The impact of leucine supplementation on body composition and glucose tolerance following energy restriction: an 8-week RCT in adults at risk of the metabolic syndrome

World Health Organization. Obesity: Preventing and managing the global epidemic. Geneva; 1997.

Australian Institute of Health and Welfare. General record of incidence of mortality (GRIM) data. Canberra; 2019.

World Health Organization. World health statistics 2020: monitoring health for the SDGs, sustainable development goals. Geneva; 2020.

Park Y, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB. The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988–1994. Arch Intern Med. 2003;163:427–36.

Article  PubMed  PubMed Central  Google Scholar 

Ford E, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the Third National Health and Nutrition Examination Survey. J Am Med Assoc. 2002;287:356–9.

Article  Google Scholar 

Andreadis E, Tsourous GI, Tzavara CK, Georgiopoulos DX, Katsanou PM, Marakomichelakis GE, et al. Metabolic syndrome and incident cardiovascular morbidity and mortality in a Mediterranean hypertensive population. Am J Hypertens. 2007;20:558–64.

Article  PubMed  Google Scholar 

Bales CW, Buhr G. Is obesity bad for older persons? A systematic review of the pros and cons of weight reduction in later life. J Am Med Dir Assoc. 2008;9:302–12.

Article  PubMed  Google Scholar 

Chaston TB, Dixon JB, O’Brien PE. Changes in fat-free mass during significant weight loss: a systematic review. Int J Obes. 2007;31:743–50.

Article  CAS  Google Scholar 

Ravussin E, Lillioja S, Anderson TE, Christin L, Bogardus C. Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. J Clin Invest. 1986;78:1568–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghachem A, Lagacé JC, Brochu M, Dionne IJ. Fat-free mass and glucose homeostasis: is greater fat-free mass an independent predictor of insulin resistance? Ag Clin Exp Res. 2019;31:447–54.

Article  Google Scholar 

Kimball S, Jefferson LS. Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise. J Biol Chem. 2010;285:29027–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anthony JC, Anthony TG, Kimball SR, Jefferson LS. Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. J Nutr. 2001;131:856S–60S.

Article  CAS  PubMed  Google Scholar 

Suryawan A, Jeyapalan AS, Orellana RA, Wilson FA, Nguyen HV, Davis TA. Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation. Am J Physiol Endocrinol Metab. 2008;295:E868–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abidi SA. Roles of branched chain amino acids in metabolic regulation. J Lab Clin Med. 1980;95:475–84.

Google Scholar 

Kurpad AV, Regan MM, Raj T, Gnanou JV. Branched-Chain Amino Acid Requirements in Healthy Adult Human Subjects. Natl Libr Med. 2006;136:256S–63S.

CAS  Google Scholar 

Azadbakht L, Izadi V, Surkan PJ, Esmaillzadeh A. Effect of a High Protein Weight Loss Diet on Weight, High-Sensitivity C-Reactive Protein, and Cardiovascular Risk among Overweight and Obese Women: A Parallel Clinical Trial. Int J Endocrinol. 2013;2013:971724.

Article  PubMed  PubMed Central  Google Scholar 

Burd NA, Yang Y, Moore DR, Tang JE, Tarnopolsky MA, Phillips SM. Greater stimulation of myofibrillar protein synthesis with ingestion of whey protein isolate v. micellar casein at rest and after resistance exercise in elderly men. Br J Nutr. 2012;108:958–62.

Article  CAS  PubMed  Google Scholar 

Dardevet D, Sornet C, Bayle G, Prugnaud J, Pouyet C, Grizard J. Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine supplemented meal. J Nutr. 2002;132:95–100.

Article  CAS  PubMed  Google Scholar 

Duan Y, Li F, Li Y, Tang Y, Kong X, Feng X, et al. The role of leucine and its metabolites in protein and energy metabolism Yehui. Amino Acids. 2016;48:41–51.

Article  CAS  PubMed  Google Scholar 

Tome D. Efficiency of Free Amino Acids in Supporting Muscle Protein Synthesis. NLM. 2022;152:3–4.

Google Scholar 

Newsholme P, Brennan L, Bender K. Amino Acid Metabolism, β-Cell Function, and Diabetes. Diabetes. 2006;55(suppl 2):S39–S47.

Article  CAS  Google Scholar 

Macotela Y, Emanuelli B, Bang AM, Espinoza DO, Boucher J, Beebe K, et al. Dietary leucine - An environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One. 2011;6:0021187.

