Boland B, Yu WH, Corti O, Mollereau B, Henriques A, Bezard E, Pastores GM, Rubinsztein DC, Nixon RA, Duchen MR, Mallucci GR, Kroemer G, Levine B, Eskelinen EL, Mochel F, Spedding M, Louis C, Martin OR, Millan MJ (2018) Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing. Nat Rev Drug Discov 17:660–688

Article  CAS  PubMed  PubMed Central  Google Scholar 

Busche MA, Hyman BT (2020) Synergy between amyloid-beta and tau in Alzheimer’s disease. Nat Neurosci 23:1183–1193

Article  CAS  PubMed  Google Scholar 

Caballero B et al (2021) Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nat Commun 12:2238

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai CZ, Zhuang XX, Zhu Q, Wu MY, Su H, Wang XJ, Iyaswamy A, Yue Z, Wang Q, Zhang B, Xue Y, Tan J, Li M, He H, Lu JH (2022) Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models. Theranostics 12:1738–1755

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chandra S, Jana M, Pahan K (2018) Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer’s Disease via PPARalpha. J Neurosci 38:6682–6699

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chandra S, Roy A, Jana M, Pahan K (2019) Cinnamic acid activates PPARalpha to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer’s disease mouse model. Neurobiol Dis 124:379–395

Article  CAS  PubMed  Google Scholar 

Chen F, Ghosh A, Lin J, Zhang C, Pan Y, Thakur A, Singh K, Hong H, Tang S (2020) 5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer’s disease. Brain Behav Immun 88:844–855

Article  CAS  PubMed  Google Scholar 

d’Errico P, Meyer-Luehmann M (2020) Mechanisms of Pathogenic Tau and Abeta Protein Spreading in Alzheimer’s Disease. Front Aging Neurosci 12:265

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktaschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA (2019) Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease. Nat Neurosci 22:401–412

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frisoni GB, Altomare D, Thal DR, Ribaldi F, van der Kant R, Ossenkoppele R, Blennow K, Cummings J, van Duijn C, Nilsson PM, Dietrich PY, Scheltens P, Dubois B (2022) The probabilistic model of Alzheimer disease: the amyloid hypothesis revised. Nat Rev Neurosci 23:53–66

Article  CAS  PubMed  Google Scholar 

Gaurav I, Thakur A, Iyaswamy A, Wang X, Chen X, Yang Z (2021) Factors affecting extracellular vesicles based drug delivery systems. Molecules 26

Gaurav I, Thakur A, Kumar G, Long Q, Zhang K, Sidu RK, Thakur S, Sarkar RK, Kumar A, Iyaswamy A, Yang Z (2023) Delivery of apoplastic extracellular vesicles encapsulating green-synthesized silver nanoparticles to treat citrus canker. Nanomaterials (Basel) 13

Gherardelli C, Cisternas P, Inestrosa NC (2022) Lithium enhances hippocampal glucose metabolism in an in vitro mice model of alzheimer's disease. Int J Mol Sci 23

Hampel H, Lista S, Mango D, Nistico R, Perry G, Avila J, Hernandez F, Geerts H, Vergallo A, Alzheimer Precision Medicine I (2019) Lithium as a Treatment for Alzheimer’s Disease: The Systems Pharmacology Perspective. J Alzheimers Dis 69:615–629

Article  PubMed  Google Scholar 

Hong M, Chen DC, Klein PS, Lee VM (1997) Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3. J Biol Chem 272:25326–25332

Article  CAS  PubMed  Google Scholar 

Iyaswamy A, Lu K, Guan XJ, Kan Y, Su C, Liu J, Jaganathan R, Vasudevan K, Paul J, Thakur A, Li M (2023) Impact and advances in the role of bacterial extracellular vesicles in neurodegenerative disease and its therapeutics. Biomedicines 11

Iyaswamy A, Krishnamoorthi SK, Zhang H, Sreenivasmurthy SG, Zhu Z, Liu J, Su CF, Guan XJ, Wang ZY, Cheung KH, Song JX, Durairajan SSK, Li M (2021) Qingyangshen mitigates amyloid-beta and Tau aggregate defects involving PPARalpha-TFEB activation in transgenic mice of Alzheimer’s disease. Phytomedicine 91:153648

Article  CAS  PubMed  Google Scholar 

Iyaswamy A, Krishnamoorthi SK, Song JX, Yang CB, Kaliyamoorthy V, Zhang H, Sreenivasmurthy SG, Malampati S, Wang ZY, Zhu Z, Tong BC, Cheung KH, Lu JH, Durairajan SSK, Li M (2020a) NeuroDefend, a novel Chinese medicine, attenuates amyloid-beta and tau pathology in experimental Alzheimer’s disease models. J Food Drug Anal 28:132–146

Article  CAS  PubMed  Google Scholar 

Iyaswamy A, Krishnamoorthi SK, Liu YW, Song JX, Kammala AK, Sreenivasmurthy SG, Malampati S, Tong BCK, Selvarasu K, Cheung KH, Lu JH, Tan JQ, Huang CY, Durairajan SSK, Li M (2020b) Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease. Front Pharmacol 11:584770

