Rossberg, M., Lendle, W., Pfleiderer, G., Tögel, A., Dreher, E.-L., Langer, E., Rassaerts, H., Kleinschmidt, P., Strack, H., Cook, R., Beck, U., Lipper, K.-A., Torkelson, T.R., Löser, E., Beutel, K.K. and Mann, T. (2006) Chlorinated Hydrocarbons in Ullmann’s Encyclopedia of Industrial Chemistry, Wiley Online Library, Germany, pp. 11–25.

Google Scholar 

Agency for Toxic Substances and Disease Registry (2019) Toxicological Profile for 1,2-Dichloropropane, Atlanta, GA, USA. Available from: http://www.atsdr.cdc.gov/ToxProfiles/tp.asp?id=831&tid=162/.

Timchalk, C., Dryzga, M.D., Smith, F.A. and Bartels, M.J. (1991) Disposition and metabolism of [14C] 1,2-dichloropropane following oral and inhalation exposure in Fischer 344 rats. Toxicology, 68, 291–306.

CAS  PubMed  Article  Google Scholar 

Fletcher, K.E., Löffler, F.E., Richnow, H.H. and Nijenhuis, I. (2009) Stable carbon isotope fractionation of 1,2-dichloropropane during dichloroelimination by Dehalococcoides populations. Environ. Sci. Technol., 43, 6915–6919.

CAS  PubMed  Article  Google Scholar 

Tesoriero, A.J., Löffler, F.E. and Liebscher, H. (2001) Fate and origin of 1,2-dichloropropane in an unconfined shallow aquifer. Environ. Sci. Technol., 35, 455–461.

CAS  PubMed  Article  Google Scholar 

Albrecht, W.N. and Chenchin, K. (1985) Dissipation of 1,2-dibromo-3-chloropropane (DBCP), cis-1,3-dichloropropene (1,3-DCP), and dichloropropenes from soil to atmosphere. Bull. Environ. Contam. Toxicol., 34, 824–831.

CAS  PubMed  Article  Google Scholar 

Loffler, F.E., Champine, J.E., Ritalahti, K.M., Sprague, S.J. and Tiedje, J.M. (1997) Complete reductive dechlorination of 1,2-dichloropropane by anaerobic bacteria. Appl. Environ. Microbiol., 63, 2870–2875.

CAS  PubMed  PubMed Central  Article  Google Scholar 

[No authors listed] (1999) 1,2-Dichloropropane. IARC Monogr. Eval. Carcinog. Risks Hum., 71 Pt 3, 1393–1400.

Toyoda, Y., Takada, T. and Suzuki, H. (2016) Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis. Sci. Rep., 6, 24586.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Imberti, R., Calabrese, S.R., Emilio, G., Marchi, L. and Giuffrida, L. (1987) Acute poisoning with solvents: chlorinated aliphatic hydrocarbons. Minerva Anestesiol., 53, 399–403.

CAS  PubMed  Google Scholar 

Lucantoni, C., Grottoli, S. and Gaetti, R. (1992) 1,2-Dichloropropane is a renal and liver toxicant. Letter. Toxicol. Appl. Pharmacol., 117, 133.

CAS  PubMed  Article  Google Scholar 

World Health Organization (1986) 1,2-Dichloropropane. IARC Monogr. Eval. Carcinog. Risk Chem. Hum., 41, 131–147.

Google Scholar 

Di Nucci, A., Imbriani, M., Ghittori, S., Gregotti, C., Baldi, C., Locatelli, C., Manzo, L. and Capodaglio, E. (1988) 1,2-Dichloropropane-induced liver toxicity: Clinical data and preliminary studies in rats in The Target Organ and the Toxic Process. Springer, pp. 370–374.

Larcan, A., Lambert, H., Laprevote, M.C. and Gustin, B. (1976) Acute poisoning induced by dichloropropane. Acta Pharmacol. Toxicol. (Copenh.), 41 Suppl 2, 330.

Google Scholar 

Pozzi, C., Marai, P., Ponti, R., Dell’Oro, C., Sala, C., Zedda, S. and Locatelli, F. (1985) Toxicity in man due to stain removers containing 1, 2-dichloropropane. Br. J. Ind. Med., 42, 770–772.

