Catala M, Kubis N. Gross anatomy and development of the peripheral nervous system. Handb Clin Neurol 2013, 115: 29–41.

Article  PubMed  Google Scholar 

Pipis M, Rossor AM, Laura M, Reilly MM. Next-generation sequencing in Charcot-Marie-Tooth disease: Opportunities and challenges. Nat Rev Neurol 2019, 15: 644–656.

Article  PubMed  Google Scholar 

Froelich CA, First EA. Dominant intermediate Charcot-Marie-tooth disorder is not due to a catalytic defect in tyrosyl-tRNA synthetase. Biochemistry 2011, 50: 7132–7145.

Article  CAS  PubMed  Google Scholar 

Blocquel D, Li S, Wei N, Daub H, Sajish M, Erfurth ML. Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy. Nucleic Acids Res 2017, 45: 8091–8104.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matsuyama A, Shimazu T, Sumida Y, Saito A, Yoshimatsu Y, Seigneurin-Berny D, et al. In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J 2002, 21: 6820–6831.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saxena S, Caroni P. Selective neuronal vulnerability in neurodegenerative diseases: From stressor thresholds to degeneration. Neuron 2011, 71: 35–48.

Article  CAS  PubMed  Google Scholar 

Skoge RH, Dölle C, Ziegler M. Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels. DNA Repair (Amst) 2014, 23: 33–38.

Article  CAS  PubMed  Google Scholar 

North BJ, Marshall BL, Borra MT, Denu JM, Verdin E. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell 2003, 11: 437–444.

Article  CAS  PubMed  Google Scholar 

Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, et al. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson’s disease. Science 2007, 317: 516–519.

Article  CAS  PubMed  Google Scholar 

Luthi-Carter R, Taylor DM, Pallos J, Lambert E, Amore A, Parker A, et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A 2010, 107: 7927–7932.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Xie L, Shen C, Qi Q, Qin Y, Xing J, et al. SIRT2-knockdown rescues GARS-induced Charcot-Marie-tooth neuropathy. Aging Cell 2021, 20: e13391.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei N, Zhang Q, Yang XL. Neurodegenerative Charcot-Marie-Tooth disease as a case study to decipher novel functions of aminoacyl-tRNA synthetases. J Biol Chem 2019, 294: 5321–5339.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Storkebaum E, Leitão-Gonçalves R, Godenschwege T, Nangle L, Mejia M, Bosmans I, et al. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy. Proc Natl Acad Sci U S A 2009, 106: 11782–11787.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu Z, Schaedel L, Portran D, Aguilar A, Gaillard J, Xu Z, et al. Microtubules acquire resistance from mechanical breakage through intralumenal acetylation. Science 2017, 356: 328–332.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Godena VK, Brookes-Hocking N, Moller A, Shaw G, Oswald M, Sancho RM, et al. Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations. Nat Commun 2014, 5: 5245.

Article  CAS  PubMed  Google Scholar 

Bobrowska A, Donmez G, Weiss A, Guarente L, Bates G. SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington’s disease phenotypes in vivo. PLoS One 2012, 7: e34805.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li W, Zhang B, Tang J, Cao Q, Wu Y, Wu C, et al. Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin. J Neurosci 2007, 27: 2606–2616.

Article  PubMed  PubMed Central  Google Scholar 

Niu X, Mao CX, Wang S, Wang X, Zhang Y, Hu J, et al. α-Tubulin acetylation at lysine 40 regulates dendritic arborization and larval locomotion by promoting microtubule stability in Drosophila. PLoS One 2023, 18: e0280573.

Article  CAS  PubMed  PubMed Central  Google Scholar