The effect of methylphenidate on pain perception thresholds in children with attention deficit hyperactivity disorder

Wolraich ML, Hagan JF, Allan C, Chan E, Davison D, Earls M, Evans SW, Flinn SK, Froehlich T, Frost J, Holbrook JR, Lehmann CU, Lessin HR, Okechukwu K, Pierce KL, Winner JD, Zurhellen W. Clinical practice Guideline for the diagnosis, evaluation, and treatment of Attention-Deficit/Hyperactivity disorder in children and adolescents. Pediatrics. 2019;144. https://doi.org/10.1542/PEDS.2019-2528.

Pitcher TM, Piek JP, Hay DA. Fine and gross motor ability in males with ADHD. Dev Med Child Neurol. 2003;45:525–35. https://doi.org/10.1017/S0012162203000975.

Article  PubMed  Google Scholar 

Sergeant JA, Piek JP, Oosterlaan J. ADHD and DCD: a relationship in need of research. Hum Mov Sci. 2006;25:76–89. https://doi.org/10.1016/J.HUMOV.2005.10.007.

Article  PubMed  Google Scholar 

Piek JP, Dyck MJ. Sensory-motor deficits in children with developmental coordination disorder, attention deficit hyperactivity disorder and autistic disorder. Hum Mov Sci. 2004;23:475–88. https://doi.org/10.1016/J.HUMOV.2004.08.019.

Article  PubMed  Google Scholar 

Sharma A, Couture J. A review of the pathophysiology, etiology, and treatment of attention-deficit hyperactivity disorder (ADHD). Ann Pharmacother. 2014;48:209–25. https://doi.org/10.1177/1060028013510699.

Article  PubMed  Google Scholar 

Oades RD, Sadile AG, Sagvolden T, Viggiano D, Zuddas A, Devoto P, Aase H, Johansen EB, Ruocco LA, Russell VA. The control of responsiveness in ADHD by catecholamines: evidence for dopaminergic, noradrenergic and interactive roles. Dev Sci. 2005;8:122–31. https://doi.org/10.1111/J.1467-7687.2005.00399.X.

Article  PubMed  Google Scholar 

Chen C, Xiu D, Chen C, Moyzis R, Xia M, He Y, Xue G, Li J, He Q, Lei X, Wang Y, Liu B, Chen W, Zhu B, Dong Q. Regional homogeneity of resting-state brain activity suppresses the effect of dopamine-related genes on sensory processing sensitivity. PLoS ONE. 2015;10. https://doi.org/10.1371/JOURNAL.PONE.0133143.

Müller CP, Huston JP. Dopamine activity in the occipital and temporal cortices of rats: dissociating effects of sensory but not pharmacological stimulation. Synapse. 2007;61:254–8. https://doi.org/10.1002/SYN.20366.

Article  PubMed  Google Scholar 

Li SC, Passow S, Nietfeld W, Schröder J, Bertram L, Heekeren HR, Lindenberger U. Dopamine modulates attentional control of auditory perception: DARPP-32 (PPP1R1B) genotype effects on behavior and cortical evoked potentials. Neuropsychologia. 2013;51:1649–61. https://doi.org/10.1016/J.NEUROPSYCHOLOGIA.2013.04.005.

Article  PubMed  Google Scholar 

Cave JW, Baker H. Dopamine systems in the forebrain. Adv Exp Med Biol. 2009;651:15–35. https://doi.org/10.1007/978-1-4419-0322-8_2/COVER/.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yochman A, Parush S, of, Graduate Studies D. (2006) Co-occurrence of developmental delays among preschool children with attention-deficit-hyperactivity disorder. Dev Med Child Neurol 48:483–488. https://doi.org/10.1111/J.1469-8749.2006.TB01300.X.

Treister R, Eisenberg E, Demeter N, Pud D. Alterations in pain response are partially reversed by methylphenidate (ritalin) in adults with attention deficit hyperactivity disorder (ADHD). Pain Pract. 2015;15:4–11. https://doi.org/10.1111/PAPR.12129.

Article  PubMed  Google Scholar 

Roessner V, Banaschewski T, Fillmer-Otte A, Becker A, Albrecht B, Uebel H, Sergeant J, Tannock R, Rothenberger A. Color perception deficits in co-existing attention-deficit/hyperactivity disorder and chronic tic disorders. J Neural Transm (Vienna). 2008;115:235–9. https://doi.org/10.1007/S00702-007-0817-2.

