Dehydroepiandrosterone-induced polycystic ovary syndrome mouse model requires continous treatments to maintain reproductive phenotypes

Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol. 2011;7(4):219–31.

Article  CAS  PubMed  Google Scholar 

The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41–7.

Article  Google Scholar 

Teede H, Deeks A, Moran L. Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med. 2010;8(1):41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McCartney CR, Marshall JC. Polycystic Ovary Syndrome. Solomon CG, ed. N Engl J Med. 2016;375(1):54–64.

Article  PubMed  PubMed Central  Google Scholar 

Moran L, Teede H. Metabolic features of the reproductive phenotypes of polycystic ovary syndrome. Hum Reprod Update. 2009;15(4):477–88.

Article  CAS  PubMed  Google Scholar 

Dapas M, Dunaif A. Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification. Endocr Rev. 2022;43(6):927–65.

Article  PubMed  PubMed Central  Google Scholar 

Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol. 2013;6:1–13.

Article  PubMed  PubMed Central  Google Scholar 

Stener-Victorin E. Update on animal models of polycystic ovary syndrome. Endocrinology. 2022;163(12):bqac164.

Article  PubMed  PubMed Central  Google Scholar 

Caldwell ASL, Middleton LJ, Jimenez M, et al. Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models. Endocrinology. 2014;155(8):3146–59.

Article  CAS  PubMed  Google Scholar 

Mannerås L, Cajander S, Holmäng A, et al. A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome. Endocrinology. 2007;148(8):3781–91.

Article  PubMed  Google Scholar 

Bourgneuf C, Bailbé D, Lamazière A, et al. The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome. Nat Commun. 2021;12(1):1064.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Labrie F, Luu-The V, Bélanger A, et al. Is dehydroepiandrosterone a hormone? J Endocrinol. 2005;187(2):169–96.

Article  CAS  PubMed  Google Scholar 

Olaniyan OT, Bamidele O, Uche S, et al. Ovarian metabolic activity in dehydroepiandrosterone-induced polycystic ovary in wistar rats treated with aspirin. JBRA Assist Reprod. 2020;24(1):41–54.

PubMed  PubMed Central  Google Scholar 

Shen Q, Bi H, Yu F, et al. Nontargeted metabolomic analysis of skeletal muscle in a dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome. Mol Reprod Dev. 2019;86(4):370–8.

Article  CAS  PubMed  Google Scholar 

Wu G, Hu X, Ding J, Yang J. The effect of glutamine on dehydroepiandrosterone-induced polycystic ovary syndrome rats. J Ovarian Res. 2020;13(1):57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen HR, Xu X, Ye D, Li XL. Berberine improves the symptoms of DHEA-Induced PCOS rats by regulating gut microbiotas and metabolites. Gynecol Obstet Invest. 2021;86(4):388–97.

Article  CAS  PubMed  Google Scholar 

Zhang X, Zhang C, Shen S, et al. Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats. Hum Reprod. 2013;28(11):3074–85.

Article  CAS  PubMed  Google Scholar 

Li SY, Song Z, Song MJ, Qin JW, Zhao ML, Yang ZM. Impaired receptivity and decidualization in DHEA-induced PCOS mice. Sci Rep. 2016;6(1):38134.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dou L, Zheng Y, Li L, et al. The effect of cinnamon on polycystic ovary syndrome in a mouse model. Reprod Biol Endocrinol. 2018;16(1):99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Walters KA, Allan CM, Handelsman DJ. Rodent models for human polycystic ovary syndrome. Biol Reprod. 2012;86(5):1–12.

Article  Google Scholar 

Osuka S, Nakanishi N, Murase T, et al. Animal models of polycystic ovary syndrome: A review of hormone-induced rodent models focused on hypothalamus-pituitary-ovary axis and neuropeptides. Reprod Med Biol. 2019;18(2):151–60.

Article  PubMed  Google Scholar 

Lai H, Jia X, Yu Q, et al. High-fat diet induces significant metabolic disorders in a mouse model of polycystic ovary syndrome1. Biol Reprod. 2014;91(5):1–11.

Article  Google Scholar 

Azziz R, Sanchez LA, Knochenhauer ES, et al. Androgen excess in women: experience with over 1000 consecutive patients. J Clin Endocrinol Metab. 2004;89(2):453–62.

Article  CAS  PubMed  Google Scholar 

Azziz R, Carmina E, Dewailly D, et al. The androgen excess and PCOS society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril. 2009;91(2):456–88.

Article  PubMed  Google Scholar 

Poojary PS, Nayak G, Panchanan G, et al. Distinctions in pcos induced by letrozole Vs dehydroepiandrosterone with high-fat diet in mouse model. Endocrinology. 2022;163(9):bqac097.

Article  PubMed  Google Scholar 

Balen AH, Morley LC, Misso M, et al. The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance. Hum Reprod Update. 2016;22(6):687–708.

Article  PubMed  Google Scholar 

Boutzios G, Karalaki M, Zapanti E. Common pathophysiological mechanisms involved in luteal phase deficiency and polycystic ovary syndrome. Impact Ferti Endocrine. 2013;43(2):314–7.

CAS  Google Scholar 

Salehi M, Bravo-Vera R, Sheikh A, Gouller A, Poretsky L. Pathogenesis of polycystic ovary syndrome: what is the role of obesity? Metabolism. 2004;53(3):358–76.

Article  CAS  PubMed  Google Scholar 

Weiss EP, Villareal DT, Fontana L, Han DH, Holloszy JO. Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans. Aging. 2011;3(5):533–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tchernof A, Labrie F. Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies. Eur J Endocrinol. Published online July 1, 2004:1–14.

De Pergola G. The adipose tissue metabolism: role of testosterone and dehydroepiandrosterone. Int J Obes. 2000;24(S2):S59–63.

Article  Google Scholar 

Wang F, He Y, Santos HO, Sathian B, Price JC, Diao J. The effects of dehydroepiandrosterone (DHEA) supplementation on body composition and blood pressure: a meta-analysis of randomized clinical trials. Steroids. 2020;163:108710.

Article  CAS  PubMed  Google Scholar 

Lovejoy JC, Bray GA, Bourgeois MO, et al. Exogenous androgens influence body composition and regional body fat distribution in obese postmenopausal women–a clinical research center study. J Clin Endocrinol Metab. 1996;81(6):2198–203.

CAS  PubMed  Google Scholar 

Elbers JMH, Asscheman H, Seidell JC, Megens JAJ, Gooren LJG. Long-term testosterone administration increases visceral fat in female to male transsexuals1. J Clin Endocrinol Metab. 1997;82(7):2044–7.

CAS  PubMed  Google Scholar 

Liu S, Yao Q, Li X, et al. Effects of a ketogenic diet on reproductive and metabolic phenotypes in mice with polycystic ovary syndrome. Biol Reprod. 2023;108(4):597–610.

Article  PubMed  Google Scholar 

Xie Q, Xiong X, Xiao N, et al. Mesenchymal stem cells alleviate DHEA-induced polycystic ovary syndrome (PCOS) by Inhibiting Inflammation in Mice. Stem Cells Int. 2019;2019:e9782373.

Article  Google Scholar 

Jang M, Lee MJ, Lee JM, et al. Oriental Medicine Kyung-Ok-Ko prevents and alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats. PLoS ONE. 2014;9(2):e87623.

Article  PubMed  PubMed Central  Google Scholar 

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