Skin permeability often increases in skin with impaired barrier function resulting in possibly a higher susceptibility to allergen minimal eliciting doses.

This overview summarizes data to be utilized in dermatotoxicology by comparing the minimal eliciting allergic contact dermatitis concentrations (MEC) between normal and damaged skin. This serves to demonstrate the higher propensity to allergic elicitation in damaged skin and expands the industrial knowledge of the impact of allergens on damaged skin.

The data helps to determine reasonable safe exposure concentrations in cosmetic and skin care products.