CAS  PubMed  PubMed Central  Google Scholar 

Umeda, Y., Matsumoto, M., Aiso, S., Nishizawa, T., Nagano, K., Arito, H. and Fukushima, S. (2010) Inhalation carcinogenicity and toxicity of 1,2-dichloropropane in rats. Inhal. Toxicol., 22, 1116–1126.

CAS  PubMed  Article  Google Scholar 

Matsumoto, M., Umeda, Y., Take, M., Nishizawa, T. and Fukushima, S. (2013) Subchronic toxicity and carcinogenicity studies of 1,2-dichloropropane inhalation to mice. Inhal. Toxicol., 25, 435–443.

CAS  PubMed  Article  Google Scholar 

Benbrahim-Tallaa, L., Lauby-Secretan, B., Loomis, D., Guyton, K.Z., Grosse, Y., El Ghissassi, F., Bouvard, V., Guha, N., Mattock, H. and Straif, K.; International Agency for Research on Cancer Monograph Working Group (2014) Carcinogenicity of perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone. Lancet Oncol., 15, 924–925.

PubMed  Article  Google Scholar 

Marcus, Y., Shefer, G. and Stern, N. (2013) Adipose tissue renin-angiotensin-aldosterone system (RAAS) and progression of insulin resistance. Mol. Cell. Endocrinol., 378, 1–14.

CAS  PubMed  Article  Google Scholar 

Yang, W., Yu, X., Zhang, Q., Lu, Q., Wang, J., Cui, W., Zheng, Y., Wang, X. and Luo, D. (2013) Attenuation of streptozotocin-induced diabetic retinopathy with low molecular weight fucoidan via inhibition of vascular endothelial growth factor. Exp. Eye Res., 115, 96–105.

CAS  PubMed  Article  Google Scholar 

Yang, Z., Wang, H., Jiang, Y. and Hartnett, M.E. (2014) VEGFA activates erythropoietin receptor and enhances VEGFR2-mediated pathological angiogenesis. Am. J. Pathol., 184, 1230–1239.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Barot, M., Gokulgandhi, M.R., Patel, S. and Mitra, A.K. (2013) Microvascular complications and diabetic retinopathy: recent advances and future implications. Future Med. Chem., 5, 301–314.

CAS  PubMed  Article  Google Scholar 

Senger, D.R., Galli, S.J., Dvorak, A.M., Perruzzi, C.A., Harvey, V.S. and Dvorak, H.F. (1983) Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science, 219, 983–985.

CAS  PubMed  Article  Google Scholar 

Shibuya, M. (2006) Vascular endothelial growth factor (VEGF)-Receptor2: its biological functions, major signaling pathway, and specific ligand VEGF-E. Endothelium, 13, 63–69.

CAS  PubMed  Article  Google Scholar 

Takekoshi, K., Isobe, K., Yashiro, T., Hara, H., Ishii, K., Kawakami, Y., Nakai, T. and Okuda, Y. (2004) Expression of vascular endothelial growth factor (VEGF) and its cognate receptors in human pheochromocytomas. Life Sci., 74, 863–871.

CAS  PubMed  Article  Google Scholar 

Smyth, H.F., Jr., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A. and Nycum, J.S. (1969) Range-finding toxicity data: List VII. Am. Ind. Hyg. Assoc. J., 30, 470–476.

CAS  PubMed  Article  Google Scholar 

Park, J., Lee, H., Tran, Q., Mun, K., Kim, D., Hong, Y., Kwon, S.H., Brazil, D., Park, J. and Kim, S.H. (2017) Recognition of transmembrane protein 39A as a tumor-specific marker in brain tumor. Toxicol. Res., 33, 63–69.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Baruffini, A., Cirla, A.M., Pisati, G., Ratti, R. and Zedda, S. (1989) Allergic contact dermatitis from 1,2-dichloropropane. Contact Derm., 20, 379–380.

