1. Kloppenburg, M, Berenbaum, F. Osteoarthritis year in review 2019: epidemiology and therapy. Osteoarthritis Cartilage 2020; 28: 242–248.
Google Scholar | Crossref | Medline2. Hunter, DJ, Bierma-Zeistra, S. Osteoarthritis. Lancet 2019; 393: 1745–1759.
Google Scholar | Crossref | Medline3. Schmidt, TW . Approach to osteoarthritis management for the primary care provider. Prim Care 2018; 45: 361–378.
Google Scholar | Crossref | Medline4. Nelson, AE . Osteoarthritis year in review 2017: clinical. Osteoarthritis Cartilage 2018; 26: 319–325.
Google Scholar | Crossref | Medline5. Deshpande, BR, Katz, JN, Solomon, DH, et al. Number of persons with symptomatic knee osteoarthritis in the US: impact of race and ethnicity, age, sex, and obesity. Arthritis Care Res 2016; 68: 1743–1750.
Google Scholar | Crossref | Medline | ISI6. Spitaels, D, Mamouris, P, Vaes, B, et al. Epidemiology of knee osteoarthritis in general practice: a registry-based study. BMJ Open 2020; 10: e031734.
Google Scholar | Crossref | Medline7. Neogi, T . The epidemiology and impact of pain in osteoarthritis. Osteoarthritis Cartilage 2013; 21: 1145–1153.
Google Scholar | Crossref | Medline | ISI8. Andrew, R, Derry, S, Taylor, RS, et al. The costs and consequences of adequately managed chronic non-cancer pain and chronic neuropathic pain. Pain Pract 2014; 14: 79–94.
Google Scholar | Crossref | Medline9. Hadi, MA, McHugh, GA. Impact of chronic pain on patients’ quality of life: a comparative mixed-methods study. J Patient Exp 2019; 6: 133–141.
Google Scholar | SAGE Journals | ISI10. Kowal, J, Wilson, KG, McWilliams, LA, et al. Self-perceived burden in chronic pain: relevance, prevalence, and predictors. Pain 2012; 153: 1735–1741.
Google Scholar | Crossref | Medline | ISI11. Conaghan, PG, Peloso, PM, Everett, SV, et al. Inadequate pain relief and large functional loss among patients with knee osteoarthritis: evidence from a prospective multinational longitudinal study of osteoarthritis real-world therapies. Rheumatology 2015; 54: 270–277.
Google Scholar | Crossref | Medline12. Johnson, MI, Jones, G, Paley, CA, et al. The clinical efficacy of transcutaneous electrical nerve stimulation (TENS) for acute and chronic pain: a protocol for a meta-analysis of randomised controlled trials (RCTs). BMJ Open 2019; 9: e029999.
Google Scholar | Crossref13. Kolasinski, SL, Neogi, T, Hochberg, MC, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Review Arthritis Care Res 2020; 72: 149–162.
Google Scholar | Crossref | Medline14. Bannuru, RR, Osani, MC, Vaysbrot, EE, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage 2019; 27: 1578–1589.
Google Scholar | Crossref | Medline15. Arden, NK, Perry, TA, Bannuru, RR, et al. Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines. Nat Rev Rheumatol 2021; 17: 59–66.
Google Scholar | Crossref | Medline16. Jordan, KM, Arden, N, Doherty, M, et al. EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a task force of the standing committee for international clinical studies including therapeutic trials (ESCISIT). Ann Rheum Dis 2003; 62: 1145–1155.
Google Scholar | Crossref | Medline | ISI17. Block, JA . Osteoarthritis: OA guidelines: improving care or merely codifying practice. Nat Rev Rheumatol 2014; 10: 324–326.
Google Scholar | Crossref | Medline18. Gibson, W, Wand, BM, Meads, C, et al. Transcutaneous electrical nerve stimulation (TENS) for chronic pain – an overview of Cochrane Reviews. Cochrane Database Syst Rev 2019; 2: CD011890.
