Interstitial Cystitis/Bladder Pain Syndrome: Role of Bladder Inflammation in Bladder Function

Jhang J-F, Jiang Y-H, Kuo H-C. Current understanding of the pathophysiology and novel treatments of interstitial cystitis/bladder pain syndrome. Biomedicines. 2022;10(10):2380.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Homma Y, Akiyama Y, Tomoe H, Furuta A, Ueda T, Maeda D, et al. Clinical guidelines for interstitial cystitis/bladder pain syndrome. Int J Urol. 2020;27(7):578–89.

Article  PubMed  Google Scholar 

Doggweiler R, Whitmore KE, Meijlink JM, Drake MJ, Frawley H, Nordling J, et al. A standard for terminology in chronic pelvic pain syndromes: a report from the chronic pelvic pain working group of the international continence society. Neurourol Urodyn. 2017;36(4):984–1008.

Article  PubMed  Google Scholar 

Lovick TA. Central control of visceral pain and urinary tract function. Auton Neurosci. 2016;200:35–42.

Article  PubMed  Google Scholar 

Kanter G, Komesu YM, Qaedan F, Jeppson PC, Dunivan GC, Cichowski SB, et al. Mindfulness-based stress reduction as a novel treatment for interstitial cystitis/bladder pain syndrome: a randomized controlled trial. Int Urogynecol J. 2016;27(11):1705–11.

Article  PubMed  PubMed Central  Google Scholar 

Malde S, Palmisani S, Al-Kaisy A, Sahai A. Guideline of guidelines: bladder pain syndrome. BJU Int. 2018;122(5):729–43.

Article  PubMed  Google Scholar 

Erickson DR, Tomaszewski JE, Kunselman AR, Bentley CM, Peters KM, Rovner ES, et al. Do the National Institute of Diabetes and Digestive and Kidney Diseases cystoscopic criteria associate with other clinical and objective features of interstitial cystitis? J Urol. 2005;173(1):93–7.

Article  PubMed  Google Scholar 

Birder LA. Pathophysiology of interstitial cystitis. Int J Urol. 2019;26(Suppl 1):12–5.

Article  PubMed  Google Scholar 

Clemens JQ, Erickson DR, Varela NP, Lai HH. Diagnosis and treatment of interstitial cystitis/bladder pain syndrome. J Urol. 2022;208(1):34–42.

Article  PubMed  Google Scholar 

Jiang YH, Peng CH, Liu HT, Kuo HC. Increased pro-inflammatory cytokines, C-reactive protein and nerve growth factor expressions in serum of patients with interstitial cystitis/bladder pain syndrome. PLoS ONE. 2013;8(10):e76779.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Homma Y, Nomiya A, Tagaya M, Oyama T, Takagaki K, Nishimatsu H, et al. Increased mRNA expression of genes involved in pronociceptive inflammatory reactions in bladder tissue of interstitial cystitis. J Urol. 2013;190(5):1925–31.

Article  CAS  PubMed  Google Scholar 

Maeda D, Akiyama Y, Morikawa T, Kunita A, Ota Y, Katoh H, et al. Hunner-type (classic) interstitial cystitis: a distinct inflammatory disorder characterized by pancystitis, with frequent expansion of clonal B-cells and epithelial denudation. PLoS ONE. 2015;10(11):e0143316.

Article  PubMed  PubMed Central  Google Scholar 

Hurst RE, Moldwin RM, Mulholland SG. Bladder defense molecules, urothelial differentiation, urinary biomarkers, and interstitial cystitis. Urology. 2007;69(4 Suppl):17–23.

Article  PubMed  Google Scholar 

Lin HY, Lu JH, Chuang SM, Chueh KS, Juan TJ, Liu YC, et al. Urinary biomarkers in interstitial cystitis/bladder pain syndrome and its impact on therapeutic outcome. Diagnostics. 2021;12(1):75.

Article  PubMed  PubMed Central  Google Scholar 

Elbadawi AE, Light JK. Distinctive ultrastructural pathology of nonulcerative interstitial cystitis: new observations and their potential significance in pathogenesis. Urol Int. 1996;56(3):137–62.

Article  CAS  PubMed  Google Scholar 

Tomaszewski JE, Landis JR, Russack V, Williams TM, Wang LP, Hardy C, et al. Biopsy features are associated with primary symptoms in interstitial cystitis: results from the interstitial cystitis database study. Urology. 2001;57(6 Suppl 1):67–81.

Article  CAS  PubMed  Google Scholar 

Gevaert T, De Vos R, Everaerts W, Libbrecht L, Van Der Aa F, van den Oord J, et al. Characterization of upper lamina propria interstitial cells in bladders from patients with neurogenic detrusor overactivity and bladder pain syndrome. J Cell Mol Med. 2011;15(12):2586–93.

Article  PubMed  PubMed Central  Google Scholar 

Shie JH, Liu HT, Kuo HC. Increased cell apoptosis of urothelium mediated by inflammation in interstitial cystitis/painful bladder syndrome. Urology. 2012;79(2):484.e7-13.

