Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7–34.

Article  PubMed  Google Scholar 

Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7–33.

Article  PubMed  Google Scholar 

Yang Q, Zhu L, Ye M, Zhang B, Zhan P, Li H, et al. Tumor suppressor 4.1N/EPB41L1 is epigenetic silenced by promoter methylation and MiR-454-3p in NSCLC. Front Genet. 2022;13:805960.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kapeleris J, Ebrahimi Warkiani M, Kulasinghe A, Vela I, Kenny L, Ladwa R, et al. Clinical applications of circulating tumour cells and circulating tumour DNA in non-small cell lung cancer-an update. Front Oncol. 2022;12:859152.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin HC, Li J, Cheng DD, Zhang X, Yu T, Zhao FY, et al. Nuclear export protein CSE1L interacts with P65 and promotes NSCLC growth via NF-kappaB/MAPK pathway. Mol Ther Oncolytics. 2021;21:23–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hashemi M, Mirzaei S, Zandieh MA, Rezaei S, Amirabbas K, Dehghanpour A, et al. Long non-coding RNAs (lncRNAs) in hepatocellular carcinoma progression: Biological functions and new therapeutic targets. Prog Biophys Mol Biol. 2022;177:207–28.

Article  PubMed  Google Scholar 

Li L, Wei H, Zhang YW, Zhao S, Che G, Wang Y, et al. Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors. Aging. 2021;13:23842–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu CN, Zhang HY, Liu CL, Wang CC. Upregulation of lncRNA CALML3-AS1 promotes cell proliferation and metastasis in cervical cancer via activation of the Wnt/beta-catenin pathway. Eur Rev Med Pharm Sci. 2019;23:5611–20.

Google Scholar 

Wang F, Zu Y, Huang W, Chen H, Xie H, Yang Y. LncRNA CALML3-AS1 promotes tumorigenesis of bladder cancer via regulating ZBTB2 by suppression of microRNA-4316. Biochem Biophys Res Commun. 2018;504:171–6.

Article  CAS  PubMed  Google Scholar 

Sun T, Wu R, Ming L. The role of m6A RNA methylation in cancer. Biomed Pharmacother. 2019;112:108613.

Article  CAS  PubMed  Google Scholar 

Zhang W, Qian Y, Jia G. The detection and functions of RNA modification m(6)A based on m(6)A writers and erasers. J Biol Chem. 2021;297:100973.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013;49:18–29.

Article  CAS  PubMed  Google Scholar 

Cao G, Li HB, Yin Z, Flavell RA. Recent advances in dynamic m6A RNA modification. Open Biol. 2016;6:160003.

Article  PubMed  PubMed Central  Google Scholar 

Ma L, Chen T, Zhang X, Miao Y, Tian X, Yu K, et al. The m(6)A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function. Redox Biol. 2021;38:101801.

Article  CAS  PubMed  Google Scholar 

Ma L, Zhang X, Yu K, Xu X, Chen T, Shi Y, et al. Targeting SLC3A2 subunit of system X(C)(-) is essential for m(6)A reader YTHDC2 to be an endogenous ferroptosis inducer in lung adenocarcinoma. Free Radic Biol Med. 2021;168:25–43.

Article  CAS  PubMed  Google Scholar 

Chen S, Zhou L, Wang Y. ALKBH5-mediated m(6)A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma. Cancer Cell Int. 2020;20:34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo X, Li K, Jiang W, Hu Y, Xiao W, Huang Y, et al. RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner. Mol Cancer. 2020;19:91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma W, Liang J, Mo J, Zhang S, Hu N, Tian D, et al. Butyrophilin-like 9 expression is associated with outcome in lung adenocarcinoma. BMC Cancer. 2021;21:1096.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koczor CA, Lee EK, Torres RA, Boyd A, Vega JD, Uppal K, et al. Detection of differentially methylated gene promoters in failing and nonfailing human left ventricle myocardium using computation analysis. Physiol Genomics. 2013;45:597–605.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Yang L, Liu X, Liu L, Liu M, Feng X, et al. lncRNA HOTTIP recruits EZH2 to inhibit PTEN expression and participates in IM resistance in chronic myeloid leukemia. Stem Cells Int. 2022;2022:9993393.

Article  PubMed  PubMed Central  Google Scholar 

Mori K, Inoue N, Fujishiro K, Hori H, Tanaka I. Effects of chronic inhalation of ethylene oxide on the rat testes. J UOEH. 1988;10:427–31.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Tang B, Song J, Yu S, Li Y, Su H, et al. Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression. J Exp Clin Cancer Res. 2019;38:92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xing CY, Zhang YZ, Hu W, Zhao LY. LINC00313 facilitates osteosarcoma carcinogenesis and metastasis through enhancing EZH2 mRNA stability and EZH2-mediated silence of PTEN expression. Cell Mol Life Sci. 2022;79:382.

Article  CAS  PubMed  Google Scholar 

Hu X, Tang J, Bao P, Deng W, Wu J, Liang Y, et al. Silencing of long non-coding RNA HOTTIP reduces inflammation in rheumatoid arthritis by demethylation of SFRP1. Mol Ther Nucleic Acids. 2020;19:468–81.

Article  CAS  PubMed  Google Scholar 

Liu Z, Wang T, She Y, Wu K, Gu S, Li L, et al. N(6)-methyladenosine-modified circIGF2BP3 inhibits CD8(+) T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. Mol Cancer. 2021;20:105.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175–91.

Article  PubMed  Google Scholar 

Ginn L, Shi L, Montagna M, Garofalo M. LncRNAs in non-small-cell lung cancer. Noncoding RNA. 2020;6:25.

PubMed  PubMed Central  Google Scholar 

Wang T, Kong S, Tao M, Ju S. The potential role of RNA N6-methyladenosine in cancer progression. Mol Cancer. 2020;19:88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bao J, Zhang C, Chen J, Xuan H, Wang C, Wang S, et al. LncRNA JPX targets SERCA2a to mitigate myocardial ischemia/reperfusion injury by binding to EZH2. Exp Cell Res. 2023;427:113572.

Article  CAS  PubMed  Google Scholar 

Hu Q, Ma H, Chen H, Zhang Z, Xue Q. LncRNA in tumorigenesis of non-small-cell lung cancer: from bench to bedside. Cell Death Discov. 2022;8:359.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen W, Pu J, Zuo Z, Gu S, Sun J, Tan B, et al. The RNA demethylase ALKBH5 promotes the progression and angiogenesis of lung cancer by regulating the stability of the LncRNA PVT1. Cancer Cell Int. 2022;22:353.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsuchiya K, Yoshimura K, Iwashita Y, Inoue Y, Ohta T, Watanabe H, et al. m(6)A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancer. Cancer Gene Ther. 2022;29:1355–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liao S, Sun H, Xu C. YTH Domain: a family of N(6)-methyladenosine (m(6)A) readers. Genomics Proteom Bioinforma. 2018;16:99–107.

Article  CAS  Google Scholar 

Melandri D, Zlatareva I, Chaleil RAG, Dart RJ, Chancellor A, Nussbaumer O, et al. The gammadeltaTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness. Nat Immunol. 2018;19:1352–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mo Q, Xu K, Luo C, Zhang Q, Wang L, Ren G. BTNL9 is frequently downregulated and inhibits proliferation and metastasis via the P53/CDC25C and P53/GADD45 pathways in breast cancer. Biochem Biophys Res Commun. 2021;553:17–24.

Article  CAS  PubMed