Google Scholar | Medline19. Sluka, KA, Bjordal, JM, Marchand, S, et al. What makes transcutaneous electrical nerve stimulation work? Making sense of the mixed results in the clinical literature. Phys Ther 2013; 93: 1397–1402.
Google Scholar | Crossref | Medline20. Gibson, W, Wand, BMO, Connell, NE. Transcutaneous electrical nerve stimulation (TENS) for neuropathic pain in adults. Cochrane Database Syst Rev 2017; 9: CD011976.
Google Scholar | Medline21. Coutaux, A . Non-pharmacological treatments for pain relief: TENS and acupuncture. Joint Bone Spine 2017; 84: 657–661.
Google Scholar | Crossref | Medline22. Osiri, M, Welch, V, Brosseau, L, et al. Transcutaneous electrical nerve stimulation for the knee osteoarthritis. Cochrane Database Syst Rev 2000; 4: CD002823.
Google Scholar | Crossref23. Rutjes, AW, Nuesch, E, Sterchi, R, et al. Transcutaneous electrostimulation for osteoarthritis of the knee. Cochrane Database Syst Rev 2009; 4: CD002823.
Google Scholar24. Vance, CGT, Dailey, DL, Rakel, BA, et al. Using TENS for pain control. The state of the evidence. Pain Manag 2014; 4: 197–209.
Google Scholar | Crossref | Medline25. Mora, JC, Przkora, R, Cruz-Almeida, Y. Knee osteoarthritis: pathophysiology and current treatment modalities. J Pain Res 2018; 11: 2189–2196.
Google Scholar | Crossref | Medline26. Kellgren, JH, Lawrence, JS. Radiological assessment of osteo-arthritis. Ann Rheum Dis 1957; 16: 494–502.
Google Scholar | Crossref | Medline | ISI27. Carr, ECJ, Meredith, P, Chumbley, G, et al. Pain: a quality of care issue during patients’ admission to hospital. J Adv Nurs 2014; 70: 1391–1403.
Google Scholar | Crossref | Medline | ISI28. Van den Kerkhof, EG, Stitt, L, Clark, A, et al. Sensitivity of the DN4 in screening for neuropathic pain syndromes. Clin J Pain 2018; 34: 30–36.
Google Scholar | Crossref | Medline29. Soriot-Thomas, S, Abraham-Briffod, P, Le Bastard, F. Neurostimulation method for the treatment of moderate to severe chronic nociceptive pain in knee osteoarthritis. Patent Application Publication . Pub. No: US2020/01477378 A1. 2020, https://www.freepatentsonline.com/20200147378.pdf
Google Scholar30. Johnson, M . Transcutaneous electrical nerve stimulation (TENS). Research to support clinical practice. Oxford: Oxford University Press, 2014.
Google Scholar | Crossref31. Bellamy, N, Buchanan, WW, Goldsmith, CH, et al. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 1988; 15: 1833–1840.
Google Scholar | Medline | ISI32. EuroQol Group (1990). EuroQol – a new facility for the measurement of health-related quality of life. Health Policy 1990; 16: 199–208.
Google Scholar33. Guy, W . ECDEU assessment manual for psychopharmacology, Revised. US Department of Health, Education, and Welfare Publication (ADM) . Rockville, MD: National Institute of Mental Health, 1976, pp. 76–338.
Google Scholar34. Pham, T, van der Heijde, D, Altman, RD, et al. OMERACT-OARSI initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited. Osteoarthritis Cartilage 2004; 12: 389–399.
Google Scholar | Crossref | Medline | ISI35. Tubach, F, Ravaud, P, Martin-Mola, E, et al. Minimum clinically important improvement and patient acceptable symptom state in pain and function in rheumatoid arthritis, ankylosing spondylitis, chronic back pain, hand osteoarthritis, and hip and knee osteoarthritis: results from a prospective multinational study. Arthritis Care Res 2012; 64: 1699–1707.