CAS  Article  Google Scholar 

Hess, A., Bloch, W., Wittekindt, C., Siodladczek, J., Addicks, K. and Michel, O. (2000) Immunohistochemical detection of vascular endothelial growth factor (VEGF) and VEGF-receptors Flt-1 and KDR/Flk-1 in the vestibule of guinea pigs. Neurosci. Lett., 280, 147–150.

CAS  PubMed  Article  Google Scholar 

Ellis, L.M. and Hicklin, D.J. (2008) VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat. Rev. Cancer, 8, 579–591.

CAS  PubMed  Article  Google Scholar 

Hidalgo, M. and Rowinsky, E.K. (2000) The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene, 19, 6680–6686.

CAS  PubMed  Article  Google Scholar 

Neufeld, G., Cohen, T., Gengrinovitch, S. and Poltorak, Z. (1999) Vascular endothelial growth factor (VEGF) and its receptors. FASEB J., 13, 9–22.

CAS  PubMed  Article  Google Scholar 

Bruckner, J., MacKenzie, W.F., Ramanathan, R., Muralidhara, S., Kim, H.J. and Dallas, C.E. (1989) Oral toxicity of 1,2-dichloropropane: acute, short-term, and long-term studies in rats. Fundam. Appl. Toxicol., 12, 713–730.

CAS  PubMed  Article  Google Scholar 

Fiaccadori, E., Maggiore, U., Rotelli, C., Giacosa, R., Ardissino, D., De Palma, G., Bergamaschi, E. and Mutti, A. (2003) Acute renal and hepatic failure due to accidental percutaneous absorption of 1,2-dichlorpropane contained in a commercial paint fixative. Nephrol. Dial. Transplant., 18, 219–220.

CAS  PubMed  Article  Google Scholar 

Kumagai, S., Kurumatani, N., Arimoto, A. and Ichihara, G. (2013) Cholangiocarcinoma among offset colour proof-printing workers exposed to 1,2-dichloropropane and/or dichloromethane. Occup. Environ. Med., 70, 508–510.

CAS  PubMed  Article  Google Scholar 

Kubo, S., Nakanuma, Y., Takemura, S., Sakata, C., Urata, Y., Nozawa, A., Nishioka, T., Kinoshita, M., Hamano, G., Terajima, H., Tachiyama, G., Matsumura, Y., Yamada, T., Tanaka, H., Nakamori, S., Arimoto, A., Kawada, N., Fujikawa, M., Fujishima, H., Sugawara, Y., Tanaka, S., Toyokawa, H., Kuwae, Y., Ohsawa, M., Uehara, S., Sato, K.K., Hayashi, T. and Endo, G. (2014) Case series of 17 patients with cholangiocarcinoma among young adult workers of a printing company in Japan. J. Hepatobiliary Pancreat. Sci., 21, 479–488.

PubMed  Article  Google Scholar 

Eliceiri, B.P., Paul, R., Schwartzberg, P.L., Hood, J.D., Leng, J. and Cheresh, D.A. (1999) Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol. Cell, 4, 915–924.

CAS  PubMed  Article  Google Scholar 

Fadouloglou, V.E., Balomenou, S., Aivaliotis, M., Kotsifaki, D., Arnaouteli, S., Tomatsidou, A., Efstathiou, G., Kountourakis, N., Miliara, S., Griniezaki, M., Tsalafouta, A., Pergantis, S.A., Boneca, I.G., Glykos, N.M., Bouriotis, V. and Kokkinidis, M. (2017) Unusual α-carbon hydroxylation of proline promotes active-site maturation. J. Am. Chem. Soc., 139, 5330–5337.

CAS  PubMed  Article  Google Scholar 

Bae, C.J., Shim, S.B., Jee, S.W., Lee, S.H., Kim, M.R., Lee, J.W., Lee, C.K. and Hwang, D.Y. (2010) IL-6, VEGF, KC and RANTES are a major cause of a high irritant dermatitis to phthalic anhydride in C57BL/6 inbred mice. Allergol. Int., 59, 389–397.

CAS  PubMed  Article  Google Scholar 

Carmeliet, P. (2000) Mechanisms of angiogenesis and arteriogenesis. Nat. Med., 6, 389–395.

CAS  PubMed