Kalia, R. & Frost, A. Open and cut: allosteric motion and membrane fission by dynamin superfamily proteins. Mol. Biol. Cell 30, 2097–2104 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pfitzner, A. K., von Filseck, J. M. & Roux, A. Principles of membrane remodeling by dynamic ESCRT-III polymers. Trends Cell Biol. 31, 856–868 (2021).

Article  CAS  PubMed  Google Scholar 

Westermann, B. Mitochondrial fusion and fission in cell life and death. Nat. Rev. Mol. Cell Biol. 11, 872–884 (2010).

Article  CAS  PubMed  Google Scholar 

Harrison, S. C. Viral membrane fusion. Virology 479, 498–507 (2015).

Article  PubMed  Google Scholar 

White, J. M., Ward., A.E., Odongo, L. & Tamm, L.K. Viral membrane fusion: a dance between proteins and lipids. Annu. Rev. Virol. 10, https://doi.org/10.1146/annurev-virology-111821-093413 (2023).

Söllner, T. et al. SNAP receptors implicated in vesicle targeting and fusion. Nature 362, 318–324 (1993).

Article  PubMed  Google Scholar 

Südhof, T. C. & Rothman, J. E. Membrane fusion: grappling with SNARE and SM proteins. Science 323, 474–477 (2009).

Article  PubMed  PubMed Central  Google Scholar 

Südhof, T. C. The synaptic vesicle cycle. Annu. Rev. Neurosci. 27, 509–547 (2004).

Article  PubMed  Google Scholar 

Schillemans, M., Karampini, E., Kat, M. & Bierings, R. Exocytosis of Weibel–Palade bodies: how to unpack a vascular emergency kit. J. Thromb. Haemost. 17, 6–18 (2019).

Article  CAS  PubMed  Google Scholar 

Jahn, R. & Scheller, R. H. SNAREs—engines for membrane fusion. Nat. Rev. Mol. Cell Biol. 7, 631–643 (2006).

Article  CAS  PubMed  Google Scholar 

Brukman, N. G., Uygur, B., Podbilewicz, B. & Chernomordik, L. V. How cells fuse. J. Cell Biol. 218, 1436–1451 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petrany, M. J. & Millay, D. P. Cell fusion: merging membranes and making muscle. Trends Cell Biol. 29, 964–973 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao, S. & Hu, J. Mitochondrial fusion: the machineries in and out. Trends Cell Biol. 31, 62–74 (2021).

Article  CAS  PubMed  Google Scholar 

Wickner, W. & Rizo, J. A cascade of multiple proteins and lipids catalyzes membrane fusion. Mol. Biol. Cell 28, 707–711 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, Y. & Hughson, F. M. Chaperoning SNARE folding and assembly. Annu. Rev. Biochem. 90, 581–603 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rizo, J. Molecular mechanisms underlying neurotransmitter release. Annu. Rev. Biophys. 51, 377–408 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Brunger, A. T., Choi, U. B., Lai, Y., Leitz, J. & Zhou, Q. Molecular mechanisms of fast neurotransmitter release. Annu. Rev. Biophys. 47, 469–497 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bubnis, G. & Grubmüller, H. Sequential water and headgroup merger: membrane poration paths and energetics from MD simulations. Biophys. J. 119, 2418–2430 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smirnova, Y. G., Risselada, H. J. & Müller, M. Thermodynamically reversible paths of the first fusion intermediate reveal an important role for membrane anchors of fusion proteins. Proc. Natl Acad. Sci. USA 116, 2571–2576 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kozlov, M. M. & Markin, V. S. Possible mechanism of membrane fusion [Russian]. Biofizika 28, 242–247 (1983).

