High Incidences of Acute and Chronic Graft-Versus-Host Disease after Hematopoietic Cell Transplants for Acute Myeloid Leukemia Using Thiotepa, Busulfan, and Fludarabine Pretransplant Conditioning

Letter to the Editor

Free Access

Halahleh K.A.a· Ma’koseh M.a· Sultan I.b· Rimawi D.H.c· Muradi E.d· Gale R.P.e

Author affiliations

aDepartment of Internal Medicine-Hematology Oncology and Bone Marrow Transplantation, King Hussein Cancer Center, Amman, Jordan
bDepartment of Pediatrics, Hematology and medical Oncology, King Hussein Cancer Center, Amman, Jordan
cBiostatistics Unit, Research Office, King Hussein Cancer Center, Amman, Jordan
dDepartment of Internal Medicine, University of Tripoli, Tripoli, Libya
eDepartment of Immunology and Inflammation, Centre for Haematology Research, Imperial College London, London, UK

Corresponding Author

Khalid Abdelrahman Halahleh, abuannas@hotmail.com


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Abstract of Letter to the Editor References Ganapule A, Nemani S, Korula A, Lakshmi KM, Abraham A, Srivastava A, et al. Allogeneic stem cell transplant for acute myeloid leukemia: evolution of an effective strategy in India. J Glob Oncol 2017; 3(6):773–81. Giralt S. Busulfan based conditioning regimens: not all partners are equal. Lancet Oncol. 2015 16(15):1448–9. Bacigalupo A, Dominietto A, Ghiso A, Di Grazia C, Lamparelli T, Gualandi F, et al. Unmanipulated haploidentical bone marrow transplantation and post-transplant cyclophosphamide for hematologic malignanices following a myeloablative conditioning: an update. Bone Marrow Transpl. 2015; 50(Suppl 2):S37–9. Sora F, Grazia CD, Chiusolo P, Raiola AM, Bregante S, Mordini N, et al. Allogeneic hHemopoietic stem cell transplants in patients with acute myeloid leukemia (AML) prepared with busulfan and fludarabine (BUFLU) or thiotepa, busulfan and fludarabine (TBF): a retrospective study. Biol Blood Marrow Transplant. 2020;26:698–703. Saraceni F, Beohou E, Labopin M, Arcese W, Bonifazi F, Stepensky P, et al. Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT). Thiotepa, busulfan and fludarabine compared to busulfan and cyclophosphamide as conditioning regimen for allogeneic stem cell transplant from matched siblings and unrelated donors for acute myeloid leukemia. Am J Hematol. 2018;93(10):1211–9. Bacigalupo A, Maria Raiola A, Dominietto A, Di Grazia C, Gualandi F, Lint MTV, et al. Graft versus host disease in unmanipulated haploidentical marrow transplantation with a modified post-transplant cyclophosphamide (PT-CY) regimen: an update on 425 patients. Bone Marrow Transpl. 2019;54(Suppl 2):708–12. Przepiorka D, Weisdorf D, Martin P, Klingemann HG, Beatty P, Hows J, et al. 1994 consensus conference on acute GVHD grading. Bone Marrow Transpl. 1995;15(6):825–8. Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, et al. National institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 diagnosis and staging working Group report. Biol Blood Marrow Transpl. 2015; 21(3):389–401.e1. Heuser M, Freeman SD, Ossenkoppele GJ, Buccisano F, Hourigan CS, Ngai LL, et al. 2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party. Blood. 2021;138(26):2753–67. Antin JH, Childs R, Filipovich AH, Giralt S, Mackinnon S, Spitzer T, et al. Establishment of complete and mixed donor chimerism after allogeneic lymphohematopoietic transplantation: recommendations from a workshop at the 2001 Tandem Meetings of the International Bone Marrow transplant Registry and the American society of blood and marrow transplantation. Biol Blood Marrow Transpl. 2001;7:473–85. Article / Publication Details

Received: June 02, 2022
Accepted: November 05, 2022
Published online: November 29, 2022

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

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