Article  PubMed  Google Scholar 

Nickel JC, Tripp DA. International Interstitial Cystitis Study G. Clinical and psychological parameters associated with pain pattern phenotypes in women with interstitial cystitis/bladder pain syndrome. J Urol. 2015;193(1):138–44.

Article  PubMed  Google Scholar 

Keller JJ, Chen Y-K, Lin H-C. Comorbidities of bladder pain syndrome/interstitial cystitis: a population-based study. BJU Int. 2012;110(11c):E903–9.

Article  PubMed  Google Scholar 

Fuoco MB, Irvine-Bird K, Curtis NJ. Multiple sensitivity phenotype in interstitial cystitis/bladder pain syndrome. Can Urol Assoc J. 2014;8(11–12):E758–61.

Article  PubMed  PubMed Central  Google Scholar 

Clemens JQ, Elliott MN, Suttorp M, Berry SH. Temporal ordering of interstitial cystitis/bladder pain syndrome and non-bladder conditions. Urology. 2012;80(6):1227–31.

Article  PubMed  Google Scholar 

Jhang JF, Hsu YH, Kuo HC. Urothelial functional protein and sensory receptors in patients with interstitial cystitis/bladder pain syndrome with and without Hunner’s lesion. Urology. 2016;98:44–9.

Article  PubMed  Google Scholar 

Birder L, Andersson KE. Urothelial signaling. Physiol Rev. 2013;93(2):653–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akiyama Y, Homma Y, Maeda D. Pathology and terminology of interstitial cystitis/bladder pain syndrome: a review. Histol Histopathol. 2019;34(1):25–32.

CAS  PubMed  Google Scholar 

Sant GR, Kempuraj D, Marchand JE, Theoharides TC. The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis. Urology. 2007;69(4 Suppl):34–40.

Article  PubMed  Google Scholar 

Hanno P, Lin A, Nordling J, Nyberg L, van Ophoven A, Ueda T, et al. Bladder pain syndrome committee of the international consultation on incontinence. Neurourol Urodyn. 2010;29(1):191–8.

Article  PubMed  Google Scholar 

Hauser PJ, Dozmorov MG, Bane BL, Slobodov G, Culkin DJ, Hurst RE. Abnormal expression of differentiation related proteins and proteoglycan core proteins in the urothelium of patients with interstitial cystitis. J Urol. 2008;179(2):764–9.

Article  CAS  PubMed  Google Scholar 

Janssen DA, van Wijk XM, Jansen KC, van Kuppevelt TH, Heesakkers JP, Schalken JA. The distribution and function of chondroitin sulfate and other sulfated glycosaminoglycans in the human bladder and their contribution to the protective bladder barrier. J Urol. 2013;189(1):336–42.

Article  CAS  PubMed  Google Scholar 

Shie JH, Kuo HC. Higher levels of cell apoptosis and abnormal E-cadherin expression in the urothelium are associated with inflammation in patients with interstitial cystitis/painful bladder syndrome. BJU Int. 2011;108(2 Pt 2):E136–41.

PubMed  Google Scholar 

Liu HT, Shie JH, Chen SH, Wang YS, Kuo HC. Differences in mast cell infiltration, E-cadherin, and zonula occludens-1 expression between patients with overactive bladder and interstitial cystitis/bladder pain syndrome. Urology. 2012;80(1):225.e13-8.

Article  PubMed  Google Scholar 

D’Amico R, Trovato Salinaro A, Cordaro M, Fusco R, Impellizzeri D, Interdonato L, et al. Hidrox((R)) and chronic cystitis: biochemical evaluation of inflammation, oxidative stress, and pain. Antioxidants. 2021;10(7):1046.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karantza V. Keratins in health and cancer: more than mere epithelial cell markers. Oncogene. 2011;30(2):127–38.

Article  CAS  PubMed  Google Scholar 

Laguna P, Smedts F, Nordling J, Horn T, Bouchelouche K, Hopman A, et al. Keratin expression profiling of transitional epithelium in the painful bladder syndrome/interstitial cystitis. Am J Clin Pathol. 2006;125(1):105–10.

Article  PubMed  Google Scholar 

Vaidyanathan S, McDicken IW, Ikin AJ, Mansour P, Soni BM, Singh G, et al. A study of cytokeratin 20 immunostaining in the urothelium of neuropathic bladder of patients with spinal cord injury. BMC Urol. 2002;2(1):7.

Article  PubMed  PubMed Central  Google Scholar 

Jhang JF, Jiang YH, Hsu YH, Ho HC, Kuo HC. Decreased urothelial cytoskeleton and cell proliferation protein expression suggest interstitial cystitis/bladder pain syndrome patients with Hunner’s lesion and grade 3 glomerulation might be different from other types of patients. Int J Urol. 2021;28(8):823–30.

Article  CAS  PubMed  Google Scholar 

Deckmann K, Filipski K, Krasteva-Christ G, Fronius M, Althaus M, Rafiq A, et al. Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes. Proc Natl Acad Sci U S A. 2014;111(22):8287–92.

Article  CAS  PubMed  PubMed Central  Googl

留言 (0)

沒有登入
gif