Association of metabolically unhealthy non-obese and metabolically healthy obese individuals with arterial stiffness and 10-year cardiovascular disease risk: a cross-sectional study in Chinese adults

Koliaki C, Liatis S, Kokkinos A. Obesity and cardiovascular disease: revisiting an old relationship. Metabolism. 2019;92:98–107.

Article  CAS  PubMed  Google Scholar 

Laakso M, Kuusisto J. Insulin resistance and hyperglycaemia in cardiovascular disease development. Nat Rev Endocrinol. 2014;10:293–302.

Article  CAS  PubMed  Google Scholar 

Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444:881–7.

Article  CAS  PubMed  Google Scholar 

Aung K, Lorenzo C, Hinojosa MA, Haffner SM. Risk of developing diabetes and cardiovascular disease in metabolically unhealthy normal-weight and metabolically healthy obese individuals. J Clin Endocrinol Metab. 2014;99:462–8.

Article  CAS  PubMed  Google Scholar 

Eckel N, Li Y, Kuxhaus O, Stefan N, Hu FB, Schulze MB. Transition from metabolic healthy to unhealthy phenotypes and association with cardiovascular disease risk across BMI categories in 90 257 women (the Nurses’ Health Study): 30 year follow-up from a prospective cohort study. Lancet Diabetes Endocrinol. 2018;6:714–24.

Article  PubMed  Google Scholar 

Yoo HJ, Hwang SY, Hong HC, Choi HY, Seo JA, Kim SG, et al. Association of metabolically abnormal but normal weight (MANW) and metabolically healthy but obese (MHO) individuals with arterial stiffness and carotid atherosclerosis. Atherosclerosis. 2014;234:218–23.

Article  CAS  PubMed  Google Scholar 

Choi KM, Cho HJ, Choi HY, Yang SJ, Yoo HJ, Seo JA, et al. Higher mortality in metabolically obese normal-weight people than in metabolically healthy obese subjects in elderly Koreans. Clin Endocrinol (Oxf). 2013;79:364–70.

Article  PubMed  Google Scholar 

Mongraw-Chaffin M, Foster MC, Anderson CAM, Burke GL, Haq N, Kalyani RR, et al. Metabolically healthy obesity, transition to metabolic syndrome, and Cardiovascular Risk. J Am Coll Cardiol. 2018;71:1857–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calori G, Lattuada G, Piemonti L, Garancini MP, Ragogna F, Villa M, et al. Prevalence, metabolic features, and prognosis of metabolically healthy obese italian individuals: the Cremona Study. Diabetes Care. 2011;34:210–5.

Article  PubMed  Google Scholar 

Kouvari M, Panagiotakos DB, Yannakoulia M, Georgousopoulou E, Critselis E, Chrysohoou C, et al. Transition from metabolically benign to metabolically unhealthy obesity and 10-year cardiovascular disease incidence: the ATTICA cohort study. Metabolism. 2019;93:18–24.

Article  CAS  PubMed  Google Scholar 

Opio J, Croker E, Odongo GS, Attia J, Wynne K, McEvoy M. Metabolically healthy overweight/obesity are associated with increased risk of cardiovascular disease in adults, even in the absence of metabolic risk factors: a systematic review and meta-analysis of prospective cohort studies. Obes Rev. 2020;21:e13127.

Article  PubMed  Google Scholar 

Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010;55:1318–27.

Article  PubMed  Google Scholar 

Lee SB, Ahn CW, Lee BK, Kang S, Nam JS, You JH, et al. Association between triglyceride glucose index and arterial stiffness in korean adults. Cardiovasc Diabetol. 2018;17:41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park B, Lee YJ. Borderline high serum calcium levels are associated with arterial stiffness and 10-year cardiovascular disease risk determined by Framingham risk score. J Clin Hypertens (Greenwich). 2019;21:668–73.

Article  CAS  PubMed  Google Scholar 

Lin L, Zhang J, Jiang L, Du R, Hu C, Lu J, et al. Transition of metabolic phenotypes and risk of subclinical atherosclerosis according to BMI: a prospective study. Diabetologia. 2020;63:1312–23.

Article  PubMed  Google Scholar 

Echouffo-Tcheugui JB, Short MI, Xanthakis V, Field P, Sponholtz TR, Larson MG, et al. Natural history of obesity subphenotypes: dynamic changes over two decades and prognosis in the Framingham Heart Study. J Clin Endocrinol Metab. 2019;104:738–52.

