Scrivo A, Bourdenx M, Pampliega O, Cuervo AM. Selective autophagy as a potential therapeutic target for neurodegenerative disorders. Lancet Neurol 2018, 17: 802–815.
Article PubMed PubMed Central Google Scholar
Mizushima N, Komatsu M. Autophagy: Renovation of cells and tissues. Cell 2011, 147: 728–741.
Article CAS PubMed Google Scholar
Mizushima N. A brief history of autophagy from cell biology to physiology and disease. Nat Cell Biol 2018, 20: 521–527.
Article CAS PubMed Google Scholar
Tooze SA, Dikic I. Autophagy captures the Nobel prize. Cell 2016, 167: 1433–1435.
Article CAS PubMed Google Scholar
Levine B, Klionsky DJ. Autophagy wins the 2016 Nobel Prize in Physiology or Medicine: Breakthroughs in baker’s yeast fuel advances in biomedical research. Proc Natl Acad Sci U S A 2017, 114: 201–205.
Article CAS PubMed Google Scholar
Levine B, Kroemer G. Biological functions of autophagy genes: A disease perspective. Cell 2019, 176: 11–42.
Article CAS PubMed PubMed Central Google Scholar
Galluzzi L, Bravo-San Pedro JM, Blomgren K, Kroemer G. Autophagy in acute brain injury. Nat Rev Neurosci 2016, 17: 467–484.
Article CAS PubMed Google Scholar
Peker N, Gozuacik D. Autophagy as a cellular stress response mechanism in the nervous system. J Mol Biol 2020, 432: 2560–2588.
Article CAS PubMed Google Scholar
Ren J, Taegtmeyer H. Too much or not enough of a good thing—The Janus faces of autophagy in cardiac fuel and protein homeostasis. J Mol Cell Cardiol 2015, 84: 223–226.
Article CAS PubMed Google Scholar
Button RW, Luo S, Rubinsztein DC. Autophagic activity in neuronal cell death. Neurosci Bull 2015, 31: 382–394.
Article PubMed PubMed Central Google Scholar
Bar-Yosef T, Damri O, Agam G. Dual role of autophagy in diseases of the central nervous system. Front Cell Neurosci 2019, 13: 196.
Article CAS PubMed PubMed Central Google Scholar
Djajadikerta A, Keshri S, Pavel M, Prestil R, Ryan L, Rubinsztein DC. Autophagy induction as a therapeutic strategy for neurodegenerative diseases. J Mol Biol 2020, 432: 2799–2821.
Article CAS PubMed Google Scholar
Kulkarni A, Chen J, Maday S. Neuronal autophagy and intercellular regulation of homeostasis in the brain. Curr Opin Neurobiol 2018, 51: 29–36.
Article CAS PubMed Google Scholar
Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 2010, 90: 1383–1435.
Article CAS PubMed Google Scholar
Nixon RA. The role of autophagy in neurodegenerative disease. Nat Med 2013, 19: 983–997.
Article CAS PubMed Google Scholar
Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 2004, 36: 585–595.
Article CAS PubMed Google Scholar
Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, et al. Small molecules enhance autophagy and reduce toxicity in Huntington’s disease models. Nat Chem Biol 2007, 3: 331–338.
Article CAS PubMed PubMed Central Google Scholar
Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, et al. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease. Nat Neurosci 2019, 22: 401–412.
Article CAS PubMed PubMed Central Google Scholar
Moreau K, Fleming A, Imarisio S, Lopez Ramirez A, Mercer JL, Jimenez-Sanchez M, et al. PICALM modulates autophagy activity and tau accumulation. Nat Commun 2014, 5: 4998.
Article CAS PubMed Google Scholar
Cragnaz L, Spinelli G, De Conti L, Bureau EA, Brownlees J, Feiguin F, et al. Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance. Neurobiol Dis 2021, 160: 105515.
Article CAS PubMed Google Scholar
Vasconcelos-Ferreira A, Martins IM, Lobo D, Pereira D, Lopes MM, Faro R, et al. ULK overexpression mitigates motor deficits and neuropathology in mouse models of Machado-Joseph disease. Mol Ther 2022, 30: 370–387.
Article CAS PubMed Google Scholar
Vasconcelos-Ferreira A, Carmo-Silva S, Codêsso JM, Silva P, Martinez ARM, França MC Jr, et al. The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado-Joseph disease. Neuropathol Appl Neurobiol 2022, 48: e12763.
Article CAS PubMed Google Scholar
Dazzo E, Nobile C. Epilepsy-causing Reelin mutations result in impaired secretion and intracellular degradation of mutant proteins. Hum Mol Genet 2022, 31: 665–673.
Article CAS PubMed Google Scholar
Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007, 131: 1149–1163.
Article CAS PubMed Google Scholar
Komatsu M, Wang QJ, Holstein GR, Friedrich VL Jr, Iwata JI, Kominami E, et al. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A 2007, 104: 14489–14494.
Article CAS PubMed PubMed Central Google Scholar
Komatsu M, Waguri S, Chiba T, Murata S, Iwata JI, Tanida I, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006, 441: 880–884.
Article CAS PubMed Google Scholar
Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006, 441: 885–889.
Article CAS PubMed Google Scholar
Glatigny M, Moriceau S, Rivagorda M, Ramos-Brossier M, Nascimbeni AC, Lante F, et al. Autophagy is required for memory formation and reverses age-related memory decline. Curr Biol 2019, 29: 435-448.e8.
Article CAS PubMed Google Scholar
la Barbera L, Vedele F, Nobili A, Krashia P, Spoleti E, Latagliata EC, et al. Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease. Prog Neurobiol 2021, 202: 102031.
Bordi M, Berg MJ, Mohan PS, Peterhoff CM, Alldred MJ, Che S, et al. Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy. Autophagy 2016, 12: 2467–2483.
Article CAS PubMed PubMed Central Google Scholar
Dong XX, Wang Y, Qin ZH. Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases. Acta Pharmacol Sin 2009, 30: 379–387.
Article CAS PubMed PubMed Central Google Scholar
Wang Y, Qin ZH. Molecular and cellular mechanisms of excitotoxic neuronal death. Apoptosis 2010, 15: 1382–1402.
Article CAS PubMed Google Scholar
Qin ZH, Wang Y, Nakai M, Chase TN. Nuclear factor-kappa B contributes to excitotoxin-induced apoptosis in rat striatum. Mol Pharmacol 1998, 53: 33–42.
Article CAS PubMed Google Scholar
Qin ZH, Wang Y, Chase TN. Stimulation of N-methyl-D-aspartate receptors induces apoptosis in rat brain. Brain Res 1996, 725: 166–176.
Qin ZH, Chen RW, Wang Y, Nakai M, Chuang DM, Chase TN. Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum. J Neurosci 1999, 19: 4023–4033.
Article CAS PubMed PubMed Central Google Scholar
Wang Y, Han R, Liang ZQ, Wu JC, Zhang XD, Gu ZL, et al. An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid. Autophagy 2008, 4: 214–226.
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