Anticancer Section / Original Paper

Liu Y. · Wu Y. · Wu F. · Hu C.

Author affiliations

Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, China

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Article / Publication Details

First-Page Preview

Received: January 21, 2022
Accepted: June 14, 2022
Published online: June 28, 2022

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: https://www.karger.com/CHE

Abstract

There is no standard therapy for nonsmall-cell lung cancer harboring rare coexistent EGFR mutations. Here, we report a female patient who was diagnosed as lung adenocarcinoma with three mutations of G724S, E709K, and V689I in exon 18. The patient responded to, but also showed rapid development of resistance to multiple therapies, including a second-generation EGFR-TKI of afatinib, a platinum-based doublet chemotherapy, and a multiple target TKI of anlotinib. As such, she ended up with a short overall survival time. Further research is required to understand the resistance mechanism(s) of these complex gene mutations.

© 2022 S. Karger AG, Basel

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First-Page Preview

Received: January 21, 2022
Accepted: June 14, 2022
Published online: June 28, 2022

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: https://www.karger.com/CHE

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