Article  CAS  PubMed  Google Scholar 

Biederman J, Spencer TJ, Wilens TE, Weisler RH, Read SC, Tulloch SJ. Long-term safety and effectiveness of mixed amphetamine salts extended release in adults with ADHD. CNS Spectr. 2005;10:16–25. https://doi.org/10.1017/S1092852900002406.

Article  PubMed  Google Scholar 

Hysek CM, Simmler LD, Schillinger N, Meyer N, Schmid Y, Donzelli M, Grouzmann E, Liechti ME. Pharmacokinetic and pharmacodynamic effects of methylphenidate and MDMA administered alone or in combination. Int J Neuropsychopharmacol. 2014;17:371–81. https://doi.org/10.1017/S1461145713001132.

Article  CAS  PubMed  Google Scholar 

Westbrook A, van den Bosch R, Määttä JI, Hofmans L, Papadopetraki D, Cools R, Frank MJ. Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work. Sci (1979). 2020;367:1362–6. https://doi.org/10.1126/SCIENCE.AAZ5891/SUPPL_FILE/AAZ5891-WESTBROOK-SM.PDF.

Article  CAS  Google Scholar 

Mehta MA, Owen AM, Sahakian BJ, Mavaddat N, Pickard JD, Robbins TW. Methylphenidate enhances Working Memory by modulating Discrete Frontal and Parietal Lobe Regions in the human brain. J Neurosci. 2000;20:RC65–5. https://doi.org/10.1523/JNEUROSCI.20-06-J0004.2000.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jahromi LB, Kasari CL, McCracken JT, Lee LSY, Aman MG, McDougle CJ, Scahill L, Tierney E, Eugene Arnold L, Vitiello B, Ritz L, Witwer A, Kustan E, Ghuman J, Posey DJ. Positive effects of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity. J Autism Dev Disord. 2009;39:395–404. https://doi.org/10.1007/S10803-008-0636-9/FIGURES/4.

Article  PubMed  Google Scholar 

Volkow ND, Swanson JM. Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD. Am J Psychiatry. 2003;160:1909–18. https://doi.org/10.1176/APPI.AJP.160.11.1909/ASSET/IMAGES/LARGE/M22F4.JPEG.

Article  PubMed  Google Scholar 

Nevels RM, Dehon EE, Alexander K, Gontkovsky ST. Psychopharmacology of aggression in children and adolescents with primary neuropsychiatric disorders: a review of current and potentially promising treatment options. Exp Clin Psychopharmacol. 2010;18:184–201. https://doi.org/10.1037/A0018059.

Article  PubMed  Google Scholar 

Wood PB. Role of central dopamine in pain and analgesia. Expert Rev Neurother. 2008;8:781–97. https://doi.org/10.1586/14737175.8.5.781.

Article  CAS  PubMed  Google Scholar 

Potvin S, Grignon S, Synapse SM-. 2009 undefined (2009) Human evidence of a supra-spinal modulating role of dopamine on pain perception. Wiley Online Library 63:390–402. https://doi.org/10.1002/syn.20616.

Millan MJ. Descending control of pain. Prog Neurobiol. 2002;66:355–474. https://doi.org/10.1016/S0301-0082(02)00009-6.

Article  CAS  PubMed  Google Scholar 

Altier N, Stewart J. The role of dopamine in the nucleus accumbens in analgesia. Life Sci. 1999;65:2269–87. https://doi.org/10.1016/S0024-3205(99)00298-2.

Article  CAS  PubMed  Google Scholar 

Holman A, … RM-& ROJ of the, 2005 undefined (2005) A randomized, double-blind, placebo‐controlled trial of pramipexole, a dopamine agonist, in patients with fibromyalgia receiving concomitant medications. Wiley Online Library 52:2495–2505. https://doi.org/10.1002/art.21191.

Ertas M, Sagduyu A, Arac N, Uludag B, Ertekin C. Use of levodopa to relieve pain from painful symmetrical diabetic polyneuropathy. Pain. 1998;75:257–9. https://doi.org/10.1016/S0304-3959(98)00003-7.

Article  CAS  PubMed  Google Scholar 

Swensen A, Birnbaum HG, Ben Hamadi R, Greenberg P, Cremieux PY, Secnik K. Incidence and costs of accidents among attention-deficit/hyperactivity disorder patients. J Adolesc Health. 2004;35. https://doi.org/10.1016/J.JADOHEALTH.2003.12.003. :346.e1-346.e9.

Scherder EJA, Rommelse NNJ, Bröring T, Faraone SV, Sergeant JA. Somatosensory functioning and experienced pain in ADHD-families: a pilot study. Eur J Pediatr Neurol. 2008;12:461–9. https://doi.org/10.1016/J.EJPN.2007.11.004.

