BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps

Edlich F, Banerjee S, Suzuki M, Cleland MM, Amoult D, Wang C, Neutzner A, Tjandra N, Youle RJ. Bcl-XL retrotranslocates Bax from the mitochondria into the cytosol. Cell. 2011;145:104–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Todt F, Reichenbach F, Youle RJ, Edlich F. The C-terminal helix of Bcl-X mediates Bax retrotranslocation from the mitochondria. Cell Death Differ. 2013;20:333–42.

Article  CAS  PubMed  Google Scholar 

Todt F, Cakir Z, Reichenbach F, Emschermann F, Lauterwasser J, Kaiser A, Ichim G, Tait SWG, Frank S, Langer HF, Edlich F. Differential retrotranslocation of mitochondrial Bax and Bak. EMBO J. 2014;34:67–80.

Article  PubMed  PubMed Central  Google Scholar 

Gavathiotis E, Reyna DE, Davis ML, Bird GH, Walensky LD. BH3-triggered structural reorganization drives the activation of proapoptotic BAX. Mol Cell. 2010;40:481–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Happo L, Strasser A, Cory S. BH3-only proteins in apoptosis at a glance. J Cell Sci. 2012;125:1081–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hsu Y-T, Wolter KG, Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-XL during apoptosis. Proc Natl Acad Sci USA. 1997;94:3668–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ. Movement of bax from the cytosol to mitochondria during apoptosis. J Cell Biol. 1997;139:1281–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nechushtan A, Smith CL, Lamensdorf I, Yoon SH, Youle RJ. Bax and Bak coalesce into novel mitochondrial-associated clusters during apoptosis. J Cell Biol. 2001;153:1265–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karbowski M, Lee YJ, Gaume B, Jeong SY, Frank S, Nechushtan A, Santel A, Fuller M, Smith CL, Youle RJ. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J Cell Biol. 2002;159:931–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldstein JC, Waterhouse NJ, Juin P, Evan GI, Green DR. The coordinate release of cytochrome c during apoptosis is rapid, complete, and kinetically invariant. Nat Cell Biol. 2000;2:156–62.

Article  CAS  PubMed  Google Scholar 

Maes ME, Schlamp CL, Nickells RW. Live-cell imaging to measure BAX recruitment kinetics to mitochondria during apoptosis. PLoS ONE. 2017;12: e0184434.

Article  PubMed  PubMed Central  Google Scholar 

Xu XP, Zhai D, Kim E, Swift M, Reed JC, Volkmann N, Hanein D. Three dimensional structure of Bax-mediated pores in membrane bilayers. Cell Death Disease. 2013;4:e683.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gilmore AP. Anoikis. Cell Death Differ. 2005;12:1473–7.

Article  CAS  PubMed  Google Scholar 

Valentijn AJ, Metcalfe AD, Kott J, Streuli CH, Gilmore AP. Spatial and temporal changes in Bax subcellular localization during anoikis. J Cell Biol. 2003;162:599–612.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040. Ophthalmology. 2014;121:2081–90.

Article  PubMed  Google Scholar 

Bonfanti L, Strettoi E, Chierzi S, Cenni MC, Liu X-H, Martinou JC, Maffei L, Rabacchi SA. Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2. J Neurosci. 1996;16:4186–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cenni MC, Bonfanti L, Martinou J-C, Ratto GM, Strettoi E, Maffei L. Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice. Eur J Neurosci. 1996;8:1735–45.

Article  CAS  PubMed  Google Scholar 

Harder JM, Ding Q, Fernandes KA, Cherry JD, Gan L, Libby RT. BCL2L1 (BCL-X) promotes survivial of adult and developing retinal ganglion cells. Mol Cell Neurosci. 2012;51:53–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malik JMI, Shevtsova Z, Bahr M, Kugler S. Long-term in vivo inhibition of CNS neurodegeneration by BclXL gene transfer. Mol Ther. 2005;11:373–81.

