Sridhar, M. S. Anatomy of cornea and ocular surface. Indian J. Ophthalmol. 66, 190–194 (2018).
PubMed PubMed Central Article Google Scholar
Xiao, Y. et al. Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int. Immunol. 30, 457–470 (2018).
CAS PubMed PubMed Central Article Google Scholar
Contreras-Ruiz, L., Ghosh-Mitra, A., Shatos, M. A., Dartt, D. A. & Masli, S. Modulation of conjunctival goblet cell function by inflammatory cytokines. Mediators Inflamm. 2013, 636812 (2013).
CAS PubMed PubMed Central Article Google Scholar
Payne, A. P. The harderian gland: a tercentennial review. J. Anat. 185, 1–49 (1994).
PubMed PubMed Central Google Scholar
Knop, E. & Knop, N. Lacrimal drainage-associated lymphoid tissue (LDALT): a part of the human mucosal immune system. Invest Ophthalmol. Vis. Sci. 42, 566–574 (2001).
Knop, N. & Knop, E. Conjunctiva-associated lymphoid tissue in the human eye. Investig. Ophthalmol. Vis. Sci. 41, 1270–1279 (2000).
Chodosh, J., Nordquist, R. E. & Kennedy, R. C. Comparative anatomy of mammalian conjunctival lymphoid tissue: a putative mucosal immune site. Dev. Comp. Immunol. 22, 621–630 (1998).
CAS PubMed Article Google Scholar
Knop, E. & Knop, N. The role of eye-associated lymphoid tissue in corneal immune protection. J. Anat. 206, 271–285 (2005).
PubMed PubMed Central Article Google Scholar
Knop, E., Knop, N. & Claus, P. Local production of secretory IgA in the eye-associated lymphoid tissue (EALT) of the normal human ocular surface. Investig. Ophthalmol. Vis. Sci. 49, 2322–2329 (2008).
Schuh, J. C. L. Mucosa-Associated Lymphoid Tissue and Tertiary Lymphoid Structures of the Eye and Ear in Laboratory Animals. Toxicol. Pathol. 49, 472–482 (2021).
Allansmith, M. R. et al. The immune response of the lacrimal gland to antigenic exposure. Curr. Eye Res. 6, 921–927 (1987).
CAS PubMed Article Google Scholar
Gudmundsson, O. G., Benediktsson, H. & Olafsdottir, K. T-lymphocyte subsets in the human lacrimal gland. Acta Ophthalmologica 66, 19–23 (1988).
CAS PubMed Article Google Scholar
Gudmundsson, O. G. et al. T cell populations in the lacrimal gland during aging. Acta Ophthalmologica 66, 490–497 (1988).
CAS PubMed Article Google Scholar
Nasu, M., Matsubara, O. & Yamamoto, H. Post-mortem prevalence of lymphocytic infiltration of the lacrymal gland: a comparative study in autoimmune and non-autoimmune diseases. J. Pathol. 143, 11–15 (1984).
CAS PubMed Article Google Scholar
Damato, B. E., Allan, D., Murray, S. B. & Lee, W. R. Senile atrophy of the human lacrimal gland: the contribution of chronic inflammatory disease. Br. J. Ophthalmol. 68, 674–680 (1984).
CAS PubMed PubMed Central Article Google Scholar
Obata, H. Anatomy and histopathology of the human lacrimal gland. Cornea 25, S82–S89 (2006).
Obata, H., Yamamoto, S., Horiuchi, H. & Machinami, R. Histopathologic study of human lacrimal gland. Stat. Anal. Spec. Ref. aging Ophthalmol. 102, 678–686 (1995).
Trujillo-Vargas, C. M. et al. Immune phenotype of the CD4 + T cells in the aged lymphoid organs and lacrimal glands. GeroScience, https://doi.org/10.1007/s11357-022-00529-z (2022).
Steven, P. et al. Experimental induction and three-dimensional two-photon imaging of conjunctiva-associated lymphoid tissue. Investig. Ophthalmol. Vis. Sci. 49, 1512–1517 (2008).
Siebelmann, S. et al. Development, alteration and real time dynamics of conjunctiva-associated lymphoid tissue. PloS One 8, e82355–e82355 (2013).
PubMed PubMed Central Article CAS Google Scholar
Steven, P. & Gebert, A. Conjunctiva-associated lymphoid tissue - current knowledge, animal models and experimental prospects. Ophthalmic Res. 42, 2–8 (2009).
Steven, P. et al. Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy. Int. J. Mol. Sci. 21, https://doi.org/10.3390/ijms21207514 (2020).
Hingorani, M., Metz, D. & Lightman, S. L. Characterisation of the normal conjunctival leukocyte population. Exp. Eye Res. 64, 905–912 (1997).
