Medinger M, Drexler B, Lengerke C, Passweg J. Pathogenesis of acquired aplastic anemia and the role of the bone marrow microenvironment. Front Oncol. 2018;8:587.
Article PubMed PubMed Central Google Scholar
Peslak SA, Olson T, Babushok DV. Diagnosis and treatment of aplastic anemia. Curr Treat Options Oncol. 2017;18:70.
Article PubMed PubMed Central Google Scholar
Young NS. Aplastic anemia. N Engl J Med. 2018;379:1643–56.
Article CAS PubMed PubMed Central Google Scholar
Killick SB, Bown N, Cavenagh J, et al. Guidelines for the diagnosis and management of adult aplastic anaemia. Br J Haematol. 2015;172:187–207.
Frickenhofen N, Heimpel H, Kaltwasser JP, Schrezenmeier H. Antithymocyte globulin with or without cyclosporin A: 11-year follow-up of a randomized trial comparing treatments of aplastic anemia. Blood. 2003;101:1236–42.
Tichelli A, Schrezenmeier H, Socié G, et al. A randomized controlled study in patients with newly diagnosed severe aplastic anemia receiving antithymocyte globulin (ATG), cyclosporine, with or without G-CSF: a study of the SAA Working Party of the European Group for Blood and Marrow Transplantation. Blood. 2011;117:4434–41.
Article CAS PubMed Google Scholar
Rosenfeld S, Vollmann D, Nunez O, Young NS. Antithymocyte globulin and cyclosporine for severe aplastic anemia. JAMA. 2003;289:1130–5.
Article CAS PubMed Google Scholar
Scheinberg P, Wu CO, Nunez O, et al. Treatment of severe aplastic anemia with a combination of horse antithymocyte globulin and cyclosporine, with or without sirolimus: a prospective randomized study. Haematologica. 2009;94:348–54.
Article CAS PubMed PubMed Central Google Scholar
Promacta. Package insert. Novartis Pharmaceuticals Corporation; 2021.
Townsley DM, Scheinberg P, Winkler T, et al. Eltrombopag added to standard immunosuppression for aplastic anemia. N Engl J Med. 2017;376:1540–50.
Article CAS PubMed PubMed Central Google Scholar
Peffault de Latour R, Kulasekararaj A, Iacobelli S, et al. Eltrombopag added to immunosuppression in severe aplastic anemia N Engl J Med. 2022;386:11–23. https://doi.org/10.1056/NEJMoa2109965.
Zaimoku Y, Patel BA, Shalhoub R, et al. Predicting response of severe aplastic anemia to immunosuppression combined with eltrombopag. Haematologica 2021 [Online ahead of print].
Kadia T, Ravandi F, Daver N, et al. Single-center experience of immunosuppressive therapy with or without eltrombopag in patients with aplastic anemia. Blood. 2015;126:4779.
Assi R, Garcia-Manero G, Ravandi F, et al. Addition of eltrombopag to immunosuppressive therapy in patients with newly diagnosed aplastic anemia. Cancer. 2018;124:4192–201.
Article CAS PubMed Google Scholar
Fang M, Song H, Zhang J, Li S, Shen D, Tang Y. Efficacy and safety of immunosuppressive therapy with or without eltrombopag in pediatric patients with acquired aplastic anemia: a Chinese retrospective study. Pediatr Hematol Oncol J 2021 [Online ahead of print].
Lesmana H, Jacobs T, Boals M, et al. Eltrombopag in children with severe aplastic anemia. Pediatr Blood Cancer. 2021;68: e29066.
Article CAS PubMed Google Scholar
Jie M, Fu L, Li S, et al. Efficacy and safety of eltrombopag in the first-line therapy of severe aplastic anemia in children. Pediatr Hematol Oncol J 2021 [Online ahead of print].
Hwang Y, Gill H, Chan TSY, et al. Eltrombopag in the management of aplastic anaemia: real-world experience in a non-trial setting. Hematol. 2018;23:399–404.
Boddu P, Garcia-Manero G, Ravandi F, et al. Clinical outcomes in adult patients with aplastic anemia: a single institution experience. Am J Hematol. 2017;92:1295–302.
Article CAS PubMed PubMed Central Google Scholar
Imada K, Obara N, Iida H, et al. Eltrombopag in combination with rabbit anti-thymocyte globulin/cyclosporine A in immunosuppressive therapy-naïve patients with aplastic anemia in Japan. Intern Med. 2021;60:1159–68. https://doi.org/10.2169/internalmedicine.6063-20.
Article CAS PubMed Google Scholar
Groarke EM, Patel BA, Gutierrez-Rodrigues F, et al. Eltrombopag added to immunosuppression for children with treatment-naïve severe aplastic anemia. Br J Haematol. 2021;192:605–14.
Article CAS PubMed PubMed Central Google Scholar
Kao SY, Xu W, Brandwein JM, et al. Outcomes of older patients (>60 years) with acquired aplastic anaemia treated with immunosuppressive therapy. Br J Haematol. 2008;143:738–43.
Common Terminology Criteria for Adverse Events (CTCAE) v5.0. National Cancer Institute: Division of Cancer Treatment & Diagnosis;2018. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/ctcae_v5_quick_reference_5x7.pdf. Accessed June 11, 2022.
Bacigalupo A. How I treat acquired aplastic anemia. Blood. 2017;129:1428–36.
Article CAS PubMed Google Scholar
Pritz T, Weinberger B, Grubeck-Lobenstein B. The aging bone marrow and its impact on immune responses in old age. Immunol Lett. 2014;162:310–5.
Article CAS PubMed Google Scholar
Zaimoku Y, Patel BA, Shalhoub R, et al. Predicting response of severe aplastic anemia to immunosuppression combined with eltrombopag. Haematologica. 2022;107:126–33.
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