Article  CAS  PubMed  Google Scholar 

Liu XH, Collier RJ, Youle RJ. Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein. J Biol Chem. 2001;276:46326–32.

Article  CAS  PubMed  Google Scholar 

Donahue RJ, Fehrman RL, Gustafson JR, Nickells RW. BCLX(L) gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma. Cell Death Disease. 2021;12:781.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mosinger Ogilvie J, Deckwerth TL, Knudson CM, Korsmeyer SJ. Suppression of developmental retinal cell death but not photoreceptor degeneration in Bax-deficient mice. Invest Ophthalmol Vis Sci. 1998;39:1713–20.

CAS  Google Scholar 

Li Y, Schlamp CL, Poulsen KP, Nickells RW. Bax-dependent and independent pathways of retinal ganglion cell death induced by different damaging stimuli. Exp Eye Res. 2000;71:209–13.

Article  CAS  Google Scholar 

Semaan SJ, Li Y, Nickells RW. A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death. ASN Neuro. 2010;2:e00032.

Article  PubMed  PubMed Central  Google Scholar 

Donahue RJ, Maes ME, Grosser JA, Nickells RW. BAX depleted retinal ganglion cells survive and become quiescent following optic nerve damage. Mol Neurobiol. 2020;57:1070–84.

Article  CAS  PubMed  Google Scholar 

Libby RT, Li Y, Savinova OV, Barter J, Smith RS, Nickells RW, John SWM. Susceptibility to neurodegeneration in glaucoma is modified by Bax gene dosage. PLoS Genet. 2005;1:17–26.

Article  CAS  PubMed  Google Scholar 

Howell GR, Libby RT, Jakobs TC, Smith RS, Phalan FC, Barter JW, Barbay JM, Marchant JK, Mahesh N, Porciatti V, Whitmore AV, Masland RH, John SWM. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol. 2007;179:1523–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jakobson M, Lintulahti A, Arumae U. mRNA for N-Bak, a neuron-specific BH3-only splice isoform of Bak, escapes nonsense-mediated decay and is translationally repressed in neurons. Cell Death Dis. 2012;3:e269.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun YF, Yu LY, Saarma M, Arumae U. Mutational analysis of N-Bak reveals different structural requirements for antiapoptotic activity in neurons and proapoptotic activity in nonneuronal cells. Mol Cell Neurosci. 2003;23:134–43.

Article  PubMed  Google Scholar 

Uo T, Kinoshita Y, Morrison RS. Neurons exclusively express N-Bak, a BH3 domain-only Bak isoform that promotes neuronal apoptosis. J Biol Chem. 2005;280:9065–73.

Article  CAS  PubMed  Google Scholar 

Schmitt HM, Fehrman RL, Maes ME, Yang H, Guo LW, Schlamp CL, Pelzel HR, Nickells RW. Increased susceptibility and intrinsic apoptotic signaling in neurons by induced HDAC3 expression. Invest Ophthalmol Vis Sci. 2021;62:14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maes ME, Schlamp CL, Nickells RW. BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells. Prog Retin Eye Res. 2017;57:1–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen ST, Garey LJ, Jen LS. Bcl2 proto-oncogene protein immunoreactivity in normally developing and axotomised rat retinas. Neurosci Lett. 1994;172:11–4.

Article  CAS  PubMed  Google Scholar 

Levin LA, Schlamp CL, Spieldoch RL, Geszvain KM, Nickells RW. Identification of bcl-2 family genes in the rat retina. Invest Ophthalmol Vis Sci. 1997;38:2545–53.

CAS  PubMed  Google Scholar 

Watkins TA, Wang B, Huntwork-Rodriguez S, Yang J, Jiang Z, Eastham-Anderson J, Modrusan Z, Kaminker JS, Tessier-Lavigne M, Lewcock JW. DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proc Natl Acad Sci USA. 2013;110:4039–44.

留言 (0)

沒有登入
gif