Eesam S, Bhandaru JS, Akkinepally RR, Bobbala RK. Cocrystallization of gliclazide with improved physicochemical properties. Future J Pharm Sci. 2021;7(1). https://doi.org/10.1186/s43094-021-00261-z.

Thakuria R, Delori A, Jones W, Lipert MP, Roy L, Rodriguez-Hornedo N. Pharmaceutical cocrystals and poorly soluble drugs. Int J Pharm. 2013;453(1):101–25. https://doi.org/10.1016/j.ijpharm.2012.10.043.

Patole T. Co-Crystallization - A technique for solubility enhancement. Int J Pharm Sci Res. 5(9):3566–76. https://doi.org/10.13040/IJPSR.0975-8232.5(9).3566-76.

Al-Kazemi R, Al-Basarah Y, Nada A. Dissolution enhancement of atorvastatin calcium by cocrystallization. Adv Pharm Bull. 9(4):559–70. https://doi.org/10.15171/apb.2019.064.

Kumar S, Nanda A. Pharmaceutical cocrystals: An overview. Indian J Pharm Sci. 79(6). https://doi.org/10.4172/pharmaceutical-sciences.1000302.

Yuvaraja K, Khanam J. Enhancement of carvedilol solubility by solid dispersion technique using cyclodextrins, water soluble polymers and hydroxyl acid. J Pharm Biomed Anal. 2014;96:10–20. https://doi.org/10.1016/j.jpba.2014.03.019.

Jinno J, Kamada N, Miyake M, Yamada K, Mukai T, Odomi M, Toguchi H, Liversidge GG, Higaki K, Kimura T. Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in Beagle Dogs. J Control Release. 2006;111(1–2):56–64. https://doi.org/10.1016/j.jconrel.2005.11.013.

Singh S, Bhagel R, Yadav L. A review on solid dispersion. Int J Pharm Life Sci. 2011;2:1078–95.

CAS  Google Scholar 

Sethia S, Squillante E. Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methods. Int J Pharm. 2004;272(1–2):1–10. https://doi.org/10.1016/j.ijpharm.2003.11.025.

Article  CAS  PubMed  Google Scholar 

Li W, Qing S, Zhi W, Yao H, Fu C, Niu X. The pharmacokinetics and anti-inflammatory effects of chelerythrine solid dispersions in vivo. J Drug Deliv Sci Technol. 2017;40:51–8. https://doi.org/10.1016/j.jddst.2017.05.023.

Article  CAS  Google Scholar 

Pawar JN, Shete RT, Gangurde AB, Moravkar KK, Javeer SD, Jaiswar DR, Amin PD. Development of amorphous dispersions of artemether with hydrophilic polymers via spray drying: Physicochemical and in Silico Studies. Asian J Pharm Sci. 2016;11(3):385–95. https://doi.org/10.1016/j.ajps.2015.08.012.

Article  Google Scholar 

Pradhan R, Kim SY, Yong CS, Kim JO. Preparation and characterization of spray-dried valsartan-loaded Eudragit® e Po solid dispersion microparticles. Asian J Pharm Sci. 2016;11(6):744–50. https://doi.org/10.1016/j.ajps.2016.05.002.

Article  Google Scholar 

Frijlink HW, Eissens AC, Hefting NR, Poelstra K, Lerk CF, Meijer DK. The effect of parenterally administered cyclodextrins on cholesterol levels in the rat. Pharm Res. 1991;08:9–16. https://doi.org/10.1023/A:1015861719134.

Article  CAS  Google Scholar 

Palem CR, Patel S, Pokharkar VB. Solubility and stability enhancement of atorvastatin by cyclodextrin complexation. PDA J Pharm Sci Technol. 2009;63:217–25 (PMID: 20069794).

CAS  PubMed  Google Scholar 

Serajuddin ATM. Salt formation to improve drug solubility. Adv Drug Deliv Rev. 2007;59(7):603–16. https://doi.org/10.1016/j.addr.2007.05.010.

Article  CAS  PubMed  Google Scholar 

Engel GL, Farid NA, Faul MM, Richardson LA, Winneroski LL. Salt form selection and characterization of ly333531 mesylate monohydrate. Int J Pharm. 2000;198(2):239–47. https://doi.org/10.1016/S0378-5173(00)00350-1.

Article  CAS  PubMed  Google Scholar 

Ahjel SW, Lupuleasa D. Enhancement of solubility and dissolution rate of different forms of atorvastatin calcium in direct compression tablet formulas. Farmacia. 2009;57:290–300.

CAS  Google Scholar 

Devarajan PV, Sonavane GS. Preparation and in vitro/in vivo evaluation of gliclazide loaded Eudragit nanoparticles as a sustained release carriers. Drug Dev Ind Pharm. 2007;33(2):101–11. https://doi.org/10.1080/03639040601096695.

Article  CAS  PubMed  Google Scholar 

Patel H, Pandey N, Patel B, Ranch K, Bodiwala K, Vyas B. Enhancement of in vivo hypoglycemic effect of gliclazide by developing self-microemulsifying pellet dosage form. Future J Pharm Sci. 2020;6(1). https://doi.org/10.1186/s43094-020-00034-0.

