Mammillary bodies act as a relay between hippocampus and upstream structures and have an independent role in memory and contribute particularly to episodic memory.[1] Their absence is extremely rare and has previously been described in very few cases.[1] [2] We report a case with magnetic resonance imaging (MRI) findings of mammillary bodies' absence in a child who underwent imaging for evaluation of seizures.

A 6-year-old male child of healthy nonconguineous parents presented with recurrent episodes of unprovoked falls for 1 month. There was no history of maternal drug intake, irradiation/abnormal event during pregnancy. Birth history was normal with full-term normal vaginal delivery without any history of perinatal insult/birth asphyxia. There was no history of any poor scholastic performance. Routine blood investigations and cerebrospinal fluid (CSF) analysis did not reveal any abnormalities. Interictal electroencephalogram (EEG) revealed periodically generalized epileptiform activity.

MRI brain revealed complete bilateral absence of mammillary bodies on three-dimensional (3D) T1 images ([Fig. 1]). Bilateral malrotated vertically oriented hippocampi were noted. There was absence of anterior pillars of fornix.

Complete absence (rather than atrophy) of mammillary bodies is extremely rare. Clinically these patients have developmental amnesia characterized by episodic memory loss.[3] To the best of our knowledge, only two cases have been described till date with complete absence of mammillary bodies.[1] [2] These cases include a patient having developmental amnesia who also had abnormally oriented hippocampi and absence of anterior pillars of fornix.[1] Another described case of absent mammillary bodies was associated with the Ohtahara Syndrome (early infantile epileptic encephalopathy with suppression burst) with presence of abnormal orientation of the hippocampi (also noted in our patient) and olivary-dentate dysplasia.[2] Both these cases had history of perinatal insult, whereas our patient did not have history of perinatal insult.

MRI findings in our patient completely resemble the case described by Rosenbaum et al who postulated that absence of mammillary body may be a congenital/prenatal developmental abnormality rather than due to perinatal insult.[1] The fact that our patient did not have any history of perinatal insult further supports this hypothesis. Additional malformations like vertically oriented hippocampi and absence of pillars of fornix also point toward a developmental malformation.

Other causes of mammillary body atrophy include perinatal insult, thiamine deficiency, and iatrogenic causes (such as after severing of fornix during surgery).[3] [4] [5] [6] However, these cases do not have associated symmetric hippocampal and forniceal abnormalities (as noted in our case).

Due to its rarity, little is known about direct behavioral consequences of mammillary bodies' absence. Further detailed neuropsychological evaluation of these patients may provide an insight to the complex memory pathways. Our case adds to the extremely limited literature of congenital absence of mammillary body with hippocampal malformation and forniceal anterior pillar absence. While most cases of mammillary bodies absence are due to acquired causes, however, our case supports the hypothesis that absence of mammillary bodies may also be due to congenital/prenatal abnormality, at least in some cases.

Article published online:
07 August 2022

© 2022. Association for Helping Neurosurgical Sick People. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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