ATM-AMPKα mediated LAG-3 expression suppresses T cell function in prostate cancer

LAG3

Lymphocyte-activation gene 3

CTLA4

Cytotoxic T-lymphocyte-associated protein 4

TIGIT

T cell Ig and ITIM domain

TIM-3

T cell immunoglobulin and mucin domain-3

ICOS

inducible T-cell costimulator

FGL1

Fibrinogen-like protein 1

ATM

Ataxia telangiectasia mutated

AMPKα

AMP activated protein kinase α

XBP1

X-box binding protein 1

EGR2

Early growth response protein 2

FACS

Fluorescent-activated cell sorting

MFI

Mean fluorescence intensity

PBMCs

Peripheral Blood Mononuclear Cells

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