Agrawal A, Kumar A, Gide P. Toxicity study of a self-nanoemulsifying drug delivery system containing N-methyl pyrrolidone. Drug Res. 2015;65(08):446–48. https://doi.org/10.1055/s-0034-1389985.

Kumar N, Chaurasia S, Patel RR, Khan G, Kumar V, Mishra B. Atorvastatin calcium encapsulated eudragit nanoparticles with enhanced oral bioavailability, safety and efficacy profile. Pharm Dev Technol. 2015;22(2):156–67. https://doi.org/10.3109/10837450.2015.1108983.

Article  CAS  PubMed  Google Scholar 

Batisai E. Solubility enhancement of antidiabetic drugs using a co-crystallization approach. Chemistry Open. 2021;10(12):1260–8. https://doi.org/10.1002/open.202100246.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arafa MF, El-Gizawy SA, Osman MA, El Maghraby GM. Co-crystallization for enhanced dissolution rate of nateglinide: In vitro and in vivo evaluation. J Drug Deliv Sci Technol. 2017;38:9–17. https://doi.org/10.1016/j.jddst.2017.01.005.

Article  CAS  Google Scholar 

Wicaksono Y, Wisudyaningsih B, Siswoyo TA. Enhancement of solubility and dissolution rate of atorvastatin calcium by co-crystallization. Trop J Pharm Res. 2017;16(7):1497. https://doi.org/10.4314/tjpr.v16i7.6.

Savjani KT, Gajjar AK, Savjani JK. Drug solubility: Importance and enhancement techniques. ISRN Pharmaceutics. 2012;1–10. https://doi.org/10.5402/2012/195727.

Patel M, Tekade A, Gattani S, Surana S. Solubility enhancement of lovastatin by modified locust bean gum using solid dispersion techniques. AAPS PharmSciTech. 2008;9(4):1262–69. https://doi.org/10.1208/s12249-008-9171-4.

Sekiguchi K, Obi N, Ueda Y. Studies on absorption of eutectic mixture. II. Absorption of fused conglomerates of chloramphenicol and urea in rabbits. Chem Pharm Bull. 1964;12(2):134–44. https://doi.org/10.1248/cpb.12.134.

Sekiguchi K, Obi N. Studies on absorption of eutectic mixture. i. A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man. Chem Pharm Bull. 1961;9(11):866–72. https://doi.org/10.1248/cpb.9.866.

Craig DQM. The mechanisms of drug release from solid dispersions in water-soluble polymers. Int J Pharm. 2002;231(2):131–44. https://doi.org/10.1016/S0378-5173(01)00891-2.

Article  CAS  PubMed  Google Scholar 

Ahmed S, Nagia El, Hanaa AF, Waleed B. Solubility enhancement of poorly water soluble drug by solid dispersion technique. Asian J Res Chem. 2012;5:483–91.

Cid AG, Simonazzi A, Palma SD, Bermudez JM. Solid dispersion technology as a strategy to improve the bioavailability of poorly soluble drugs. Ther Deliv. 2019;10(6):363–82. https://doi.org/10.4155/tde-2019-0007.

Allawadi D, Singh N, Singh S, Arora S. Cheminform abstract: Solid dispersions: A review on drug delivery system and solubility enhancement. ChemInform. 2014;45(18). https://doi.org/10.1002/chin.201418290.

Willart JF, Descamps M. Solid state amorphization of pharmaceuticals. Mol Pharm. 2008;5(6):905–20. https://doi.org/10.1021/mp800092t.

Article  CAS  PubMed  Google Scholar 

Kim JS, Kim MS, Park HJ, Jin SJ, Lee S, Hwang SJ. Physicochemical properties and oral bioavailability of amorphous atorvastatin hemi-calcium using spray-drying and SAS process. Int J Pharm. 2008;359(1–2):211–9. https://doi.org/10.1016/j.ijpharm.2008.04.006.

Article  CAS  PubMed  Google Scholar 

Desager JP, Horsmans Y. Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors. Clin Pharmacokinet. 1996;31(5):348–71. https://doi.org/10.2165/00003088-199631050-00003.

Bobe KR, Subrahmanya CR, Suresh S, Gaikwad DT, Patil MD, Khade TS, Gavitre BB, Kulkarni VS, Gaikwad UT. Formulation and evaluation of solid dispersion of atorvastatin with various carriers. Int J compr pharm. 2011;2:1–6.

Google Scholar 

Das SK. Solid dispersions : An approach to enhance the bioavailability of poorly water-soluble drugs. Int J Pharmacol Pharm Technol. 2013;37–46. https://doi.org/10.47893/ijppt.2013.1006.

Vemavarapu C, Mollan MJ, Lodaya M, Needham TE. Design and process aspects of laboratory scale SCF particle formation systems. Int J Pharm. 2005;292(1–2):1–16. https://doi.org/10.1016/j.ijpharm.2004.07.021.

Article  CAS  PubMed  Google Scholar 

York P, Kompella UB, Shekunov BY. Supercritical fluid technology for drug product development. New York: Informa Healthcare; 2008.

