Abdul Y, Abdelsaid M, Li W, Webb RC, Sullivan JC, Dong G, Ergul A (2019) Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4. Mol Neurobiol 56:1607–1617

Article  CAS  PubMed  Google Scholar 

Beisner J, Filipe Rosa L, Kaden-Volynets V, Stolzer I, Günther C, Bischoff SC (2021) Prebiotic Inulin and Sodium Butyrate Attenuate Obesity-Induced Intestinal Barrier Dysfunction by Induction of Antimicrobial Peptides. Front Immunol 12:678360

Article  CAS  PubMed  PubMed Central  Google Scholar 

Biessels GJ, Nobili F, Teunissen CE, Simó R, Scheltens P (2020) Understanding multifactorial brain changes in type 2 diabetes: a biomarker perspective. Lancet Neurol 19:699–710

Article  CAS  PubMed  Google Scholar 

Bluestone JA, Buckner JH, Herold KC (2021) Immunotherapy: Building a bridge to a cure for type 1 diabetes. Science 373:510–516

Article  CAS  PubMed  Google Scholar 

Cryan JF, O’Riordan KJ, Sandhu K, Peterson V, Dinan TG (2020) The gut microbiome in neurological disorders. Lancet Neurol 19:179–194

Article  CAS  PubMed  Google Scholar 

Duscha A et al (2020) Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism. Cell 180

Fang M, Ishigami J, Echouffo-Tcheugui JB, Lutsey PL, Pankow JS, Selvin E (2021) Diabetes and the risk of hospitalisation for infection: the Atherosclerosis Risk in Communities (ARIC) study. Diabetologia 64:2458–2465

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang W, Xue H, Chen X, Chen K, Ling W (2019) Supplementation with Sodium Butyrate Modulates the Composition of the Gut Microbiota and Ameliorates High-Fat Diet-Induced Obesity in Mice. J Nutr 149:747–754

Article  PubMed  Google Scholar 

Feigin VL, Stark BA, Johnson CO, Roth GA, Bisignano C, Abady GG, Abbasifard M, Abbasi-Kangevari M, Abd-Allah F, Abedi V, Abualhasan A (2021) Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol 20:795-820

Gale EA, Gillespie KM (2001) Diabetes and gender. Diabetologia 44

Garofalo S, Cocozza G, Porzia A, Inghilleri M, Raspa M, Scavizzi F, Aronica E, Bernardini G, Peng L, Ransohoff RM, Santoni A, Limatola C (2020) Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis. Nat Commun 11:1773

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haruwaka K, Ikegami A, Tachibana Y, Ohno N, Konishi H, Hashimoto A, Matsumoto M, Kato D, Ono R, Kiyama H, Moorhouse AJ, Nabekura J, Wake H (2019) Dual microglia effects on blood brain barrier permeability induced by systemic inflammation. Nat Commun 10:5816

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hassaballa H, Gorelick PB, West CP, Hansen MD, Adams HP (2001) Ischemic stroke outcome: racial differences in the trial of danaparoid in acute stroke (TOAST). Neurology 57:691–697

Article  CAS  PubMed  Google Scholar 

Hong P, Gu R-N, Li F-X, Xiong X-X, Liang W-B, You Z-J, Zhang H-F (2019) NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes. J Neuroinflamm 16:121

Article  Google Scholar 

Hong P, Li F-X, Gu R-N, Fang Y-Y, Lai L-Y, Wang Y-W, Tao T, Xu S-Y, You Z-J, Zhang H-F (2018) Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice. Neural Plast 2018:9163521

Article  PubMed  PubMed Central  Google Scholar 

Ito M, Komai K, Mise-Omata S, Iizuka-Koga M, Noguchi Y, Kondo T, Sakai R, Matsuo K, Nakayama T, Yoshie O, Nakatsukasa H, Chikuma S, Shichita T, Yoshimura A (2019) Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery. Nature 565:246–250

Article  CAS  PubMed  Google Scholar 

James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, Abbastabar H, Abd-Allah F, Abdela J, Abdelalim A, Abdollahpour I (2018) Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392:1789-1858

Kalani A, Kamat PK, Tyagi N (2015) Diabetic Stroke Severity: Epigenetic Remodeling and Neuronal, Glial, and Vascular Dysfunction. Diabetes 64:4260–4271

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kleinschnitz C et al (2013) Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 121:679–691

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kullmann S, Kleinridders A, Small DM, Fritsche A, Häring H-U, Preissl H, Heni M (2020) Central nervous pathways of insulin action in the control of metabolism and food intake. Lancet Diabetes Endocrinol 8:524–534

Article  CAS  PubMed  Google Scholar 

Lawson JM, Tremble J, Dayan C, Beyan H, Leslie RDG, Peakman M, Tree TIM (2008) Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes. Clin Exp Immunol 154:353–359

Article  CAS  PubMed  PubMed Central  Google Scholar 

Levard D, Buendia I, Lanquetin A, Glavan M, Vivien D, Rubio M (2021) Filling the gaps on stroke research: Focus on inflammation and immunity. Brain Behav Immun 91:649–667

