Management of the N0 Neck in Oral Cancer

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∙∙D’Cruz AK, Vaish R, Kapre N, Dandekar M, Gupta S, Hawaldar R et al Elective versus Therapeutic Neck Dissection in Node-Negative Oral Cancer N Engl. J Med 2015:373:521–29. https://doi.org/10.1056/NEJMoa1506007. The first randomized prospective study with a large enough number of patients to clearly define the role of END in the N0 neck. Also provided evidence for the depth of invasion as a risk factor

∙∙Hutchinson IL, Ridout F, Cheung SMY, Shah N, Pardee P, Surwald C et al. Nationwide randomized trial evaluating elective neck dissection for early-stage oral cancer (SEND study) with meta-analysis and concurrent real-world cohort. Br J Cancer 2019:121(10):827–36. https://doi.org/10.1038/s41416-019-0587-2This study was confirmatory for reference #12 but also demonstrated that END was effective for T1 cancers.

Singh A, Subash A, Sinha P. Comment on “Nationwide randomized trial evaluating elective neck dissection for early-stage cancer (SEND study) with metanalysis and concurrent real-world cohort. Br J Cancer. 2020;123(7):1202–3. https://doi.org/10.1038/s41416-020-0982-8.

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∙Ibrahim SA, Ahmed ANA, Elsersy HA, Darahem IMH. Elective neck dissection in T1/T2 oral squamous cell carcinoma with N0 neck: essential or not? A systematic review and meta-analysis. Eur Arch Otolaryngol. 2020:277(6):1741–1752. https://doi.org/10.1007/s00405-020-05866-3 Systematic Review and metanalysis of all prospective randomized trials on END

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∙Cao Y, Wang T, Yu C, Guo X, Li C, Li L Elective neck dissection versus wait-and-watch policy for oral cavity squamous carcinoma in early stage: a systematic review and meta-analysis based on survival data. J Oral Maxillofac Surg. 2019:77(10):2154–67 doi https://doi.org/10.1016/j.joms.2019.03.015. Systematic Review and metanalysis of all prospective randomized trials on END confirming the evidence for the use of END

Wushou A, Yibulayin F, Sheng L, Luo Y, Wang Z-C. Elective neck dissection improves the survival of patients with T2N0M0 squamous cell carcinoma: a study of the SEER database. BMV Cancer. 2021;21(1):1309. https://doi.org/10.1186/s12885-021-09053-3.

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