Fetal Diagnosis and Therapy

Meislin R.a· Stone J.a· Lookstein R.b· Stoffels G.c· Rebarber A.a· Fox N.S.a· Vieira L.a

Author affiliations

aDepartment of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA
bDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
cDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA

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Article / Publication Details

Received: October 28, 2022
Accepted: March 07, 2023
Published online: March 16, 2023

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 4

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: https://www.karger.com/FDT

Abstract

Introduction: Higher order fetal gestation is associated with adverse pregnancy outcomes, and monochorionic (MC) pregnancies have unique complications. Multifetal pregnancy reduction (MPR) by radiofrequency ablation (RFA) may be used to optimize the outcomes of a single fetus. The purpose of this study was to determine whether pregnancy outcomes differ for elective reduction compared to reduction for medically complicated MC multifetal pregnancies. Methods: This was a retrospective cohort of patients with MC twins and higher order multiples who underwent MPR via RFA at a single institution between 2008 and 2021. Patients undergoing elective reduction were compared to patients undergoing reduction due to a complication of MC pregnancy. Pregnancy outcomes were evaluated. Results: Forty-eight patients who underwent RFA reduction between 2008 and 2021 were included in the analysis. Sixteen patients (33.3%) underwent elective RFA for MPR, and 32 (66.7%) underwent an RFA procedure for a complicated pregnancy. All pregnancies with RFA performed for elective indication had a continuing pregnancy (live birth rate 100%). There were no reported pregnancy losses within 4 weeks of the procedure when performed for a solely elective indication (n = 0) compared to 6.3% of complicated multifetal pregnancy (n = 2; 6.3%) (p = 0.001). Conclusion: In this retrospective cohort study, elective reduction of MC twins using RFA was associated with no cases of fetal loss or PPROM within 4 weeks of the procedure and a 100% live birth rate.

© 2023 S. Karger AG, Basel

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Received: October 28, 2022
Accepted: March 07, 2023
Published online: March 16, 2023

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 4

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: https://www.karger.com/FDT

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