Google Scholar 

Rogers TL, Johnston KP, Williams RO. Solution-based particle formation of pharmaceutical powders by supercritical or compressed fluid CO2 and cryogenic spray-freezing technologies. Drug Dev Ind Pharm. 2001;27(10):1003–15. https://doi.org/10.1081/DDC-100108363.

Article  CAS  PubMed  Google Scholar 

Cilla DD, Whitfield LR, Gibson DM, Sedman AJ, Posvar EL. Multiple-dose pharmacokinetics, pharmacodynamics, and safety of Atorvastatin, an inhibitor of HMG-COA reductase, in healthy subjects. Clin Pharmacol Ther. 1996;60(6):687–95. https://doi.org/10.1016/s0009-9236(96)90218-0.

Corsini A, Bellosta S, Baetta R, Fumagalli R, Paoletti R, Bernini F. New insights into the pharmacodynamic and pharmacokinetic properties of statins. Pharmacol Ther. 1999;84(3):413–28. https://doi.org/10.1016/S0163-7258(99)00045-5.

Article  CAS  PubMed  Google Scholar 

Dixit AK, Singh RP, Singh S. Solid dispersion-a strategy for improving the solubility of poorly soluble drugs. Int J Res Pharm Biomed Sci. 2012;3:960–6.

CAS  Google Scholar 

Baste NS, Basarkar GD. Samanea saman: a novel mucoadhesive gum. Res J Pharmacogn Phytochem. 2021;57–62. https://doi.org/10.52711/0975-4385.2021.00010.

Shingne NS, Nagpure SV, Deshmane SV, Biyani KR. Modified Hupu gum: a novel application in solid dispersion containing pioglitazone HCl. Am J PharmTech Res. 2013;3:463–72.

Google Scholar 

Jangra S, Ahuja M, Kumar A. Evaluation of mucoadhesive property of Gum Ghatti. J Pharm Investig. 2013;43(6):481–7. https://doi.org/10.1007/s40005-013-0093-0.

Article  CAS  Google Scholar 

Nafee NA, Ismail FA, Boraie NA, Mortada LM. Mucoadhesive delivery systems. I. Evaluation of mucoadhesive polymers for buccal tablet formulation. Drug Dev Ind Pharm. 2004;30(9):985–93. https://doi.org/10.1081/DDC-200037245.

Murali Mohan Babu GV, Prasad ChDS, Ramana Murthy KV. Evaluation of modified Gum Karaya as carrier for the dissolution enhancement of poorly water-soluble drug nimodipine. Int J Pharm. 2002;234(1–2):1–17. https://doi.org/10.1016/S0378-5173(01)00925-5.

Padalkar AN, Shahi SR, Kale AG, Thube M, Padalkar VA. Formulation and characterization of novel solid dispersions of hydrochlorothiazide by solvent evaporation technique. Asian J Biomed Pharm Sci. 2012;2:49–56.

Google Scholar 

Rodde MS, Divase GT, Devkar TB, Tekade AR. Solubility and bioavailability enhancement of poorly aqueous soluble atorvastatin:in vitro, ex vivo, and in vivo studies. BioMed Research International. 2014:1–10. https://doi.org/10.1155/2014/463895.

Hasnain MS, Nayak AK. Solubility and dissolution enhancement of ibuprofen by solid dispersion technique using PEG 6000-PVP K 30 combination carrier. Chemistry. 2012;21:118–32.

CAS  Google Scholar 

Ratnaparkhi MP, Chaudhari PD. Solubility enhancement of poorly water soluble drug using natural carrier. International Journal of Life Science and Pharma Research. 2017;7:9–18.

Google Scholar 

Aggarwal S, Gupta GD, Chaudhary S. Solubility and dissolution enhancement of poorly aqueous soluble drug atorvastatin calcium using modified gum karaya as carrier: In vitro-In vivo evaluation. Int J Drug Deliv. 2012;4:341. https://doi.org/10.5138/ijdd.v4i3.751.

Jahangiri A, Barzegar-Jalali M, Garjani A, Javadzadeh Y, Hamishehkar H, Afroozian A, Adibkia K. Pharmacological and histological examination of atorvastatin-PVP K30 solid dispersions. Powder Technol. 2015;286:538–45. https://doi.org/10.1016/j.powtec.2015.08.047.

Article  CAS  Google Scholar 

Maurya D, Belgamwar V, Tekade A. Microwave induced solubility enhancement of poorly water soluble atorvastatin calcium. J. Pharm Pharmacol. 2010;62(11):1599–1606. https://doi.org/10.1111/j.2042-7158.2010.01187.x.

Balasubramaniam J, Bindu K, Rao VU, Ray D, Haldar R, Brzeczko AW. Effect of superdisintegrants on dissolution of Cationic Drugs. Dissolution Technol. 2008;15(2):18–25. https://doi.org/10.14227/dt150208p18.

Charumanee S, Okonoki S, Sirithunyalug J. Improvement of the dissolution rate of piroxicam by surface solid dispersion. CMU J. 2004;3:77–84.

Google Scholar