Wang, X., Xu, J. & Kang, Q. Neuromodulation of bone: role of different peptides and their interactions (Review). Mol. Med. Rep 23, 32 (2021).

CAS  PubMed  Google Scholar 

Yao, D. et al. Bone metabolism regulation: implications for the treatment of bone diseases. Biomed. Pharmacother. 129, 110494 (2020).

Article  CAS  PubMed  Google Scholar 

Sharan, K. & Yadav, V. K. Hypothalamic control of bone metabolism. Best. Pr. Res. Clin. Endocrinol. Metab. 28, 713–723 (2014).

Article  CAS  Google Scholar 

Wee, N. K., Kulkarni, R. N., Horsnell, H. & Baldock, P. A. The brain in bone and fuel metabolism. Bone 82, 56–63 (2016).

Article  CAS  PubMed  Google Scholar 

Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S. & Schwartz, M. W. Central nervous system control of food intake and body weight. Nature 443, 289–295 (2006).

Article  CAS  PubMed  Google Scholar 

Karsenty, G. & Khosla, S. The crosstalk between bone remodeling and energy metabolism: a translational perspective. Cell Metab. 34, 805–817 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Corr, A., Smith, J. & Baldock, P. Neuronal control of bone remodeling. Toxicol. Pathol. 45, 894–903 (2017).

Article  CAS  PubMed  Google Scholar 

Driessler, F. & Baldock, P. A. Hypothalamic regulation of bone. J. Mol. Endocrinol. 45, 175–181 (2010).

Article  CAS  PubMed  Google Scholar 

Elefteriou, F. Impact of the autonomic nervous system on the skeleton. Physiol. Rev. 98, 1083–1112 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brazill, J. M., Beeve, A. T., Craft, C. S., Ivanusic, J. J. & Scheller, E. L. Nerves in bone: evolving concepts in pain and anabolism. J. Bone Min. Res. 34, 1393–1406 (2019).

Article  Google Scholar 

Wang, X. D. et al. The neural system regulates bone homeostasis via mesenchymal stem cells: a translational approach. Theranostics 10, 4839–4850 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu, J. et al. The effects of calcitonin gene-related peptide on bone homeostasis and regeneration. Curr. Osteoporos. Rep. 18, 621–632 (2020).

Article  PubMed  Google Scholar 

Li, F. X. et al. The role of substance p in the regulation of bone and cartilage metabolic activity. Front. Endocrinol. (Lausanne) 11, 77 (2020).

Article  PubMed  Google Scholar 

Kawai, M., Kinoshita, S., Shimba, S., Ozono, K. & Michigami, T. Sympathetic activation induces skeletal Fgf23 expression in a circadian rhythm-dependent manner. J. Biol. Chem. 289, 1457–1466 (2014).

Article  CAS  PubMed  Google Scholar 

Takeda, S. et al. Leptin regulates bone formation via the sympathetic nervous system. Cell 111, 305–317 (2002).

Article  CAS  PubMed  Google Scholar 

Lv, X., Gao, F. & Cao, X. Skeletal interoception in bone homeostasis and pain. Cell Metab. 34, 1914–1931 (2022).

Article  CAS  PubMed  Google Scholar 

Xia, Z. Skeletal interoception: an emerging area for musculoskeletal research. Biomater. Transl. 3, 237–239 (2022).

PubMed  PubMed Central  Google Scholar 

Zhen, G. & Cao, X. Targeting TGF beta signaling in subchondral bone and articular cartilage homeostasis. Trends Pharmacol. Sci. 35, 227–236 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bian, Q. et al. Excessive activation of TGF beta by spinal instability causes vertebral endplate sclerosis. Sci. Rep 6, 27093 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu, J. et al. Aberrant subchondral osteoblastic metabolism modifies Na-v 1.8 for osteoarthritis. Elife 9, e57656 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tozzi, A. Information processing in the CNS: a supramolecular chemistry. Cogn. Neurodyn. 9, 463–477 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Petty, S. J., Wilding, H. & Wark, J. D. Osteoporosis associated with epilepsy and the use of anti-epileptics-a review. Curr. Osteoporos. Rep. 14, 54–65 (2016).

Article  PubMed  Google Scholar 

Kishimoto, T., De Hert, M., Carlson, H. E., Manu, P. & Correll, C. U. Osteoporosis and fracture risk in people with schizophrenia. Curr. Opin. Psychiatry 25, 415–429 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Huang, W.-S. et al. Post-traumatic stress disorder and risk of osteoporosis: a nationwide longitudinal study. Stress Health 34, 440–445 (2018).

Article  PubMed  Google Scholar 

Aloumanis, K. & Mavroudis, K. The “depressive” face of osteoporosis and the “osteoporotic” face of depression. Hormones-Int. J. Endocrinol. Metab. 12, 350–362 (2013).

Google Scholar 

Carda, S., Cisari, C., Invernizzi, M. & Bevilacqua, M. Osteoporosis after stroke: a review of the causes and potential treatments. Cerebrovasc. Dis. 28, 191–200 (2009).

Article  PubMed  Google Scholar 

Chen, Y.-H. & Lo, R. Y. Alzheimer’s disease and osteoporosis. Tzu-chi Med. J. 29, 138–142 (2017).

Article  PubMed Central  Google Scholar 

Ezzatian-Ahar, S., Schwarz, P. & Pedersen, S. W. Osteoporosis often occurs in Parkinson’s disease patients. Ugeskrift for laeger 176, 36 (2014).

Google Scholar 

Takenouchi, T., Sato, W., Torii, C. & Kosaki, K. Progressive cognitive decline in an adult patient with cleidocranial dysplasia. Eur. J. Med. Genet. 57, 319–321 (2014).

Article  PubMed  Google Scholar 

Otto, E. et al. Crosstalk of brain and bone-clinical observations and their molecular bases. Int. J. Mol. Sci. 21, 4946 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang, C. et al. The effect of traumatic brain injury on bone healing from a novel exosome centered perspective in a mice model. J. Orthop. Transl. 30, 70–81 (2021).

Google Scholar 

Bajwa, N. M., Kesavan, C. & Mohan, S. Long-term consequences of traumatic brain injury in bone metabolism. Front. Neurol. 9, 115 (2018).

Article  PubMed  PubMed Central  Google Scholar 

McDonald, S. J., Sun, M., Agoston, D. V. & Shultz, S. R. The effect of concomitant peripheral injury on traumatic brain injury pathobiology and outcome. J. Neuroinflammation 13, 90 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Sullivan, M. P., Torres, S. J., Mehta, S. & Ahn, J. Heterotopic ossification after central nervous system trauma: a current review. Bone Jt. Res. 2, 51–57 (2013).

Article  CAS  Google Scholar 

Ducy, P. et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100, 197–207 (2000).

Article  CAS  PubMed  Google Scholar 

Abeynayake, N., Arthur, A. & Gronthos, S. Crosstalk between skeletal and neural tissues is critical for skeletal health. Bone 142, 115645 (2021).

Article  CAS  PubMed  Google Scholar 

Dimitri, P. & Rosen, C. The central nervous system and bone metabolism: an evolving story. Calcif. Tissue Int. 100, 476–485 (2017).

Article  CAS  PubMed  Google Scholar 

Ma, Q. A functional subdivision within the somatosensory system and its implications for pain research. Neuron 110, 749–769 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, K. et al. Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain. Cell Res. 31, 904–918 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, W. G. et al. The emerging science of interoception: sensing, integrating, interpreting, and regulating signals within the self. Trends Neurosci. 44, 3–16 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Quadt, L., Critchley, H. D. & Garfinkel, S. N. The neurobiology of