Article  Google Scholar 

Ispoglou T, White H, Preston T, McElhone S, McKenn J, Hind K. Double-blind, placebo-controlled pilot trial of L-Leucine-enriched amino-acid mixtures on body composition and physical performance in men and women aged 65–75 years. Eur J Clin Nutr. 2016;70:182–8.

Article  CAS  PubMed  Google Scholar 

Verreijen AM, Verlaan S, Engberink MF, Swinkels S. de Vogel-van den Bosch J et al. A high whey protein–leucine, and vitamin D–enriched supplement preserves muscle mass during intentional weight loss in obese older adults: a double-blind randomized controlled trial. Am J Clin Nutr. 2015;101:279–86.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH. Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes 2007;56:1647–54.

Article  CAS  PubMed  Google Scholar 

Liang C, Curry BJ, Brown PL, Zemel MB. Leucine modulates mitochondrial biogenesis and SIRT1-AMPK signaling in C2C12 myotubes. J Nutr Metab. 2014;2014:239750.

Article  PubMed  PubMed Central  Google Scholar 

Westerterp-Plantenga MS, Lemmens SG, Westerterp KR. Dietary protein - its role in satiety, energetics, weight loss and health. Br J Nutr. 2012;108:S105–12.

Article  CAS  PubMed  Google Scholar 

Zhou Y, Jetton TL, Goshorn S, Lynch CJ, She P. Transamination is required for alpha-ketoisocaproate but not leucine to stimulate insulin secretion. J Biol Chem. 2010;285:33718–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McAllan L, Cotter PD, Roche HM, Korpela R, Nilaweera KN. Impact of leucine on energy balance. J Physiol Biochem. 2013;69:155–63.

Article  CAS  PubMed  Google Scholar 

Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009;120:1640–5.

Article  CAS  PubMed  Google Scholar 

Saghaei M. Random allocation software for parallel group randomized trials. BMC Med Res Methodol. 2004;4:26.

Article  PubMed  PubMed Central  Google Scholar 

Schofield W. Predicting basal metabolic rate, new standards and review previous work. Human Nutrition &. Clin Nutr. 1985;39C:5–41.

Google Scholar 

Ekelund U, Sepp H, Brage S, Becker W, Jakes R, Hennings M, et al. Criterion-related validity of the last 7-day, short form of the International Physical Activity Questionnaire in Swedish adults. Public Health Nutr. 2007;9:258–65.

Article  Google Scholar 

Faul F, Erdfelder E, Lang AG, Buchner AG. *Power 3: A flexible statistical power 290 analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175–91.

Article  PubMed  Google Scholar 

Whelton P, Appel LJ, Espeland MA, Applegate WB, Ettinger WH Jr, Kostis JB, et al. Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group. J Am Med Assoc. 1998;279:839–46.

Article  CAS  Google Scholar 

Wing R, Koeske R, Epstein LH, Nowalk MP, Gooding W, Becker D. Long-termeffects of modest weight loss in type II diabetic patients. Arch Intern Med. 1987;147:1749–53.

Article  CAS  PubMed  Google Scholar 

Mann JI. Nutrition recommendations for the treatment and prevention of type 2 diabetes and the metabolic syndrome: an evidenced-based review. Nutr Rev. 2006;64:422–7.

Article  CAS  PubMed  Google Scholar 

Cava E, Yeat NC, Mittendorfer B. Preserving healthy muscle during weight loss. Adv Nutr. 2017;8:511–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dixon JB, Lambert EA, Grima M, Rice T, Lambert GW, Straznicky NE. Fat-free mass loss generated with weight loss in overweight and obese adults: what may we expect? Diab Obes Metab. 2015;17:91–3.

Article  CAS  Google Scholar 

Funderburk L, Heileson J, Peterson M, Willoughby DS. Efficacy of L-Leucine supplementation coupled with a calorie-restricted diet to promote weight loss in mid-life women. J Am Coll Nutr. 2021;40:699–707.

Article  CAS  PubMed  Google Scholar 

Leenders M, Verdijk LB, van der Hoeven L, van Kranenburg J, Hartgens F, Wodzig W, et al. Prolonged leucine supplementation does not augment muscle mass or affect glycemic control in elderly type 2 diabetic men. J Nutr. 2011;141:1070–6.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif