American Cancer Society. Cancer Facts & Figures 2023. Atlanta, Ga: American Cancer Society; 2022. In: Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA, editors. SEER Cancer Statistics Review, 1975-2014, National Cancer Institute. Bethesda, MD

Daneshmand S, Bartsch G. Improving selection of appropriate urinary diversion following radical cystectomy for bladder cancer. Expert Rev Anticancer Ther. 2011;11(6):941–8.

Article  PubMed  Google Scholar 

Philip J, Manikandan R, Venugopal S, et al. Orthotopic neobladder versus ileal conduit urinary diversion after cystectomy–a quality-of-life based comparison. Ann R Coll Surg Engl. 2009;91(7):565–9.

Article  PubMed  PubMed Central  Google Scholar 

Large MC, Malik R, Cohn JA, Richards KA, Ganshert C, Kunnavakkum R, Smith ND, Steinberg GD. Prospective health-related quality of life analysis for patients undergoing radical cystectomy and urinary diversion. Urology. 2014;84(4):808–13.

Article  PubMed  Google Scholar 

Hautmann RE, Volkmer BG, Schumacher MC, Gschwend JE, Studer UE. Long-term results of standard procedures in urology: the ileal neobladder. World J Urol. 2006;24(3):305–14.

Article  PubMed  Google Scholar 

Steers WD. Voiding dysfunction in the orthotopic neobladder. World J Urol. 2000;18(5):330–7.

Article  CAS  PubMed  Google Scholar 

O’Connor RC, Kuznetsov DD, Patel RV, Galocy RM, Steinberg GD, Bales GT. Artificial urinary sphincter placement in men after cystectomy with orthotopic ileal neobladder: continence, complications, and quality of life. Urology. 2002;59(4):542–5.

Article  PubMed  Google Scholar 

LeDuc A, Camey M, Teillac P. An original antireflux ureteroileal implantation technique: long term follow up. J Urol. 1987;137:1156–8.

Article  CAS  Google Scholar 

Camey M. Bladder replacement by ileocystoplasty following radical cystectomy. Semin Urol. 1987;5(1):8–14.

CAS  PubMed  Google Scholar 

Sood R, Sharma GP, Gupta NP. The ileal neobladder–an ideal bladder substitute? Med J Armed Forces India. 1996;52(2):67–70.

Article  PubMed  PubMed Central  Google Scholar 

Lee KS, Montie JE, Dunn RL, Lee CT. Hautmann and Studer orthotopic neobladders: a contemporary experience. J Urol. 2003;169(6):2188–91.

Article  PubMed  Google Scholar 

Kim KH, Yoon HS, Song W, Choo HJ, Yoon H, Chung WS, Sim BS, Lee DH. Cluster analysis identifies three urodynamic patterns in patients with orthotopic neobladder reconstruction. PLoS ONE. 2017;12(10): e0185255.

Article  PubMed  PubMed Central  Google Scholar 

Obara W, Isurugi K, Kudo D, Takata R, Kato K, Kanehira M, Iwasaki K, Tanji S, Konda R, Fujioka T. Eight year experience with Studer ileal neobladder. Jpn J Clin Oncol. 2006;36(7):418–24.

Article  PubMed  Google Scholar 

Burgio KL, Goode PS, Locher JL, Umlauf MG, Roth DL, Richter HE, Varner RE, Lloyd LK. Behavioral training with and without biofeedback in the treatment of urge incontinence in older women: a randomized controlled trial. JAMA. 2002;288(18):2293–9.

Article  PubMed  Google Scholar 

Hashim H, Al MR. Management of fluid intake in patients with overactive bladder. Curr Urol Rep. 2009;10(6):428–33.

Article  PubMed  Google Scholar 

Madhuvrata P, Cody JD, Ellis G, Herbison GP, Hay-Smith EJ. Which anticholinergic drug for overactive bladder symptoms in adults. Cochrane Database Syst Rev. 2012;1:CD005429.

PubMed  Google Scholar 

Finney SM, Andersson KE, Gillespie JI, Stewart LH. Antimuscarinic drugs in detrusor overactivity and the overactive bladder syndrome: motor or sensory actions? BJU Int. 2006;98(3):503–7.

Article  CAS  PubMed  Google Scholar 

• El-Bahnasawy MS, Shaaban H, Gomha MA, Nabeeh A. Clinical and urodynamic efficacy of oxybutynin and verapamil in the treatment of nocturnal enuresis after formation of orthotopic ileal neobladders. A prospective, randomized, crossover study. Scand J Urol Nephrol. 2008;42(4):344–51. Retrospective study evaluating the efficacy of oxybutynin/verapamil in the management of neobladder incontinence.

• Zahran MH, Harraz AM, Taha DE, Nabeih H, El Hefnawy AS, Ali-El-Dein B. The short-term effects of tolterodine on nocturnal incontinence after orthotopic ileal neobladder: a randomized crossover placebo-controlled study. BJU Int. 2019. Retrospective study evaluating the efficacy of tolterodine in neobladder incontinence.

Fowler JE Jr, Clayton M, Mouli K, Reagan G. Effect of liquid diphenoxylate hydrochloride and atropine sulfate (lomotil) instillations on dynamics and function of continent cecal urinary reservoirs. J Urol. 1987;138(4):735–8.

Article  PubMed  Google Scholar 

• Hashem A, Abol-Enein H, Laymon M, Abdellutif MM, Ramez M, Taha MT, El-Hefnawy AS, Mosbah A. A randomized trial to examine the utility of mebeverine on the early return of continence following orthotopic bladder substitution. J Urol. 2021;205(5):1400–1406. Randomized trial assessing the utility of mebeverine in incontinent males less than 1 year following neobladder surgery.

Devinder Singh Bansi, John Louis-Auguste. Clinical Pharmacology (Eleventh Edition), Churchill Livingstone, Chapter 33 – Intestines. 2012, Pages 536–545

• Hashem A, Abdellutif MM, Laymon M, Abdullateef M, Abdelhamid A, Mosbah A, Abol-Enein H. Clinical efficacy of mebeverine for persistent nocturnal enuresis after orthotopic W-neobladder. BJU Int. 2022;129(3):387–393. Retrospective study evaluating the efficacy of mebeverine in nocturnal incontinence in neobladder patients.

Daniluk J, Malecka-Wojciesko E, Skrzydlo-Radomanska B, Rydzewska G. The efficacy of mebeverine in the treatment of irritable bowel syndrome-a systematic review. J Clin Med. 2022;11(4):1044.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Orasanu B, Mahajan ST. The use of botulinum toxin for the treatment of overactive bladder syndrome. Indian J Urol. 2013;29(1):2–11.

Article  PubMed  PubMed Central  Google Scholar 

• Hoag N, Tse V, Wang A, Chung E, Gani J. Intravesical onabotulinumtoxinA injection for overactive orthotopic ileal neobladder: feasibility and efficacy. Int Neurourol J. 2016;20(1):81–5. Case reports evaluating efficacy of intravesical onabotulinumtoxinA for OAB in orthotopic neobladder patients.

Toia B, Pakzad MH, Hamid R, Wood DN, Greenwell TJ, Ockrim JL. The efficacy of onabotulinumtoxinA in patients with previous failed augmentation cystoplasty: cohort series and literature review. Neurourol Urodynam. 2020;39(6):1831–6.

Article  CAS  Google Scholar 

Martinez L, Tubre R, Roberts R, Boone T, Griebling TL, Padmanabhan P, Khavari R. Refractory bladder dysfunction: a multi-institutional experience with intravesical botulinum toxin-a injection in adult patients who underwent previous augmentation cystoplasty. Turk J Urol. 2020;46(4):309–13.

Article  PubMed  PubMed Central  Google Scholar 

Miyake H, Hara S, Eto H, Arakawa S, Kamidono S, Hara I. Significance of renal function in changes in acid-base metabolism after orthotopic bladder replacement: colon neobladder compared with ileal neobladder. Int J Urol. 2004;11:83–7.

Article  PubMed  Google Scholar