CAS  PubMed  Google Scholar 

Kuzmin, P. I., Zimmerberg, J., Chizmadzhev, Y. A. & Cohen, F. S. A quantitative model for membrane fusion based on low-energy intermediates. Proc. Natl Acad. Sci. USA 98, 7235–7240 (2001).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kozlov, M. M. & Chernomordik, L. V. Membrane tension and membrane fusion. Curr. Opin. Struct. Biol. 33, 61–67 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chernomordik, L. V. & Kozlov, M. M. Protein–lipid interplay in fusion and fission of biological membranes. Annu. Rev. Biochem 72, 175–207 (2003).

Article  CAS  PubMed  Google Scholar 

Cohen, F. S. & Melikyan, G. B. The energetics of membrane fusion from binding, through hemifusion, pore formation, and pore enlargement. J. Membr. Biol. 199, 1–14 (2004).

Article  CAS  PubMed  Google Scholar 

Fan, Z. A., Tsang, K. Y., Chen, S. H. & Chen, Y. F. Revisit the correlation between the elastic mechanics and fusion of lipid membranes. Sci. Rep. 6, 31470 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chernomordik, L. V. & Kozlov, M. M. Mechanics of membrane fusion. Nat. Struct. Mol. Biol. 15, 675–683 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marrink, S. J. & Mark, A. E. The mechanism of vesicle fusion as revealed by molecular dynamics simulations. J. Am. Chem. Soc. 125, 11144–11145 (2003).

Article  CAS  PubMed  Google Scholar 

Beaven, A. H., Sapp, K. & Sodt, A. J. Simulated dynamic cholesterol redistribution favors membrane fusion pore constriction. Biophys. J. 122, 2162–2175 (2022).

Article  PubMed  Google Scholar 

Johner, N., Harries, D. & Khelashvili, G. Implementation of a methodology for determining elastic properties of lipid assemblies from molecular dynamics simulations. BMC Bioinform. 17, 161 (2016).

Article  Google Scholar 

Rice, A., Zimmerberg, J. & Pastor, R. W. Initiation and evolution of pores formed by influenza fusion peptides probed by lysolipid inclusion. Biophys. J. 122, 1018–1032 (2023).

Article  CAS  PubMed  Google Scholar 

Grafmuller, A., Shillcock, J. & Lipowsky, R. The fusion of membranes and vesicles: pathway and energy barriers from dissipative particle dynamics. Biophys. J. 96, 2658–2675 (2009).

Article  PubMed  PubMed Central  Google Scholar 

Kawamoto, S., Klein, M. L. & Shinoda, W. Coarse-grained molecular dynamics study of membrane fusion: curvature effects on free energy barriers along the stalk mechanism. J. Chem. Phys. 143, 243112 (2015).

Article  PubMed  Google Scholar 

McLaughlin, S. The electrostatic properties of membranes. Annu. Rev. Biophys. Biophys. Chem. 18, 113–136 (1989).

Article  CAS  PubMed  Google Scholar 

Lipowsky, R. The conformation of membranes. Nature 349, 475–481 (1991).

Article  CAS  PubMed  Google Scholar 

Rand, R. P. & Parsegian, V. A. Physical force considerations in model and biological membranes. Can. J. Biochem. Cell Biol. 62, 752–759 (1984).

Article  CAS  PubMed  Google Scholar 

Israelachvili, J. N. Surface forces. In The Handbook of Surface Imaging and Visualization (ed. Hubbard, A. T.) Ch. 24, 793–817 (Taylor & Francis, 1995).

Tamm, L. K. & Han, X. Viral fusion peptides: a tool set to disrupt and connect biological membranes. Biosci. Rep. 20, 501–518 (2000).

Article  CAS  PubMed  Google Scholar 

Risselada, H. J. et al. Line-tension controlled mechanism for influenza fusion. PLoS ONE 7, e38302 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langosch, D. et al. Peptide mimics of SNARE transmembrane segments drive membrane fusion depending on their conformational plasticity. J. Mol. Biol. 311, 709–721 (2001).

Article  CAS  PubMed  Google Scholar 

Hernandez, J. M., Kreutzberger, A. J. B., Kiessling, V., Ta