetti, P. Podini, M. Rupnik, J. Meldolesi, Enlargeosome, an exocytic vesicle resistant to nonionic detergents, undergoes endocytosis via a nonacidic route. Mol. Biol. Cell 15, 5356–5368 (2004)

Article  CAS  PubMed  PubMed Central  Google Scholar 

F. Colombo, G. Racchetti, J. Meldolesi, Neurite outgrowth induced by NGF or L1CAM via activation of the TrkA receptor is sustained also by the exocytosis of enlargeosomes. Proc. Natl. Acad. Sci. U. S. A. 111, 16943–16948 (2014)

Article  CAS  PubMed  PubMed Central  Google Scholar 

C. Schulte, G. Racchetti, R. D’Alessandro, J. Meldolesi, A new form of neurite outgrowth sustained by the exocytosis of enlargeosomes expressed under the control of REST. Traffic 11, 1304–1314 (2010)

Article  CAS  PubMed  Google Scholar 

G. Racchetti, A. Lorusso, C. Schulte, D. Gavello, V. Carabelli, R. D’Alessandro, J. Meldolesi, Rapid neurite outgrowth in neurosecretory cells and neurons is sustained by the exocytosis of a cytoplasmic organelle, the enlargeosome. J. Cell Sci. 123, 165–170 (2010)

Article  CAS  PubMed  Google Scholar 

W.C. Cho, J.E. Jang, K.H. Kim, B.C. Yoo, J.L. Ku, SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines. Int. J. Oncol. 56, 1140–1151 (2020)

CAS  PubMed  PubMed Central  Google Scholar 

B. Chen, J. Wang, D. Dai, Q. Zhou, X. Guo, Z. Tian, X. Huang, L. Yang, H. Tang, X. Xie, AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer. J. Exp. Clin. Cancer Res. 36, 65 (2017)

Article  PubMed  PubMed Central  Google Scholar 

E. Shen, X. Wang, X. Liu, M. Lv, L. Zhang, G. Zhu, Z. Sun, MicroRNA-93-5p promotes epithelial-mesenchymal transition in gastric cancer by repressing tumor suppressor AHNAK expression. Cancer Cell Int. 20, 76 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Z.M. Liu, X.L. Yang, F. Jiang, Y.C. Pan, L. Zhang, Matrine involves in the progression of gastric cancer through inhibiting miR-93-5p and upregulating the expression of target gene AHNAK. J. Cell. Biochem. 121, 2467–2477 (2020)

Article  CAS  PubMed  Google Scholar 

J.W. Park, I.Y. Kim, J.W. Choi, H.J. Lim, J.H. Shin, Y.N. Kim, S.H. Lee, Y. Son, M. Sohn, J.K. Woo, J.H. Jeong, C. Lee, Y.S. Bae, J.K. Seong, AHNAK loss in mice promotes type II pneumocyte hyperplasia and lung tumor development. Mol. Cancer Res. 16, 1287–1298 (2018)

Article  CAS  PubMed  Google Scholar 

Z. Zhang, X. Liu, R. Huang, X. Liu, Z. Liang, T. Liu, Upregulation of nucleoprotein AHNAK is associated with poor outcome of pancreatic ductal adenocarcinoma prognosis via mediating epithelial-mesenchymal transition. J. Cancer 10, 3860–3870 (2019)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J.S. Shafran, G.P. Andrieu, B. Gyorffy, G.V. Denis, BRD4 regulates metastatic potential of castration-resistant prostate cancer through AHNAK. Mol. Cancer Res. 17, 1627–1638 (2019)

Article  CAS  PubMed  PubMed Central  Google Scholar 

T.A. Silva, B. Smuczek, I.C. Valadao, L.M. Dzik, R.P. Iglesia, M.C. Cruz, A. Zelanis, A.S. de Siqueira, S.M. Serrano, G.S. Goldberg, R.G. Jaeger, V.M. Freitas, AHNAK enables mammary carcinoma cells to produce extracellular vesicles that increase neighboring fibroblast cell motility. Oncotarget 7, 49998–50016 (2016)

Article  PubMed  PubMed Central  Google Scholar 

W. Liu, Y. Pan, H. Zhu, Y. Zhou, H. Zhang, L. Liu, Q. Liu, G. Ji, CircRNA_0008194 functions as a ceRNA to promote invasion of hepatocellular carcinoma via inhibiting miR-190a/AHNAK signaling pathway. J. Clin. Lab. Anal. 36, e24286 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

R. Peng, P.F. Zhang, X. Yang, C.Y. Wei, X.Y. Huang, J.B. Cai, J.C. Lu, C. Gao, H.X. Sun, Q. Gao, D.S. Bai, G.M. Shi, A.W. Ke, J. Fan, Overexpression of RNF38 facilitates TGF-beta signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma. J. Exp. Clin. Cancer Res. 38, 113 (2019)

Article  PubMed  PubMed Central  Google Scholar 

V.V. Sobolev, A.Z. Khashukoeva, O.E. Evina, N.A. Geppe, S.N. Chebysheva, I.M. Korsunskaya, E. Tchepourina, A. Mezentsev, Role of the transcription factor FOSL1 in organ development and tumorigenesis. Int. J. Mol. Sci. 23, 1521 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A. Usui, I. Hoshino, Y. Akutsu, H. Sakata, T. Nishimori, K. Murakami, M. Kano, K. Shuto, H. Matsubara, The molecular role of Fra-1 and its prognostic significance in human esophageal squamous cell carcinoma. Cancer 118, 3387–3396 (2012)

Article  CAS  PubMed  Google Scholar 

A.E. Sayan, R. Stanford, R. Vickery, E. Grigorenko, J. Diesch, K. Kulbicki, R. Edwards, R. Pal, P. Greaves, I. Jariel-Encontre, M. Piechaczyk, M. Kriajevska, J.K. Mellon, A.S. Dhillon, E. Tulchinsky, Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL. Oncogene 31, 1493–1503 (2012)

Article  CAS  PubMed