Google Scholar | Crossref | Medline | ISI36. Moore, A, Derry, S, Eccleston, C, et al. Expect analgesic failure; pursue analgesic success. BMJ 2013; 346: f2690.
Google Scholar | Crossref | Medline37. Stauffer, ME, Taylor, SD, Watson, DJ, et al. Definition of nonresponse to analgesic treatment of arthritic pain: an analytical literature review of the smallest detectable difference, the minimal detectable change, and the minimal clinically important difference on the pain visual analog scale. Int J Inflam 2011; 2011: 231926.
Google Scholar | Crossref | Medline38. Tripepi, G, Chesnaye, NC, Dekker, FW, et al. Intention to treat and per protocol analysis in clinical trials. Nephrology 2020; 25: 513–517.
Google Scholar | Crossref | Medline39. European Medicines Agency. Committee for Medicinal Products for Human Use (CHMP) . Guideline on missing data in confirmatory clinical trials. 2010. EMA/CPMP/EWP/1776/99Rev.1, chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/viewer.html?pdfurl=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fdocuments%2Fscientific-guideline%2Fguideline-missing-data-confirmatory-clinical-trials_en.pdf&clen=147855&chunk=true
Google Scholar40. Fu, K, Robbins, SR, McDougall, JJ. Osteoarthritis: the genesis of pain. Rheumatology 2018; 57: 43–50.
Google Scholar | Crossref41. Lluch, E, Torres, R, Nijs, J, et al. Evidence for central sensitization in patients with osteoarthritis pain: a systematic literature review. Eur J Pain 2014; 18: 1367–1375.
Google Scholar | Crossref | Medline42. Salaffi, F, Stancati, A, Silvestri, CA, et al. Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale. Eur J Pain 2004; 8: 283–291.
Google Scholar | Crossref | Medline | ISI43. Olsen, MF, Bjerre, E, Hansen, MD, et al. Minimum clinically important differences in chronic pain vary considerably by baseline pain and methodological factors: systematic review of empirical studies. J Clin Epidemiol 2018; 101: 87–106.
Google Scholar | Crossref | Medline44. Dworkin, RH, Turk, DC, Wyrwich, KW, et al. Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations. J Pain 2008; 9: 105–121.
Google Scholar | Crossref | Medline | ISI45. Copsey, B, Thompson, JY, Vadher, K, et al. Problems persist in reporting of methods and results for the WOMAC measure in hip and knee osteoarthritis trials. Qual Life Res 2019; 28: 335–343.
Google Scholar | Crossref | Medline46. Sarzi-Puttini, P, Velluci, R, Zuccaro, SM, et al. The appropriate treatment of chronic pain. Clin Drug Invest 2012; 32: 21–33.
Google Scholar | Crossref | ISI47. Latourte, A, Kloppenburg, M, Richette, P. Emerging pharmaceutical therapies for osteoarthritis. Nat Rev Rheumatol 2020; 16: 673–688.
Google Scholar | Crossref | Medline48. Cepeda, MS, Camargo, F, Zea, C, et al. Tramadol for osteoarthritis: a systematic review and metaanalysis. Rheumatology 2007; 34: 543–555.
Google Scholar49. Avouac, J, Gossec, L, Dougados, M. Efficacy and safety of opioids for osteoarthritis: a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage 2007; 15: 957–965.
Google Scholar | Crossref | Medline | ISI50. da Costa, BR, Nüesch, E, Kasteler, R, et al. Oral or transdermal opioids for osteoarthritis of the knee or hip. Cochrane Database Syst Rev 2014; 17: CD003115.
Google Scholar51. Smith, SR, Deshpande, BR, Collins, JE, et al. Comparative pain reduction of oral non-steroidal anti-inflammatory drugs and opioids for knee osteoarthritis: systematic analytic review. Osteoarthritis Cartilage 2016; 24: 962–972.
Google Scholar | Crossref | Medline | ISI52. Lo-Ciganic, WH, Floden, L, Lee, JK, et al. Analgesic use and risk of recurrent falls in participants with or