Updates in the Pharmacologic Prophylaxis and Treatment of Invasive Candidiasis in the Pediatric and Neonatal Intensive Care Units

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Benjamin DK, Jr., Kaufman DA, Hope WW, Smith PB, Arrieta A, Manzoni P, et al. A phase 3 study of micafungin versus amphotericin B deoxycholate in infants with invasive candidiasis. Pediatr Infect Dis J. 2018;37(10):992–8. doi: https://doi.org/10.1097/INF.0000000000001996. This is an important recent comparative study, albeit small, potentially supporting micafungin use in neonates and infants for IC.

Kim J, Nakwa FL, Araujo Motta F, Liu H, Dorr MB, Anderson LJ, et al. A randomized, double-blind trial investigating the efficacy of caspofungin versus amphotericin B deoxycholate in the treatment of invasive candidiasis in neonates and infants younger than 3 months of age. J Antimicrob Chemother. 2020;75(1):215–20. doi: https://doi.org/10.1093/jac/dkz398. This is an important recent comparative study, albeit small, potentially supporting caspofungin use in neonates and infants for IC.

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