Article  Google Scholar 

Northover C, Thapar A, Langley K, Van Goozen SHM. Pain Sensitivity in adolescent males with Attention-Deficit/Hyperactivity disorder: Testing for Associations with Conduct Disorder and callous and unemotional traits. PLoS ONE. 2015;10. https://doi.org/10.1371/JOURNAL.PONE.0134417.

Stray LL, Kristensen Ø, Lomeland M, Skorstad M, Stray T, Tønnessen FE. Motor regulation problems and pain in adults diagnosed with ADHD. Behav Brain Funct. 2013;9. https://doi.org/10.1186/1744-9081-9-18.

Asztély K, Kopp S, Gillberg C, Waern M, Bergman S. Chronic Pain and Health-Related Quality of Life in Women with Autism And/Or ADHD: a prospective longitudinal study. J Pain Res. 2019;12:2925. https://doi.org/10.2147/JPR.S212422.

Article  PubMed  PubMed Central  Google Scholar 

American Psychiatric Association, Association D AP. Diagnostic and statistical manual of mental disorders: DSM-5. American psychiatric association Washington, DC; 2013.

Ünal F, Öktem F, Çetin Çuhadaroğlu F, Çengel Kültür SE, Akdemir D, Foto Özdemir D, Çak HT, Ünal D, Tiraş K, Aslan C, Kalayci BM, Aydos BS, Kütük F, Taşyürek E, Karaokur R, Karabucak B, Karakök B, Karaer Y, Artik A. Reliability and validity of the schedule for affective disorders and schizophrenia for school-age children-present and lifetime version, DSM-5 November 2016-Turkish adaptation (K-SADS-PL-DSM-5-T). Turk Psikiyatri Dergisi. 2019;30. https://doi.org/10.5080/U23408.

Payne LA, Seidman LC, Lung KC, Zeltzer LK, Tsao JCI. Relationship of neuroticism and laboratory pain in healthy children: does anxiety sensitivity play a role? Pain. 2013;154:103–9. https://doi.org/10.1016/J.PAIN.2012.09.013.

Article  PubMed  Google Scholar 

Kumar G, Steer RA. Factorial validity of the Conners’ parent rating Scale-revised: short form with psychiatric outpatients. J Pers Assess. 2003;80:252–9. https://doi.org/10.1207/S15327752JPA8003_04.

Article  PubMed  Google Scholar 

Kaner S, Buyukozturk S, Iseri E. Conners parent rating scale-revised short: turkish standardization study/Conners anababa dereceleme olcegi-yenilenmis kisa: Turkiye stardardizasyon calismasi. Archives of Neuropsychiatry. 2013;50:100–10.

Article  Google Scholar 

Stinson JN, Kavanagh T, Yamada J, Gill N, Stevens B. Systematic review of the psychometric properties, interpretability and feasibility of self-report pain intensity measures for use in clinical trials in children and adolescents. Pain. 2006;125:143–57. https://doi.org/10.1016/J.PAIN.2006.05.006.

Article  PubMed  Google Scholar 

Chaves TC, Nagamine HM, de Sousa LM, de Oliveira AS, Grossi DB. (2007) Intra-and interrater agreement of pressure pain threshold for masticatory structures in children reporting orofacial pain related to temporomandibular disorders and symptom-free children. J Orofac Pain 21.

Wolff N, Rubia K, Knopf H, Hölling H, Martini J, Ehrlich S, Roessner V. Reduced pain perception in children and adolescents with ADHD is normalized by methylphenidate. Child Adolesc Psychiatry Ment Health. 2016;10:24. https://doi.org/10.1186/S13034-016-0112-9.

Article  PubMed  PubMed Central  Google Scholar 

Smith A, Taylor E, Rogers JW, Newman S, Rubia K. Evidence for a pure time perception deficit in children with ADHD. J Child Psychol Psychiatry. 2002;43:529–42. https://doi.org/10.1111/1469-7610.00043.

Article  PubMed  Google Scholar 

Da Fonseca D, Seguier V, Santos A, Poinso F, Deruelle C. Emotion understanding in children with ADHD. Child Psychiatry Hum Dev. 2009;40:111–21. https://doi.org/10.1007/S10578-008-0114-9/METRICS.

Article  PubMed  Google Scholar 

Fisher O, Berger I, Grossman ES, Maeir A. Online and intellectual awareness of executive functioning in Daily Life among adolescents with and without ADHD. J Atten Disord. 2022;26:870–80. https://doi.org/10.1177/10870547211031982.

Article  PubMed  Google Scho

Comments (0)

No login
gif