These authors contributed equally: Donge Tang, Jiaxi He, Yong Dai

Research Center of Medical Sciences, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China

Donge Tang & Songhui Xu

Department of Clinical Medical Research Center, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital Southern University of Science and Technology, Shenzhen People’s Hospital, Shenzhen, Guangdong, China

Donge Tang & Yong Dai

Department of Pathology, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA

Jiaxi He, Qixin Leng & Songhui Xu

Department of Biochemistry, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA

Xinyan Geng

Department of Anesthesiology and Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, USA

Haowu Jiang

Department of Internal Medicine, Yale University, New Haven, CT, USA

Rui Sun