Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7–33.

Article  PubMed  Google Scholar 

Razis E, Kassapian M, Andriakopoulou C, Martei YM, Zurn SJ, Hammad N, et al. Essential medicines list in national cancer control plans: a secondary analysis from a global study. Lancet Oncol. 2022;23:e144–54.

Article  PubMed  Google Scholar 

Cao S, Wang JR, Ji S, Yang P, Dai Y, Guo S, et al. Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression. Nat Biotechnol. 2022;40:1624–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seki S, Tsumaki N, Motomura H, Nogami M, Kawaguchi Y, Hori T, et al. Cartilage intermediate layer protein promotes lumbar disc degeneration. Biochem Biophys Res Commun. 2014;446:876–81.

Article  CAS  PubMed  Google Scholar 

Wang C, Jian W, Luo Q, Cui J, Qing Y, Qin C, et al. Prognostic value of cartilage intermediate layer protein 1 in chronic heart failure. ESC Heart Fail. 2022;9:345–52.

Article  PubMed  Google Scholar 

Li Q, Pu D, Xia X, Liu H, Li L. Serum concentrations of cartilage intermediate layer protein 2 were higher in overweight and obese subjects. Biomed Res Int. 2022;2022:6290064.

PubMed  PubMed Central  Google Scholar 

Zhang CL, Zhao Q, Liang H, Qiao X, Wang JY, Wu D, et al. Cartilage intermediate layer protein-1 alleviates pressure overload-induced cardiac fibrosis via interfering TGF-β1 signaling. J Mol Cell Cardiol. 2018;116:135–44.

Article  CAS  PubMed  Google Scholar 

Sun X, Yang N, Zhou X, Dai H, Li Q, Feng A, et al. CILP, a putative gene associated with immune infiltration in breast cancer brain metastases. Front Genet. 2022;13:862264.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mohan V, Das A, Sagi I. Emerging roles of ECM remodeling processes in cancer. Semin Cancer Biol. 2020;62:192–200.

Article  CAS  PubMed  Google Scholar 

Kalluri R. The biology and function of fibroblasts in cancer. Nat Rev Cancer. 2016;16:582–98.

Article  CAS  PubMed  Google Scholar 

Mhaidly R, Mechta-Grigoriou F. Fibroblast heterogeneity in tumor micro-environment: role in immunosuppression and new therapies. Semin Immunol. 2020;48:101417.

Article  CAS  PubMed  Google Scholar 

Malone ER, Oliva M, Sabatini PJB, Stockley TL, Siu LL. Molecular profiling for precision cancer therapies. Genome Med. 2020;12:8.

Article  PubMed  PubMed Central  Google Scholar 

Vivian J, Rao AA, Nothaft FA, Ketchum C, Armstrong J, Novak A, et al. Toil enables reproducible, open source, big biomedical data analyses. Nat Biotechnol. 2017;35:314–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Macosko EZ, Basu A, Satija R, Nemesh J, Shekhar K, Goldman M, et al. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 2015;161:1202–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Laurens VDM, Hinton G. Visualizing data using t-SNE. J Mach Learn Res. 2008;9:2579–605.

Google Scholar 

Olbrecht S, Busschaert P, Qian J, Vanderstichele A, Loverix L, Van Gorp T, et al. High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing: specific cell subtypes influence survival and determine molecular subtype classification. Genome Med. 2021;13:111.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen YP, Yin JH, Li WF, Li HJ, Chen DP, Zhang CJ, et al. Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma. Cell Res. 2020;30:1024–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sebastian A, Hum NR, Martin KA, Gilmore SF, Peran I, Byers SW, et al. Single-cell transcriptomic analysis of tumor-derived fibroblasts and normal tissue-resident fibroblasts reveals fibroblast heterogeneity in breast cancer. Cancers. 2020;12:1307.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng X, Lai H, Luo W, Zhang M, Miao J, Song W, et al. Single-cell analysis reveals urothelial cell heterogeneity and regenerative cues following cyclophosphamide-induced bladder injury. Cell Death Dis. 2021;12:446.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simone D, Penkava F, Ridley A, Sansom S, Al-Mossawi MH, Bowness P. Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates. Commun Biol. 2021;4:1395.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao W, Chen Y, Li Z, Ji J, You A, Jin S, et al. Single cell RNA sequencing identifies a unique inflammatory macrophage subset as a druggable target for alleviating acute kidney injury. Adv Sci. 2022;9:e2103675.

Article  Google Scholar 

Zheng W, Wang X, Liu J, Yu X, Li L, Wang H, et al. Single-cell analyses highlight the proinflammatory contribution of C1q-high monocytes to Behçet’s disease. Proc Natl Acad Sci USA. 2022;119:e2204289119.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bassez A, Vos H, Van Dyck L, Floris G, Arijs I, Desmedt C, et al. A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer. Nat Med. 2021;27:820–32.

Article  CAS  PubMed  Google Scholar 

MacParland SA, Liu JC, Ma XZ, Innes BT, Bartczak AM, Gage BK, et al. Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations. Nat Commun. 2018;9:4383.

Article  PubMed  PubMed Central  Google Scholar 

Cao J, Spielmann M, Qiu X, Huang X, Ibrahim DM, Hill AJ, et al. The single-cell transcriptional landscape of mammalian organogenesis. Nature. 2019;566:496–502.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gulati GS, Sikandar SS, Wesche DJ, Manjunath A, Bharadwaj A, Berger MJ, et al. Single-cell transcriptional diversity is a hallmark of developmental potential. Science. 2020;367:405–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan CH, et al. Inference and analysis of cell-cell communication using CellChat. Nat Commun. 2021;12:1088.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin J, Cai Y, Wang Z, Ma Y, Pan J, Liu Y, et al. Novel biomarkers predict prognosis and drug-induced neuroendocrine differentiation in patients with prostate cancer. Front Endocrinol. 2022;13:1005916.

Article  Google Scholar 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102:15545–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. Omics. 2012;16:284–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lorenzo P, Bayliss MT, Heinegård D. A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age. J Biol Chem. 1998;273:23463–8.

Article  CAS  PubMed  Google Scholar 

Johnson K, Farley D, Hu SI, Terkeltaub R. One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. Arthritis Rheum. 2003;48:1302–14.

Article  CAS  PubMed  Google Scholar 

Luecken MD, Zaragosi LE, Madissoon E, Sikkema L, Firsova AB, De Domenico E, et al. The discovAIR project: a roadmap towards the Human Lung Cell Atlas. Eur Respir J. 2022;60:2102057.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yim A, Smith C, Brown AM. Osteopontin/secreted phosphoprotein-1 harnesses glial-, immune-, and neuronal cell ligand-receptor interactions to sense and regulate acute and chronic neuroinflammation. Immunol Rev. 2022;311:224–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bouleftour W, Juignet L, Bouet G, Granito RN, Vanden-Bossche A, Laroche N, et al. The role of the SIBLING, Bone Sialoprotein in skeletal biology - Contribution of mouse experimental genetics. Matrix Biol. 2016;52-54:60–77.

Article  CAS  PubMed  Google Scholar 

Whyte MP, Amalnath SD, McAlister WH, McKee MD, Veis DJ, Huskey M, et al. Hypophosphatemic osteosclerosis, hyperostosis, and enthesopathy associated with novel homozygous mutations of DMP1 encoding dentin matrix protein 1 and SPP1 encoding osteopontin: The first digenic SIBLING protein osteopathy? Bone. 202