The continued advancement of magnetic resonance (MR) imaging technology, combined with the increasing availability of the necessary equipment, has led to an expansion of treatment options for patients. These advances have also led to the growth of a previous niche area within interventional radiology. MR image guidance offers multiple benefits including high soft tissue contrast even in diminutive lesions, near real-time imaging, unconstrained applicator angulation across all planes enabling a precise positioning of a device, and the capacity to observe intervention-associated alterations in tissue properties during the intervention [1], [2], [3]. In certain fields, MRI has already established itself as a viable imaging method for interventions. For instance, MR-guidance is widely used in prostate interventions and MR-guided biopsy is an integral part of many breast imaging centers [4,5]. However, for certain applications such as percutaneous thermal ablation, the use of MRI for image guidance is not as prevalent, although the entire spectrum of advantages of MR-guided procedures can be applied for this kind of intervention. Therefore, the fundamentals of MR-guided interventions are outlined in detail based on percutaneous thermal ablation as an example. A comprehensive overview of the individual intervention steps, required equipment, periinterventional management, and clinical outcomes of MR-guided thermoablation is provided. We also briefly review percutaneous MR-guided biopsies. However, other MR-guided procedures, including MR-guided high-intensity focused ultrasound, joint injections, and MR-guided interventions for vascular, prostate, breast, and musculoskeletal conditions, are discussed elsewhere [4,[6], [7], [8], [9]].