Novel Insights from Clinical Practice

Figueroa-Ramos G.a· Gatica-Torres M.a,b· López-López K.E.a· Domínguez-Cherit J.a

Author affiliations

aDepartment of Dermatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
bTec Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Mexico City, Mexico

Log in to MyKarger to check if you already have access to this content.

Buy FullText & PDF Unlimited re-access via MyKarger Unrestricted printing, no saving restrictions for personal use read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Rent via DeepDyve Unlimited fulltext viewing of this article Organize, annotate and mark up articles Printing and downloading restrictions apply

Start free trial

Subscribe Access to all articles of the subscribed year(s) guaranteed for 5 years Unlimited re-access via Subscriber Login or MyKarger Unrestricted printing, no saving restrictions for personal use read more

Subcription rates

Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

Received: October 28, 2022
Accepted: February 13, 2023
Published online: April 26, 2023

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 0

ISSN: 2296-9195 (Print)
eISSN: 2296-9160 (Online)

For additional information: https://www.karger.com/SAD

Abstract

Introduction: Keratoacanthoma (KA) is a group of tumors of epidermal origin with controversial nature. Subungual keratoacanthoma (SUKA) is a rare and destructive variant with more aggressive behavior. SUKA appears as a rapidly growing, painful tumor beneath the nail plate that rapidly progresses to a mass that can measure up to 2 cm. The toe location is unusual. The diagnosis must be made based on the correlation of clinical, radiological, and histopathological findings. Case Presentation: We present two cases of patients diagnosed with SUKAs with different clinical presentations which ranged from very typical to uncommon one. Both cases were treated with simple excision without recurrences. Conclusion: SUKA is a rare subungual tumor. Nail bed location represents a more difficult diagnostic challenge. SUKA should be suspected in the context of persistent and progressive pain on a finger or toe, once more frequent painful tumors have been ruled out.

© 2023 S. Karger AG, Basel

References Takai T, Misago N, Murata Y. Natural course of keratoacanthoma and related lesions after partial biopsy: clinical analysis of 66 lesions. J Dermatol. 2015 Feb 10;42(4):353–62. Nirenberg A, Steinman H, Dixon A. Keratoacanthoma: update on the debate. Am J Dermatopathol. 2021;43(4):305–7. Baran R, Mikhail G, Costini B, Tosti A, Goettmann-Bonvallot S. Distal digital keratoacanthoma: two cases with a review of the literature. Dermatol Surg. 2001;27(6):575–9. González-Rodríguez AJ, Gutiérrez-Paredes EM, Montesinos-Villaescusa E, Burgues Gasion O, Jorda-Cuevas E. Burgués gasión O, jordá-cuevas E. Subungual keratoacanthoma: the importance of distinguishing it from subungual squamous cell carcinoma. Actas Dermo-Sifiliograficas. 2012 Jul;103(6):549–51. Honma M, Kato N, Hashimoto M, Takahashi H, Ishida-Yamamoto A, Iizuka H. Subungual keratoacanthoma: analysis of cell proliferation and copy number variation of oncogenes compared with periungual squamous cell carcinoma. Clin Exp Dermatol. 2011;36(1):57–62. Richert B, Lecerf P, Caucanas M, André J. Nail tumors. Clin Dermatol. 2013 Sep;31(5):602–17. Miroux Catarino A, Catorze MG, Viana I. Subungual keratoacanthoma: a rare variant of keratoacanthoma. J Portuguese Soc Dermatol Venereol. 2018 Dec 27;76(4):425–8. Minotto R, Corte LD, Boff AL. Silva MVS da, Morais MR de. Queratoacantoma subungueal: relato de caso. Surg Cosmetic Dermat. 2014;6(4):377–9. Available from: http://www.surgicalcosmetic.org.br/details/366/en-US/queratoacantoma-subungueal–relato-de-caso. Baek HJ, Lee SJ, Cho KH, Choo HJ, Lee SM, Lee YH, et al. Subungual tumors: clinicopathologic correlation with US and MR imaging findings. RadioGraphics. 2010 Oct;30(6):1621–36. Choi JH, Shin DH, Shin DS, Cho KH. Subungual keratoacanthoma: ultrasound and magnetic resonance imaging findings. Skeletal Radiol. 2007 Mar 23;36(8):769–72. André J, Richert B. Le kératoacanthome sous-unguéal. Ann de Dermatologie de Venereologie. 2012 Jan;139(1):68–72. Göktay F, Kaynak E, Güneş P, Yaşar Ş, Kucukodacı Z, Aytekin S. Relationship between human papilloma virus and subungual keratoacanthoma: two case reports and the outcomes of surgical treatment. Skin Appendage Disord. 2016;2(3–4):92–6. Connolly M, Narayan S, Oxley J, de Berker DAR. Immunohistochemical staining for the differentiation of subungual keratoacanthoma from subungual squamous cell carcinoma. Clin Exp Dermatol. 2008 Sep;33(5):625–8. Simmons BJ, Baker JA, Zaiac M, Cho-Vega JH, Tosti A. Subungual keratoacanthoma in a patient with yellow nail syndrome. Dermatol Surg. 2016 Jul;42(7):900–2. Sinha A, Marsh R, Langtry J. Spontaneous regression of subungual keratoacanthoma with reossification of underlying distal lytic phalynx. Clin Exp Dermatol. 2005;30(1):20–2. Miguel-Gomez L, Turrion-Merino L, Reguero-Calleja ME, Munoz-Zato E. Subungual keratoacanthoma. Indian J Dermatol. 2015;60(6):623–4. Perelló-Alzamora MR, González-de Arriba M, Fernández-López E. Painful, rapidly growing tumor in the subungual area of the first digit of the right hand. Actas Dermosifiliogr. 2013 May;104(4):347–8. Pellegrini VDJr, Tompkins A. Management of subungual keratoacanthoma. J Hand Surg Am. 1986;11(5):718–24. Cecchi R, Troiano M, Buralli L, Innocenti S. Recurrent distal digital keratoacanthoma of the periungual region treated with mohs micrographic surgery. Australas J Dermatol. 2012 Feb;53(1):e5–7. Article / Publication Details

Received: October 28, 2022
Accepted: February 13, 2023
Published online: April 26, 2023

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 0

ISSN: 2296-9195 (Print)
eISSN: 2296-9160 (Online)

For additional information: https://www.karger.com/SAD

Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.