Article  PubMed  Google Scholar 

Stefan N, Schick F, Haring HU. Causes, characteristics, and Consequences of metabolically unhealthy normal weight in humans. Cell Metab. 2017;26:292–300.

Article  CAS  PubMed  Google Scholar 

Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, et al. Brachial-ankle pulse Wave Velocity and the risk prediction of Cardiovascular Disease: an individual Participant Data Meta-Analysis. Hypertension. 2017;69:1045–52.

Article  CAS  PubMed  Google Scholar 

Hsu PC, Lee WH, Tsai WC, Chen YC, Chu CY, Yen HW, et al. Comparison between estimated and brachial-ankle pulse wave velocity for cardiovascular and overall mortality prediction. J Clin Hypertens (Greenwich). 2021;23:106–13.

Article  PubMed  Google Scholar 

Wang A, Su Z, Liu X, Yang Y, Chen S, Wang S, et al. Brachial-ankle pulse wave velocity and metabolic syndrome in general population: the APAC study. BMC Cardiovasc Disord. 2016;16:228.

Article  PubMed  PubMed Central  Google Scholar 

Gomez-Sanchez L, Garcia-Ortiz L, Patino-Alonso MC, Recio-Rodriguez JI, Fernando R, Marti R, et al. Association of metabolic syndrome and its components with arterial stiffness in caucasian subjects of the MARK study: a cross-sectional trial. Cardiovasc Diabetol. 2016;15:148.

Article  PubMed  PubMed Central  Google Scholar 

Yuan Y, Mu JJ, Chu C, Zheng WL, Wang Y, Hu JW, et al. Effect of metabolically healthy obesity on the development of arterial stiffness: a prospective cohort study. Nutr Metab (Lond). 2020;17:50.

Article  CAS  PubMed  Google Scholar 

Wang A, Wang Y, Zuo Y, Tian X, Chen S, Ma Y, et al. Risk of arterial stiffness according to metabolically healthy obese phenotype: a combined cross-sectional and longitudinal study in kailuan cohort. Aging. 2021;13:15114–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adair KE, Padgett RN, von Waaden N, Wilson RL, Bowden RG. Metabolic health, obesity, and Cardiovascular Disease: 2015–2016 National Health and Nutrition Examination Survey. Am J Med Sci. 2021;361:244–52.

Article  PubMed  Google Scholar 

Karlsson T, Rask-Andersen M, Pan G, Hoglund J, Wadelius C, Ek WE, et al. Contribution of genetics to visceral adiposity and its relation to cardiovascular and metabolic disease. Nat Med. 2019;25:1390–5.

Article  CAS  PubMed  Google Scholar 

Kim M, Paik JK, Kang R, Kim SY, Lee SH, Lee JH. Increased oxidative stress in normal-weight postmenopausal women with metabolic syndrome compared with metabolically healthy overweight/obese individuals. Metabolism. 2013;62:554–60.

Article  CAS  PubMed  Google Scholar 

Kim TN, Park MS, Yang SJ, Yoo HJ, Kang HJ, Song W, et al. Body size phenotypes and low muscle mass: the korean sarcopenic obesity study (KSOS). J Clin Endocrinol Metab. 2013;98:811–7.

Article  CAS  PubMed  Google Scholar 

Schulze MB. Metabolic health in normal-weight and obese individuals. Diabetologia. 2019;62:558–66.

Article  PubMed  Google Scholar 

Guo X, Li Z, Zhou Y, Yu S, Yang H, Sun G et al. The effects of transitions in metabolic health and obesity status on incident cardiovascular disease: insights from a general chinese population. Eur J Prev Cardiol 2020:2047487320935550.

Cho YK, Kang YM, Yoo JH, Lee J, Park JY, Lee WJ, et al. Implications of the dynamic nature of metabolic health status and obesity on risk of incident cardiovascular events and mortality: a nationwide population-based cohort study. Metabolism. 2019;97:50–6.

Article  CAS  Google Scholar 

Itoh H, Kaneko H, Kiriyama H, Yoshida Y, Nakanishi K, Mizuno Y, et al. Effect of metabolically healthy obesity on the development of Carotid Plaque in the General Population: A Community-Based Cohort Study. J Atheroscler Thromb. 2020;27:155–63.

Article  PubMed  PubMed Central  Google Scholar 

Fan J, Song Y, Chen Y, Hui R, Zhang W. Combined effect of obesity and cardio-metabolic abnormality on the risk of cardiovascular disease: a meta-analysis of prospective cohort studies. Int J Cardiol. 2013;168:4761–8.

Article  PubMed  Google Scholar 

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