Cone-Beam computed tomography (CBCT) has revolutionized the field of interventional radiology (IR) by providing high-resolution three-dimensional imaging in real time, and enabling both comprehensive evaluation of anatomical structures and better understanding of complex anatomy [1,2]. In addition, CBCT has paved the way for the development of imaging guidance solutions, which extend the boundaries of IR treatment options to more complex procedures and anatomies [2,3]. The ability to acquire images at the point of care contributes to faster decision-making and improved workflow efficiency. These advantages contribute to increasing CBCT utilization in IR procedures, which thereby enhances procedural accuracy and improves patient outcomes. Despite these benefits, CBCT remains technically challenging and workflow optimization is needed to establish routine CBCT implementation [1]. This article aims to provide an overview of the techniques used to guide and monitor interventions that use CBCT. It discusses the advantages of CBCT and its current applications, as well as potential future developments of CBCT use in the field of interventional radiology.