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iyaswamy A, Wang X, Krishnamoorthi S, Kaliamoorthy V, Sreenivasmurthy SG, Kumar Durairajan SS, Song JX, Tong BC, Zhu Z, Su CF, Liu J, Cheung KH, Lu JH, Tan JQ, Li HW, Wong MS, Li M (2022) Theranostic F-SLOH mitigates Alzheimer’s disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer’s disease models. Redox Biol 51:102280

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, Li Q, Shoemaker BA, Thiessen PA, Yu B, Zaslavsky L, Zhang J, Bolton EE (2021) PubChem in 2021: new data content and improved web interfaces. Nucleic Acids Res 49:D1388–D1395

Article  CAS  PubMed  Google Scholar 

Laskowski RA, Swindells MB (2011) LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. J Chem Inf Model 51:2778–2786

Article  CAS  PubMed  Google Scholar 

Luo R, Su LY, Li G, Yang J, Liu Q, Yang LX, Zhang DF, Zhou H, Xu M, Fan Y, Li J, Yao YG (2020) Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model. Autophagy 16:52–69

Article  CAS  PubMed  Google Scholar 

Ma XX, Wang D, Zhang YJ, Yang CR (2011) Identification of new qingyangshengenin and caudatin glycosides from the roots of Cynanchum otophyllum. Steroids 76:1003–1009

Article  CAS  PubMed  Google Scholar 

Maesako M, Houser MCQ, Turchyna Y, Wolfe MS, Berezovska O (2022) Presenilin/gamma-Secretase Activity Is Located in Acidic Compartments of Live Neurons. J Neurosci 42:145–154

Article  CAS  PubMed  PubMed Central  Google Scholar 

McDade E, Llibre-Guerra JJ, Holtzman DM, Morris JC, Bateman RJ (2021) The informed road map to prevention of Alzheimer Disease: A call to arms. Mol Neurodegener 16:49

Article  PubMed  PubMed Central  Google Scholar 

McGrowder DA, Miller F, Vaz K, Nwokocha C, Wilson-Clarke C, Anderson-Cross M, Brown J, Anderson-Jackson L, Williams L, Latore L, Thompson R, Alexander-Lindo R (2021) Cerebrospinal fluid biomarkers of alzheimer's disease: current evidence and future perspectives. Brain Sci 11

Munoz-Ruiz P, Rubio L, Garcia-Palomero E, Dorronsoro I, del Monte-Millan M, Valenzuela R, Usan P, de Austria C, Bartolini M, Andrisano V, Bidon-Chanal A, Orozco M, Luque FJ, Medina M, Martinez A (2005) Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer’s disease. J Med Chem 48:7223–7233

Article  CAS  PubMed  Google Scholar 

Nie D, Peng Y, Li M, Liu X, Zhu M, Ye L (2018) Lithium chloride (LiCl) induced autophagy and downregulated expression of transforming growth factor beta-induced protein (TGFBI) in granular corneal dystrophy. Exp Eye Res 173:44–50

Article  CAS  PubMed  Google Scholar 

Oyama T, Toyota K, Waku T, Hirakawa Y, Nagasawa N, Kasuga JI, Hashimoto Y, Miyachi H, Morikawa K (2009) Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures. Acta Crystallogr D Biol Crystallogr 65:786–795

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parums DV (2021) Editorial: Targets for Disease-Modifying Therapies in Alzheimer’s Disease, Including Amyloid beta and Tau Protein. Med Sci Monit 27:e934077

PubMed  PubMed Central  Google Scholar 

Patel D, Roy A, Pahan K (2020) PPARalpha serves as a new receptor of aspirin for neuroprotection. J Neurosci Res 98:626–631

Article  CAS  PubMed  Google Scholar 

Patel D, Roy A, Kundu M, Jana M, Luan CH, Gonzalez FJ, Pahan K (2018) Aspirin binds to PPARalpha to stimulate hippocampal plasticity and protect memory. Proc Natl Acad Sci U S A 115:E7408–E7417

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng Y, Ding Y (2015) Pharmacokinetics and tissue distribution study of caudatin in normal and diethylnitrosamine-induced hepatocellular carcinoma model rats. Molecules 20:4225–4237

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE (2004) UCSF Chimera–a visualization system for exploratory research and analysis. J Comput Chem 25:1605–1612

Article  CAS  PubMed  Google Scholar 

Qian X, Li B, Li P, Wang D, Dai W, Zhang M (2017) C21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells. Phytochemistry 140:1–15

Article  CAS  PubMed  Google Scholar 

Qu XX, He JH, Cui ZQ, Yang T, Sun XH (2022) PPAR-alpha Agonist GW7647 Protects Against Oxidative Stress and Iron Deposit via GPx4 in a Transgenic Mouse Model of Alzheimer’s Diseases. ACS Chem Neurosci 13:207–216

Article  CAS