CAS PubMed Article Google Scholar
Hingorani, M., Calder, V. L., Buckley, R. J. & Lightman, S. L. The role of conjunctival epithelial cells in chronic ocular allergic disease. Exp. Eye Res. 67, 491–500 (1998).
CAS PubMed Article Google Scholar
Dua, H. S., Gomes, J. A., Donoso, L. A. & Laibson, P. R. The ocular surface as part of the mucosal immune system: conjunctival mucosa-specific lymphocytes in ocular surface pathology. Eye 9, 261–267 (1995).
Coursey, T. G. et al. Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells. Mucosal Immunol. 10, 743–756 (2017).
CAS PubMed Article Google Scholar
O’Brien, R. L. et al. αβ TCR+ T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking γδ T cells. Investig. Ophthalmol. Vis. Sci. 53, 301–308 (2012).
O’Brien, R. L. et al. Protective role of gammadelta T cells in spontaneous ocular inflammation. Investig. Ophthalmol. Vis. Sci. 50, 3266–3274 (2009).
Zhang, X. et al. NK cells promote Th-17 mediated corneal barrier disruption in dry eye. PLoS. One 7, e36822 (2012).
CAS PubMed PubMed Central Article Google Scholar
Zhang, X. et al. CD8( + ) cells regulate the T helper-17 response in an experimental murine model of Sjogren syndrome. Mucosal. Immunol. 7, 417–427 (2014).
CAS PubMed Article Google Scholar
Khandelwal, P. et al. Ocular mucosal CD11b + and CD103 + mouse dendritic cells under normal conditions and in allergic immune responses. PloS One 8, e64193 (2013).
CAS PubMed PubMed Central Article Google Scholar
Liu, Q., Smith, C. W., Zhang, W., Burns, A. R. & Li, Z. NK cells modulate the inflammatory response to corneal epithelial abrasion and thereby support wound healing. Am. J. Pathol. 181, 452–462 (2012).
CAS PubMed PubMed Central Article Google Scholar
Bialasiewicz, A. A., Schaudig, U., Ma, J. X., Vieth, S. & Richard, G. Alpha/beta- and gamma/delta-T-cell-receptor-positive lymphocytes in healthy and inflamed human conjunctiva. Graefes Arch. Clin. Exp. Ophthalmol. 234, 467–471 (1996).
CAS PubMed Article Google Scholar
Arnous, R. et al. Tissue resident memory T cells inhabit the deep human conjunctiva. Sci. Rep. 12, 6077 (2022).
CAS PubMed PubMed Central Article Google Scholar
Alam, J. et al. Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes. Mucosal Immunol. https://doi.org/10.1038/s41385-022-00507-w (2022).
Waddell, A., Vallance, J. E., Hummel, A., Alenghat, T. & Rosen, M. J. IL-33 Induces Murine Intestinal Goblet Cell Differentiation Indirectly via Innate Lymphoid Cell IL-13 Secretion. J. Immunol. 202, 598–607 (2019).
CAS PubMed Article Google Scholar
Li, Z., Burns, A. R., Rumbaut, R. E. & Smith, C. W. gamma delta T cells are necessary for platelet and neutrophil accumulation in limbal vessels and efficient epithelial repair after corneal abrasion. Am. J. Pathol. 171, 838–845 (2007).
CAS PubMed PubMed Central Article Google Scholar
St Leger, A. J. et al. An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal gammadelta T Cells. Immunity 47, 148–158.e145 (2017).
PubMed Central Article CAS Google Scholar
Alam, J. et al. IL-17 Producing Lymphocytes Cause Dry Eye and Corneal Disease With Aging in RXRα Mutant Mouse. Front Med. 9, 849990 (2022).
Shen, L., Barabino, S., Taylor, A. W. & Dana, M. R. Effect of the ocular microenvironment in regulating corneal dendritic cell maturation. Arch. Ophthalmol. 125, 908–915 (2007).
CAS PubMed PubMed Central Article Google Scholar
Ahadome, S. D. et al. Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy. JCI insight 1, https://doi.org/10.1172/jci.insight.87012 (2016).
Saban, D. R. et al. Deletion of Thrombospondin (TSP)-1 in Dendritic Cells (DC) of the Conjunctiva Exacerbates Allergic Conjunctivitis (AC). ARVO Meeting Abstracts 53, 1241 (2012).
Hamrah, P., Huq, S. O., Liu, Y., Zhang, Q. & Dana, M. R. Corneal immunity is mediated by heterogeneous population of antigen-presenting cells. J. Leukoc. Biol. 74, 172–178 (2003).
CAS PubMed Article Google Scholar
Jamali, A. et al. Characterization of Resident Corneal Plasmacytoid Dendritic Cells and Their Pivotal Role in Herpes Simplex Keratitis. Cell Rep. 32, 108099 (2020).
CAS PubMed PubMed Central Article Google Scholar
Jamali, A. et al. Plasmacytoid dendritic cell
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