Article  CAS  PubMed  Google Scholar 

Li TT, Sun T, Wang YZ, Wan Q, Li WZ, Yang WC (2022a) Molecular hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis. Eur J Pharmacol 914:174664

Article  CAS  PubMed  Google Scholar 

Li TT, Wan Q, Zhang X, Xiao Y, Sun LY, Zhang YR, Liu XN, Yang WC (2022b) Stellate ganglion block reduces inflammation and improves neurological function in diabetic rats during ischemic stroke. Neural Regen Res 17:1991–1997

Article  PubMed  PubMed Central  Google Scholar 

Li TT, Yang WC, Wang YZ, Sun T, Cao HL, Chen JF, Li WZ (2020a) Effects of a high concentration of hydrogen on neurological function after traumatic brain injury in diabetic rats. Brain Res 1730:146651

Article  CAS  PubMed  Google Scholar 

Li Z, Li M, Shi SX, Yao N, Cheng X, Guo A, Zhu Z, Zhang X, Liu Q (2020b) Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage. J Exp Med 217

Lo JW et al (2020) Association of Prediabetes and Type 2 Diabetes With Cognitive Function After Stroke: A STROKOG Collaboration Study. Stroke 51:1640–1646

Article  PubMed  Google Scholar 

Maj T, Wang W, Crespo J, Zhang H, Wang W, Wei S, Zhao L, Vatan L, Shao I, Szeliga W, Lyssiotis C, Liu JR, Kryczek I, Zou W (2017) Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor. Nat Immunol 18:1332–1341

Article  CAS  PubMed  PubMed Central  Google Scholar 

McGinley AM, Sutton CE, Edwards SC, Leane CM, DeCourcey J, Teijeiro A, Hamilton JA, Boon L, Djouder N, Mills KHG (2020) Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells. Immunity 52

O’Donnell MJ et al (2016) Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. Lancet 388:761–775

Article  PubMed  Google Scholar 

Owen DL et al (2019) Thymic regulatory T cells arise via two distinct developmental programs. Nat Immunol 20:195–205

Article  CAS  PubMed  PubMed Central  Google Scholar 

Proto JD, Doran AC, Gusarova G, Yurdagul A, Sozen E, Subramanian M, Islam MN, Rymond CC, Du J, Hook J, Kuriakose G, Bhattacharya J, Tabas I (2018) Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Immunity 49

Rosso C, Blanc R, Ly J, Samson Y, Lehéricy S, Gory B, Marnat G, Mazighi M, Consoli A, Labreuche J, Saleme S, Costalat V, Bracard S, Desal H, Piotin M, Lapergue B (2019) Impact of infarct location on functional outcome following endovascular therapy for stroke. J Neurol Neurosurg Psychiatry 90:313–319

Article  PubMed  Google Scholar 

Schwarz A, Bruhs A, Schwarz T (2017) The Short-Chain Fatty Acid Sodium Butyrate Functions as a Regulator of the Skin Immune System. J Invest Dermatol 137:855–864

Article  CAS  PubMed  Google Scholar 

Sharma M, Schlegel MP, Afonso MS, Brown EJ, Rahman K, Weinstock A, Sansbury BE, Corr EM, van Solingen C, Koelwyn GJ, Shanley LC, Beckett L, Peled D, Lafaille JJ, Spite M, Pn Loke, Fisher EA, Moore KJ (2020) Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression. Circ Res 127:335–353

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi K, Tian D-C, Li Z-G, Ducruet AF, Lawton MT, Shi F-D (2019) Global brain inflammation in stroke. Lancet Neurol 18:1058–1066

Article  PubMed  Google Scholar 

Shi L, Sun Z, Su W, Xu F, Xie D, Zhang Q, Dai X, Iyer K, Hitchens TK, Foley LM, Li S, Stolz DB, Chen K, Ding Y, Thomson AW, Leak RK, Chen J, Hu X (2021) Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke. Immunity 54

Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-y M, Glickman JN, Garrett WS (2013) The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341:569–573

Article  CAS  PubMed  Google Scholar 

Song M, Martinowich K, Lee FS (2017) BDNF at the synapse: why location matters. Mol Psychiatry 22:1370–1375

Article  CAS  PubMed  PubMed Central  Google Scholar 

Srikanth V, Sinclair AJ, Hill-Briggs F, Moran C, Biessels GJ (2020) Type 2 diabetes and cognitive dysfunction-towards effective management of both comorbidities. Lancet Diabetes Endocrinol 8:535–545

Article  PubMed  Google Scholar 

Sun W, Sun J, Li M, Xu Q, Zhang X, Tang Z, Chen J, Zhen J, Sun Z (2020) The effects of dietary sodium butyrate supplementation on the growth performance, carcass traits and intestinal microbiota of growing-finishing pigs. J Appl Microbiol 128:1613–1623

Article  CAS  PubMed