aRagon Institute of Mass General, MIT and Harvard, Cambridge, Massachusetts 02139

bDivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02115

Correspondence to Gaurav D. Gaiha, Ragon Institute of Mass General, Harvard and MIT, 400 Technology Square, Room 862, Cambridge, MA, USA 02139. Tel: + 857 268 7016; e-mail: [email protected]