Available online 9 September 2023, 101869

This research received funding from the Instituto de Salud Carlos (III) Madrid, Spain [PI21/01771, CD22/00087 and INT22/00009]. This grant is partially financed by the European Regional Development Fund of the EU (FEDER).

The author declare no conflict of interest.

Colorectal cancer (CRC) is a relevant health problem with approximately 1.9 million new cases diagnosed in 2020 and the second cause of cancer related death globally.[1] CRC is associated with the Western World style of life as well as with the ageing population. Health authorities have devised two main strategies to reduce the impact of CRC: screening in average- and high-risk populations and early detection in symptomatic patients. [2, 3, 4, 5, 6]

In this Special Issue, the authors have

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